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In this paper, we conduct theoretical analyses on inferring the structure of gene regulatory networks. Depending on the experimental method and data type, the inference problem is classified into 20 different scenarios. For each scenario,…

Molecular Networks · Quantitative Biology 2022-02-18 Yue Wang , Zikun Wang

A mathematical model is identifiable if its parameters can be recovered from data. Here, we focus on a particular class of model, linear compartmental models, which are used to represent the transfer of substances in a system. We analyze…

Dynamical Systems · Mathematics 2021-06-22 Patrick Chan , Katherine Johnston , Anne Shiu , Aleksandra Sobieska , Clare Spinner

We generalize well-known results on structural identifiability of vector autoregressive models (VAR) to the case where the innovation covariance matrix has reduced rank. Structural singular VAR models appear, for example, as solutions of…

Econometrics · Economics 2020-12-08 Bernd Funovits , Alexander Braumann

A decomposition of a chemical reaction network (CRN) is produced by partitioning its set of reactions. The partition induces networks, called subnetworks, that are "smaller" than the given CRN which, at this point, can be called parent…

Molecular Networks · Quantitative Biology 2021-09-15 Lauro L. Fontanil , Eduardo R. Mendoza

Subramanian defined the complexity class CC as the set of problems log-space reducible to the comparator circuit value problem. He proved that several other problems are complete for CC, including the stable marriage problem, and finding…

Computational Complexity · Computer Science 2011-10-06 Stephen A. Cook , Dai Tri Man Le , Yuli Ye

By taking into account the nonlinear effect of the cause, the inner noise effect, and the measurement distortion effect in the observed variables, the post-nonlinear (PNL) causal model has demonstrated its excellent performance in…

Machine Learning · Statistics 2012-05-14 Kun Zhang , Aapo Hyvarinen

How do LLMs learn in-context? Is it by pattern-matching recent tokens, or by inferring latent structure? We probe this question using a toy graph random-walk across two competing graph structures. This task's answer is, in principle,…

Artificial Intelligence · Computer Science 2026-05-12 Katharine Kowalyshyn , Timothy Duggan , Daniel Little , Michael C Hughes

The study of cells and their responses to genetic or chemical perturbations promises to accelerate the discovery of therapeutic targets. However, designing adequate and insightful models for such data is difficult because the response of a…

Machine Learning · Computer Science 2024-12-04 Haiyi Mao , Romain Lopez , Kai Liu , Jan-Christian Hütter , David Richmond , Panayiotis V. Benos , Lin Qiu

Structural identifiability concerns the question of which unknown parameters of a model can be recovered from (perfect) input-output data. If all of the parameters of a model can be recovered from data, the model is said to be identifiable.…

Systems and Control · Electrical Eng. & Systems 2025-06-11 Nicolette Meshkat , Alexey Ovchinnikov , Thomas Scanlon

We classify all fundamental integrable spin chains with two-dimensional local Hilbert space which have regular R-matrices of difference form. This means that the R-matrix underlying the integrable structures is of the form R(u,v)=R(u-v) and…

Mathematical Physics · Physics 2020-04-01 Marius de Leeuw , Anton Pribytok , Paul Ryan

A key step in mechanistic modelling of dynamical systems is to conduct a structural identifiability analysis. This entails deducing which parameter combinations can be estimated from a given set of observed outputs. The standard…

Optimization and Control · Mathematics 2026-03-30 Johannes G Borgqvist , Alexander P Browning , Fredrik Ohlsson , Ruth E Baker

Identifiability of parameters is a fundamental prerequisite for model identification. It concerns uniqueness of the model parameters determined from experimental or simulated observations. This dissertation specifically deals with…

Economics · Quantitative Finance 2016-02-04 Di Molfetta Giuseppe

Capsule Networks (CapsNets) is a machine learning architecture proposed to overcome some of the shortcomings of convolutional neural networks (CNNs). However, CapsNets have mainly outperformed CNNs in datasets where images are small and/or…

Computer Vision and Pattern Recognition · Computer Science 2021-09-07 Juan P. Vigueras-Guillén , Arijit Patra , Ola Engkvist , Frank Seeliger

We study identifiability of the parameters in autoregressions defined on a network. Most identification conditions that are available for these models either rely on the network being observed repeatedly, are only sufficient, or require…

Econometrics · Economics 2022-06-06 Federico Martellosio

In structured system theory, a pattern matrix is a matrix with entries either fixed to zero or free to take arbitrary numbers. The (generic) rank of a pattern matrix is the rank of almost all its realizations. The resilience of various…

Information Theory · Computer Science 2024-11-19 Yuan Zhang , Yuanqing Xia , Gang Wang

Data-driven analysis of complex networks has been in the focus of research for decades. An important area of research is to study how well real networks can be described with a small selection of metrics, furthermore how well network models…

Social and Information Networks · Computer Science 2022-04-28 Marcell Nagy , Roland Molontay

Identifiability concerns finding which unknown parameters of a model can be quantified from given input-output data. Many linear ODE models, used in systems biology and pharmacokinetics, are unidentifiable, which means that parameters can…

Algebraic Geometry · Mathematics 2013-12-12 Nicolette Meshkat , Seth Sullivant

A code is called $(n, k, r, t)$ information symbol locally repairable code \big($(n, k, r, t)_i$ LRC\big) if each information coordinate can be achieved by at least $t$ disjoint repair sets, containing at most $r$ other coordinates. This…

Information Theory · Computer Science 2022-08-25 Deep Mukhopadhyay , Sanjit Bhowmick , Kalyan Hansda , Satya Bagchi

A topic of great current interest is Causal Representation Learning (CRL), whose goal is to learn a causal model for hidden features in a data-driven manner. Unfortunately, CRL is severely ill-posed since it is a combination of the two…

Machine Learning · Statistics 2024-06-10 Hiroshi Morioka , Aapo Hyvärinen

Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

Quantitative Methods · Quantitative Biology 2018-12-12 Alejandro F. Villaverde