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The ability to perform ab initio molecular dynamics simulations using potential energies calculated on quantum computers would allow virtually exact dynamics for chemical and biochemical systems, with substantial impacts on the fields of…

We present an open-source library of natively differentiable physics and robotics environments, accompanied by gradient-based control methods and a benchmark-ing suite. The introduced environments allow auto-differentiation through the…

Machine learning has emerged as a powerful solution to the modern challenges in accelerator physics. However, the limited availability of beam time, the computational cost of simulations, and the high-dimensionality of optimisation problems…

Accelerator Physics · Physics 2024-05-30 Jan Kaiser , Chenran Xu , Annika Eichler , Andrea Santamaria Garcia

Developing physics-based models for molecular simulation requires fitting many unknown parameters to diverse experimental datasets. Traditionally, this process is piecemeal and difficult to reproduce, leading to a fragmented landscape of…

Biological Physics · Physics 2025-04-10 Ryan K. Krueger , Megan C. Engel , Ryan Hausen , Michael P. Brenner

Current physics models used to interpret experimental measurements of particle beams require either simplifying assumptions to be made in order to ensure analytical tractability, or black box optimization methods to perform model based…

Accelerator Physics · Physics 2022-11-17 Ryan Roussel , Auralee Edelen

Linear dissipative differential equation is a fundamental model for a large number of physical systems, such as quantum dynamics with non-Hermitian Hamiltonian, open quantum system dynamics, diffusion process and damped system. In this…

Quantum Physics · Physics 2025-08-22 Gengzhi Yang , Akwum Onwunta , Dong An

The rapid evolution of large language models (LLMs) is transforming artificial intelligence into autonomous research partners, yet a critical gap persists in complex scientific domains such as combustion modeling. Here, practical AI…

Machine Learning · Computer Science 2026-01-06 Ke Xiao , Haoze Zhang , Runze Mao , Han Li , Zhi X. Chen

There is high demand on fire simulations, in both scale and quantity. We present a multi-pronged approach to improving the time and energy required to meet these demands. We show the ability of a custom machine learning surrogate model to…

Machine Learning · Computer Science 2025-10-01 James Panayis , Matt Field , Vignesh Gopakumar , Andrew Lahiff , Kristian Zarebski , Aby Abraham , Jonathan L. Hodges

Simulation has become the evaluation method of choice for many areas of distributing computing research. However, most existing simulation packages have several limitations on the size and complexity of the system being modeled. Fine…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-07-01 Dobre Ciprian , Cristea Valentin , Iosif C. Legrand

Machine learning as a discipline has seen an incredible surge of interest in recent years due in large part to a perfect storm of new theory, superior tooling, renewed interest in its capabilities. We present in this paper a framework named…

Biological systems with intertwined feedback loops pose a challenge to mathematical modeling efforts. Moreover, rare events, such as mutation and extinction, complicate system dynamics. Stochastic simulation algorithms are useful in…

Quantitative Methods · Quantitative Biology 2018-12-10 Alfonso Landeros , Timothy Stutz , Kevin L. Keys , Alexander Alekseyenko , Janet S. Sinsheimer , Kenneth Lange , Mary Sehl

Simulating spatiotemporal turbulence with high fidelity remains a cornerstone challenge in computational fluid dynamics (CFD) due to its intricate multiscale nature and prohibitive computational demands. Traditional approaches typically…

Fluid Dynamics · Physics 2024-07-01 Xiantao Fan , Deepak Akhare , Jian-Xun Wang

Differentiable simulators are an emerging concept with applications in several fields, from reinforcement learning to optimal control. Their distinguishing feature is the ability to calculate analytic gradients with respect to the input…

Machine Learning · Computer Science 2021-11-10 Antonio Stanziola , Simon R. Arridge , Ben T. Cox , Bradley E. Treeby

Process-Based Modeling (PBM) and Machine Learning (ML) are often perceived as distinct paradigms in the geosciences. Here we present differentiable geoscientific modeling as a powerful pathway toward dissolving the perceived barrier between…

Ammonia is a promising zero-carbon fuel for industrial and transport applications, but its combustion is hindered by flame instabilities, incomplete oxidation, and the formation of nitrogen oxides. Accurate and detailed kinetic models are…

Simulating rare events, such as the transformation of a reactant into a product in a chemical reaction typically requires enhanced sampling techniques that rely on heuristically chosen collective variables (CVs). We propose using…

Simulation-based optimization using agent-based models is typically carried out under the assumption that the gradient describing the sensitivity of the simulation output to the input cannot be evaluated directly. To still apply…

Machine Learning · Computer Science 2021-03-24 Philipp Andelfinger

Probabilistic user modeling is essential for building machine learning systems in the ubiquitous cases with humans in the loop. However, modern advanced user models, often designed as cognitive behavior simulators, are incompatible with…

Machine Learning · Computer Science 2023-06-29 Alex Hämäläinen , Mustafa Mert Çelikok , Samuel Kaski

We present the preliminary high-level design and features of DynamicPPL.jl, a modular library providing a lightning-fast infrastructure for probabilistic programming. Besides a computational performance that is often close to or better than…

Machine Learning · Computer Science 2020-02-10 Mohamed Tarek , Kai Xu , Martin Trapp , Hong Ge , Zoubin Ghahramani

Integrating computational fluid dynamics (CFD) solvers into optimization and machine-learning frameworks is hampered by the rigidity of classic computational languages and the slow performance of more flexible high-level languages. In this…

Fluid Dynamics · Physics 2025-07-22 Gabriel D. Weymouth , Bernat Font
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