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The COVID-19 pandemic has presented unprecedented challenges worldwide, necessitating effective modelling approaches to understand and control its transmission dynamics. In this study, we propose a novel approach that integrates…

Populations and Evolution · Quantitative Biology 2025-01-14 Moein Khalighi , Leo Lahti , Faïçal Ndaïrou , Peter Rashkov , Delfim F. M. Torres

The COVID-19 Pandemic has left a devastating trail all over the world, in terms of loss of lives, economic decline, travel restrictions, trade deficit, and collapsing economy including real-estate, job loss, loss of health benefits, the…

Plasmode simulation has become an important tool for evaluating the operating characteristics of different statistical methods in complex settings, such as pharmacoepidemiological studies of treatment effectiveness using electronic health…

In this paper, we provide insights on how much testing and social distancing is required to control COVID-19. To this end, we develop a compartmental model that accounts for key aspects of the disease: 1) incubation time, 2) age-dependent…

Optimization and Control · Mathematics 2020-11-04 Sara Grundel , Stefan Heyder , Thomas Hotz , Tobias K. S. Ritschel , Philipp Sauerteig , Karl Worthmann

The corona virus disease 2019 (COVID-19) caused by the novel corona virus has an exponential rate of infection. COVID-19 is particularly notorious as the onset of symptoms in infected patients are usually delayed and there exists a large…

Methodology · Statistics 2020-04-16 Lakshmi N. Theagarajan

The recent coronavirus disease (COVID-19) outbreak has dramatically increased the public awareness and appreciation of the utility of dynamic models. At the same time, the dissemination of contradictory model predictions has highlighted…

Populations and Evolution · Quantitative Biology 2020-06-26 Gemma Massonis , Julio R. Banga , Alejandro F. Villaverde

Recent works have proposed optimal subsampling algorithms to improve computational efficiency in large datasets and to design validation studies in the presence of measurement error. Existing approaches generally fall into two categories:…

Methodology · Statistics 2025-12-25 Jasper B. Yang , Thomas Lumley , Bryan E. Shepherd , Pamela A. Shaw

Quantile is an important risk measure quantifying the stochastic system random behaviors. This paper studies a pooled quantile estimator, which is the sample quantile of detailed simulation outputs after directly pooling independent sample…

Methodology · Statistics 2019-10-15 Qiong Zhang , Bo Wang , Wei Xie

The current pandemic has introduced substantial uncertainty to traditional methods for demand planning. These uncertainties stem from the disease progression, government interventions, economy and consumer behavior. While most of the…

Artificial Intelligence · Computer Science 2021-05-04 Shaz Hoda , Amitoj Singh , Anand Rao , Remzi Ural , Nicholas Hodson

This document analyzes the role of data-driven methodologies in Covid-19 pandemic. We provide a SWOT analysis and a roadmap that goes from the access to data sources to the final decision-making step. We aim to review the available…

Populations and Evolution · Quantitative Biology 2020-06-11 Teodoro Alamo , D. G. Reina , Pablo Millán

Motivated by massive outbreaks of COVID-19 that occurred even in populations with high vaccine uptake, we propose a novel multi-population temporal network model for the spread of recurrent epidemic diseases. We study the effect of human…

Dynamical Systems · Mathematics 2022-09-19 Kathinka Frieswijk , Lorenzo Zino , Ming Cao

The COVID-19 pandemic has forced policy makers to decree urgent confinements to stop a rapid and massive contagion. However, after that stage, societies are being forced to find an equilibrium between the need to reduce contagion rates and…

Testing is a crucial control mechanism in the beginning phase of an epidemic when the vaccines are not yet available. It enables the public health authority to detect and isolate the infected cases from the population, thereby limiting the…

Clinical trials disruption has always represented a non negligible part of the ending of interventional studies. While the SARS-CoV-2 (COVID-19) pandemic has led to an impressive and unprecedented initiation of clinical research, it has…

A contact-tracing strategy has been deemed necessary to contain the spread of COVID-19 following the relaxation of lockdown measures. Using an agent-based model, we explore one of the technology-based strategies proposed, a contact-tracing…

Computers and Society · Computer Science 2020-12-18 Jonatan Almagor , Stefano Picascia

This work introduces a novel epidemiological model that simultaneously considers multiple viral strains, reinfections due to waning immunity response over time and an optimal control formulation. This enables us to derive optimal mitigation…

Systems and Control · Electrical Eng. & Systems 2021-09-10 Edilson F. Arruda , Dayse H. Pastore , Clauda M. Dias , Shyam S. Das

COVID-19 has caused tremendous strain on healthcare systems worldwide. At the same time, concern within the population over this strain and the chances of becoming infected has potentially reduced the likelihood of people seeking medical…

Physics and Society · Physics 2022-06-07 Elizabeth Hunter , Bryony L. McGarry , John D. Kelleher

Catastrophe risk has long been recognized to pose a serious threat to the insurance sector. Catastrophe risk pooling offers an effective way to diversify losses arising from catastrophic events. In this paper, we investigate a structure of…

Risk Management · Quantitative Finance 2026-04-09 Minh Chau Nguyen , Tony S. Wirjanto , Fan Yang

Residential colleges and universities face unique challenges in providing in-person instruction during the COVID-19 pandemic. Administrators are currently faced with decisions about whether to open during the pandemic and what modifications…

Populations and Evolution · Quantitative Biology 2020-12-22 Philip T. Gressman , Jennifer R. Peck

The onset of the COVID-19 pandemic drove a widespread, often uncoordinated effort by research groups to develop mathematical models of SARS-CoV-2 to study its spread and inform control efforts. The urgent demand for insight at the outset of…

Populations and Evolution · Quantitative Biology 2023-06-21 Alexander N. Pillai , Kok Ben Toh , Dianela Perdomo , Sanjana Bhargava , Arlin Stoltzfus , Ira M. Longini , Carl A. B. Pearson , Thomas J. Hladish