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Causal variable selection in time-varying treatment settings is challenging due to evolving confounding effects. Existing methods mainly focus on time-fixed exposures and are not directly applicable to time-varying scenarios. We propose a…

A fundamental requirement for intelligent systems is the ability to learn continuously under changing environments. However, models trained in this regime often suffer from catastrophic forgetting. Leveraging pre-trained models has recently…

Artificial Intelligence · Computer Science 2026-03-12 Tung Tran , Danilo Vasconcellos Vargas , Khoat Than

Cancer evolves continuously over time through a complex interplay of genetic, epigenetic, microenvironmental, and phenotypic changes. This dynamic behavior drives uncontrolled cell growth, metastasis, immune evasion, and therapy resistance,…

Quantitative Methods · Quantitative Biology 2025-07-08 Luoting Zhuang , Stephen H. Park , Steven J. Skates , Ashley E. Prosper , Denise R. Aberle , William Hsu

We propose a Bayesian latent variable model to estimate covariate-assisted dependence structures across multiple modalities of multivariate data that may be observed asynchronously. This setting commonly arises in longitudinal biomedical…

Methodology · Statistics 2026-05-27 Kun Qian , Hyung G. Park

This paper explores the integration of two AI subdisciplines employed in the development of artificial agents that exhibit intelligent behavior: Large Language Models (LLMs) and Cognitive Architectures (CAs). We present three integration…

Artificial Intelligence · Computer Science 2023-09-29 Oscar J. Romero , John Zimmerman , Aaron Steinfeld , Anthony Tomasic

In this work, we conduct a systematic analysis of Native Sparse Attention (NSA) and propose targeted improvements that enhance long-context modeling. A key insight is that alternating between local (sliding-window) and global (compression,…

Computation and Language · Computer Science 2025-11-04 Yuxuan Hu , Jianchao Tan , Jiaqi Zhang , Wen Zan , Pingwei Sun , Yifan Lu , Yerui Sun , Yuchen Xie , Xunliang Cai , Jing Zhang

Diverse analysis approaches have been proposed to distinguish data missing due to death from nonresponse, and to summarize trajectories of longitudinal data truncated by death. We demonstrate how these analysis approaches arise from…

Methodology · Statistics 2010-01-18 Brenda F. Kurland , Laura L. Johnson , Brian L. Egleston , Paula H. Diehr

Canonical Correlation Analysis (CCA) is a widely used statistical tool with both well established theory and favorable performance for a wide range of machine learning problems. However, computing CCA for huge datasets can be very slow…

Machine Learning · Statistics 2014-12-31 Yichao Lu , Dean P. Foster

Effectively modeling multimodal longitudinal data is a pressing need in various application areas, especially biomedicine. Despite this, few approaches exist in the literature for this problem, with most not adequately taking into account…

Imaging in clinical routine is subject to changing scanner protocols, hardware, or policies in a typically heterogeneous set of acquisition hardware. Accuracy and reliability of deep learning models suffer from those changes as data and…

Machine Learning · Computer Science 2021-06-08 Matthias Perkonigg , Johannes Hofmanninger , Georg Langs

The integration of different imaging modalities, such as structural, diffusion tensor, and functional magnetic resonance imaging, with deep learning models has yielded promising outcomes in discerning phenotypic characteristics and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Zhiyuan Li , Hailong Li , Anca L. Ralescu , Jonathan R. Dillman , Mekibib Altaye , Kim M. Cecil , Nehal A. Parikh , Lili He

Describing the dimension reduction (DR) techniques by means of probabilistic models has recently been given special attention. Probabilistic models, in addition to a better interpretability of the DR methods, provide a framework for further…

Computer Vision and Pattern Recognition · Computer Science 2020-05-12 Mehran Safayani , Saeid Momenzadeh

Multi-view alignment, achieving one-to-one correspondence of multi-view inputs, is critical in many real-world multi-view applications, especially for cross-view data analysis problems. Recently, an increasing number of works study this…

Machine Learning · Computer Science 2020-05-26 Yaxin Shi , Yuangang Pan , Donna Xu , Ivor W. Tsang

Class imbalance problems frequently occur in real-world tasks, and conventional deep learning algorithms are well known for performance degradation on imbalanced training datasets. To mitigate this problem, many approaches have aimed to…

Computer Vision and Pattern Recognition · Computer Science 2023-02-14 Sumyeong Ahn , Jongwoo Ko , Se-Young Yun

Latent diffusion models have emerged as powerful generative models in medical imaging, enabling the synthesis of high quality brain magnetic resonance imaging scans. In particular, predicting the evolution of a patients brain can aid in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Duy-Phuong Dao , Muhammad Taqiyuddin , Jahae Kim , Sang-Heon Lee , Hye-Won Jung , Jaehoo Choi , Hyung-Jeong Yang

Long-Context Question Answering (LCQA), a challenging task, aims to reason over long-context documents to yield accurate answers to questions. Existing long-context Large Language Models (LLMs) for LCQA often struggle with the "lost in the…

Computation and Language · Computer Science 2024-11-04 Qingfei Zhao , Ruobing Wang , Yukuo Cen , Daren Zha , Shicheng Tan , Yuxiao Dong , Jie Tang

Canonical correlation analysis (CCA) is a technique for measuring the association between two multivariate data matrices. A regularized modification of canonical correlation analysis (RCCA) which imposes an $\ell_2$ penalty on the CCA…

Methodology · Statistics 2021-07-30 Elena Tuzhilina , Leonardo Tozzi , Trevor Hastie

Large Language Models (LLMs) have demonstrated strong performance across a wide range of tasks, yet they still struggle with complex mathematical reasoning, a challenge fundamentally rooted in deep structural dependencies. To address this…

Artificial Intelligence · Computer Science 2025-12-01 Lei Zan , Keli Zhang , Ruichu Cai , Lujia Pan

Interpretability is a key issue when applying deep learning models to longitudinal brain MRIs. One way to address this issue is by visualizing the high-dimensional latent spaces generated by deep learning via self-organizing maps (SOM). SOM…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Jiahong Ouyang , Qingyu Zhao , Ehsan Adeli , Wei Peng , Greg Zaharchuk , Kilian M. Pohl

Longitudinal analysis has great potential to reveal developmental trajectories and monitor disease progression in medical imaging. This process relies on consistent and robust joint 4D segmentation. Traditional techniques are dependent on…

Machine Learning · Computer Science 2019-06-19 Malav Bateriwala , Pierrick Bourgeat