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This paper considers canonical correlation analysis for two longitudinal variables that are possibly sampled at different time resolutions with irregular grids. We modeled trajectories of the multivariate variables using random effects and…

Applications · Statistics 2023-02-03 Seonjoo Lee , Jongwoo Choi , Zhiqian Fang , F. DuBois Bowman

In recent years, longitudinal neuroimaging study has become increasingly popular in neuroscience research to investigate disease-related changes in brain functions. In current neuroscience literature, one of the most commonly used tools to…

Methodology · Statistics 2018-08-07 Yikai Wang , Ying Guo

Multimodal Learning Analytics (MMLA) leverages advanced sensing technologies and artificial intelligence to capture complex learning processes, but integrating diverse data sources into cohesive insights remains challenging. This study…

Machine Learning · Computer Science 2024-11-26 Lixiang Yan , Dragan Gašević , Linxuan Zhao , Vanessa Echeverria , Yueqiao Jin , Roberto Martinez-Maldonado

Dementia affects cognitive functions of adults, including memory, language, and behaviour. Standard diagnostic biomarkers such as MRI are costly, whilst neuropsychological tests suffer from sensitivity issues in detecting dementia onset.…

Computation and Language · Computer Science 2023-12-27 Dimitris Gkoumas , Bo Wang , Adam Tsakalidis , Maria Wolters , Arkaitz Zubiaga , Matthew Purver , Maria Liakata

Many longitudinal neuroimaging studies aim to improve the understanding of brain aging and diseases by studying the dynamic interactions between brain function and cognition. Doing so requires accurate encoding of their multidimensional…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Yixin Wang , Wei Peng , Yu Zhang , Ehsan Adeli , Qingyu Zhao , Kilian M. Pohl

Accurate identification of late-life depression (LLD) using structural brain MRI is essential for monitoring disease progression and facilitating timely intervention. However, existing learning-based approaches for LLD detection are often…

Computer Vision and Pattern Recognition · Computer Science 2025-07-31 Yuzhen Gao , Qianqian Wang , Yongheng Sun , Cui Wang , Yongquan Liang , Mingxia Liu

The human brains are organized into hierarchically modular networks facilitating efficient and stable information processing and supporting diverse cognitive processes during the course of development. While the remarkable reconfiguration…

Neurons and Cognition · Quantitative Biology 2020-09-16 Xuyun Wen , Liming Hsu , Weili Lin , Han Zhang , Dinggang Shen

Canonical Correlation Analysis, CCA, is a widely used multivariate method in omics research for integrating high dimensional datasets. CCA identifies hidden links by deriving linear projections of features maximally correlating datasets.…

Methodology · Statistics 2025-10-31 Nuria Senar , Aeilko H. Zwinderman , Michel H. Hof and

Many neurological diseases are characterized by gradual deterioration of brain structure and function. Large longitudinal MRI datasets have revealed such deterioration, in part, by applying machine and deep learning to predict diagnosis. A…

Image and Video Processing · Electrical Eng. & Systems 2021-05-27 Jiahong Ouyang , Qingyu Zhao , Edith V Sullivan , Adolf Pfefferbaum , Susan F. Tapert , Ehsan Adeli , Kilian M Pohl

Multimodal data are now prevailing in scientific research. A central question in multimodal integrative analysis is to understand how two data modalities associate and interact with each other given another modality or demographic…

Methodology · Statistics 2021-04-27 Lexin Li , Jing Zeng , Xin Zhang

Machine learning analysis of longitudinal neuroimaging data is typically based on supervised learning, which requires a large number of ground-truth labels to be informative. As ground-truth labels are often missing or expensive to obtain…

Machine Learning · Computer Science 2021-06-29 Qingyu Zhao , Zixuan Liu , Ehsan Adeli , Kilian M. Pohl

Reconstructing the cortex from longitudinal magnetic resonance imaging (MRI) is indispensable for analyzing morphological alterations in the human brain. Despite the recent advancement of cortical surface reconstruction with deep learning,…

Image and Video Processing · Electrical Eng. & Systems 2025-02-20 Fabian Bongratz , Jan Fecht , Anne-Marie Rickmann , Christian Wachinger

Deep learning algorithms for predicting neuroimaging data have shown considerable promise in various applications. Prior work has demonstrated that deep learning models that take advantage of the data's 3D structure can outperform standard…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Yuda Bi , Anees Abrol , Zening Fu , Jiayu Chen , Jingyu Liu , Vince Calhoun

Multimodal learning, which integrates data from diverse sensory modes, plays a pivotal role in artificial intelligence. However, existing multimodal learning methods often struggle with challenges where some modalities appear more dominant…

Machine Learning · Computer Science 2024-04-02 Xiaohui Zhang , Jaehong Yoon , Mohit Bansal , Huaxiu Yao

Long-term action quality assessment (AQA) focuses on evaluating the quality of human activities in videos lasting up to several minutes. This task plays an important role in the automated evaluation of artistic sports such as rhythmic…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Xin Wang , Peng-Jie Li , Yuan-Yuan Shen

In mental health research, it has proven difficult to find measures of brain function that provide reliable indicators of mental health and well-being, including susceptibility to mental health disorders. Recently, a family of data-driven…

Neurons and Cognition · Quantitative Biology 2022-01-27 Nikhil Goyal1 , Dustin Moraczewski , Peter A. Bandettini , Emily S. Finn , Adam G. Thomas

The main idea of canonical correlation analysis (CCA) is to map different views onto a common latent space with maximum correlation. We propose a deep interpretable variational canonical correlation analysis (DICCA) for multi-view learning.…

Machine Learning · Statistics 2022-03-03 Lin Qiu , Lynn Lin , Vernon M. Chinchilli

Longitudinal fetal brain atlas is a powerful tool for understanding and characterizing the complex process of fetus brain development. Existing fetus brain atlases are typically constructed by averaged brain images on discrete time points…

Image and Video Processing · Electrical Eng. & Systems 2022-09-15 Lixuan Chen , Jiangjie Wu , Qing Wu , Hongjiang Wei , Yuyao Zhang

Artificial neural networks (ANNs) exhibit a narrow scope of expertise on stationary independent data. However, the data in the real world is continuous and dynamic, and ANNs must adapt to novel scenarios while also retaining the learned…

Computer Vision and Pattern Recognition · Computer Science 2023-10-18 Shruthi Gowda , Bahram Zonooz , Elahe Arani

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Gregory Holste , Mingquan Lin , Ruiwen Zhou , Fei Wang , Lei Liu , Qi Yan , Sarah H. Van Tassel , Kyle Kovacs , Emily Y. Chew , Zhiyong Lu , Zhangyang Wang , Yifan Peng
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