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We propose a general method for constructing hypothesis tests and confidence sets that have finite sample guarantees without regularity conditions. We refer to such procedures as "universal." The method is very simple and is based on a…

Statistics Theory · Mathematics 2022-10-21 Larry Wasserman , Aaditya Ramdas , Sivaraman Balakrishnan

Indirect Inference (I-I) is a popular technique for estimating complex parametric models whose likelihood function is intractable, however, the statistical efficiency of I-I estimation is questionable. While the efficient method of moments,…

Econometrics · Economics 2020-06-19 Veronika Czellar , David T. Frazier , Eric Renault

Increasingly complex applications involve large datasets in combination with non-linear and high dimensional mathematical models. In this context, statistical inference is a challenging issue that calls for pragmatic approaches that take…

Data Analysis, Statistics and Probability · Physics 2013-01-31 Andreas Raue , Clemens Kreutz , Fabian Joachim Theis , Jens Timmer

Bayesian inference requires specification of a single, precise prior distribution, whereas frequentist inference only accommodates a vacuous prior. Since virtually every real-world application falls somewhere in between these two extremes,…

Methodology · Statistics 2023-09-26 Ryan Martin

Statistical models of natural stimuli provide an important tool for researchers in the fields of machine learning and computational neuroscience. A canonical way to quantitatively assess and compare the performance of statistical models is…

Machine Learning · Statistics 2012-09-17 Lucas Theis , Sebastian Gerwinn , Fabian Sinz , Matthias Bethge

The rapid proliferation of high-quality synthetic data -- generated by advanced AI models or collected as auxiliary data from related tasks -- presents both opportunities and challenges for statistical inference. This paper introduces a…

Methodology · Statistics 2026-02-19 Meshi Bashari , Yonghoon Lee , Roy Maor Lotan , Edgar Dobriban , Yaniv Romano

In machine learning, likelihood-free inference refers to the task of performing an analysis driven by data instead of an analytical expression. We discuss the application of Neural Spline Flows, a neural density estimation algorithm, to the…

High Energy Physics - Phenomenology · Physics 2020-07-01 Sebastian Pina-Otey , Federico Sánchez , Vicens Gaitan , Thorsten Lux

Many recent works in simulation-based inference (SBI) rely on deep generative models to approximate complex, high-dimensional posterior distributions. However, evaluating whether or not these approximations can be trusted remains a…

Machine Learning · Statistics 2023-10-11 Julia Linhart , Alexandre Gramfort , Pedro L. C. Rodrigues

While fiducial inference was widely considered a big blunder by R.A. Fisher, the goal he initially set --`inferring the uncertainty of model parameters on the basis of observations' -- has been continually pursued by many statisticians. To…

Machine Learning · Statistics 2024-08-01 Faming Liang , Sehwan Kim , Yan Sun

The use of standard statistical methods, such as maximum likelihood, is often justified based on their asymptotic properties. For suitably regular models, this theory is standard but, when the model is non-regular, e.g., the support depends…

Methodology · Statistics 2016-08-25 Ryan Martin , Yi Lin

Generative models and those with computationally intractable likelihoods are widely used to describe complex systems in the natural sciences, social sciences, and engineering. Fitting these models to data requires likelihood-free inference…

Methodology · Statistics 2025-12-04 Rui Zhang , Oksana A. Chkrebtii , Dongbin Xiu

For many stochastic models of interest in systems biology, such as those describing biochemical reaction networks, exact quantification of parameter uncertainty through statistical inference is intractable. Likelihood-free computational…

Molecular Networks · Quantitative Biology 2021-05-10 David J. Warne , Ruth E. Baker , Matthew J. Simpson

We investigate the problem of statistical inference for logistic regression with high-dimensional covariates in settings where dependence among individuals is induced by an underlying Markov random field. Going beyond the pairwise…

Statistics Theory · Mathematics 2026-03-23 Josh Miles , Sohom Bhattacharya

Inferential models (IMs) offer prior-free, Bayesian-like posterior degrees of belief designed for statistical inference, which feature a frequentist-like calibration property that ensures reliability of said inferences. The catch is that…

Computation · Statistics 2025-07-09 Ryan Martin

Our predictions for particle physics processes are realized in a chain of complex simulators. They allow us to generate high-fidelity simulated data, but they are not well-suited for inference on the theory parameters with observed data. We…

High Energy Physics - Phenomenology · Physics 2020-11-03 Johann Brehmer , Kyle Cranmer

Bayesian, frequentist and fiducial (BFF) inferences are much more congruous than they have been perceived historically in the scientific community (cf., Reid and Cox 2015; Kass 2011; Efron 1998). Most practitioners are probably more…

Methodology · Statistics 2022-06-17 Suzanne Thornton , Minge Xie

There is a growing need for the ability to analyse interval-valued data. However, existing descriptive frameworks to achieve this ignore the process by which interval-valued data are typically constructed; namely by the aggregation of…

Methodology · Statistics 2019-03-08 Xin Zhang , Boris Beranger , Scott A. Sisson

Fast and automated inference of binary-lens, single-source (2L1S) microlensing events with sampling-based Bayesian algorithms (e.g., Markov Chain Monte Carlo; MCMC) is challenged on two fronts: high computational cost of likelihood…

Instrumentation and Methods for Astrophysics · Physics 2021-05-19 Keming Zhang , Joshua S. Bloom , B. Scott Gaudi , Francois Lanusse , Casey Lam , Jessica R. Lu

Selection bias arises when the probability that an observation enters a dataset depends on variables related to the quantities of interest, leading to systematic distortions in estimation and uncertainty quantification. For example, in…

Throughout the life sciences we routinely seek to interpret measurements and observations using parameterised mechanistic mathematical models. A fundamental and often overlooked choice in this approach involves relating the solution of a…

Quantitative Methods · Quantitative Biology 2023-11-10 Ryan J. Murphy , Oliver J. Maclaren , Matthew J. Simpson