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Recent advancements have introduced machine learning frameworks to enhance the Branch and Bound (B\&B) branching policies for solving Mixed Integer Linear Programming (MILP). These methods, primarily relying on imitation learning of Strong…

Machine Learning · Computer Science 2024-02-07 Jiacheng Lin , Meng Xu , Zhihua Xiong , Huangang Wang

Our objective is to estimate the unknown compositional input from its output response through an unknown system after estimating the inverse of the original system with a training set. The proposed methods using artificial neural networks…

Machine Learning · Computer Science 2020-01-27 Se Un Park

Nuclear magnetic resonance (NMR) spectroscopy provides an experimental readout of local chemical environments, but its use in molecular representation learning has been constrained by heterogeneous data and incomplete atom-level…

Chemical Physics · Physics 2026-05-12 Jiebin Fang , Zidi Yan , Churu Mao , Yongjun Jiang , Xinyi Tang , Lei Miao , Dan Lu , Yun Huang , Wanjing Ding , Zhongjun Ma

We present a new use of Answer Set Programming (ASP) to discover the molecular structure of chemical samples based on the relative abundance of elements and structural fragments, as measured in mass spectrometry. To constrain the…

Logic in Computer Science · Computer Science 2026-02-25 Nils Küchenmeister , Alex Ivliev , Markus Krötzsch

Robust and efficient interpretation of QSAR methods is quite useful to validate AI prediction rationales with subjective opinion (chemist or biologist expertise), understand sophisticated chemical or biological process mechanisms, and…

Biomolecules · Quantitative Biology 2026-05-05 Jinjiang Guo , Qi Liu , Han Guo , Xi Lu

Mixed-integer linear programs (MILPs) are extensively used to model practical problems such as planning and scheduling. A prominent method for solving MILPs is large neighborhood search (LNS), which iteratively seeks improved solutions…

Optimization and Control · Mathematics 2024-12-12 Wenbo Liu , Akang Wang , Wenguo Yang , Qingjiang Shi

Atomic neural networks (ANNs) constitute a class of machine learning methods for predicting potential energy surfaces and physico-chemical properties of molecules and materials. Despite many successes, developing interpretable ANN…

Computational Physics · Physics 2020-01-17 Yunqi Shao , Matti Hellström , Pavlin D. Mitev , Lisanne Knijff , Chao Zhang

Molecule representation learning (MRL) methods aim to embed molecules into a real vector space. However, existing SMILES-based (Simplified Molecular-Input Line-Entry System) or GNN-based (Graph Neural Networks) MRL methods either take…

Machine Learning · Computer Science 2021-09-23 Hongwei Wang , Weijiang Li , Xiaomeng Jin , Kyunghyun Cho , Heng Ji , Jiawei Han , Martin D. Burke

The IMPRESSION (Intelligent Machine PREdiction of Shift and Scalar Information Of Nuclei) machine learning system provides an efficient and accurate route to the prediction of NMR parameters from 3-dimensional chemical structures. Here we…

We introduce a mixed-integer linear programming (MILP) framework capable of determining whether a chemical reaction network possesses the property of being endotactic or strongly endotactic. The network property of being strongly endotactic…

Numerical Analysis · Mathematics 2014-12-16 Matthew D. Johnston , Casian Pantea , Pete Donnell

Chemists in search of structure-property relationships face great challenges due to limited high quality, concordant datasets. Machine learning (ML) has significantly advanced predictive capabilities in chemical sciences, but these modern…

Machine Learning · Computer Science 2025-09-18 Yulia Pimonova , Michael G. Taylor , Alice Allen , Ping Yang , Nicholas Lubbers

We propose a mixed-integer linear program (MILP) for multi-agent motion planning that embeds Polytopic Action-based Motion Planning (PAAMP) into a sequence-then-solve pipeline. Region sequences confine each agent to adjacent convex…

Robotics · Computer Science 2026-03-19 Akshay Jaitly , Jack Cline , Siavash Farzan

We proposes a novel method that enables Graph Neural Networks (GNNs) to solve SAT problems by leveraging a technique developed for applying GNNs to Mixed Integer Linear Programming (MILP). Specifically, k-CNF formulae are mapped into MILP…

Machine Learning · Computer Science 2025-07-03 Franco Alberto Cardillo , Hamza Khyari , Umberto Straccia

With the recent advances in machine learning for quantum chemistry, it is now possible to predict the chemical properties of compounds and to generate novel molecules. Existing generative models mostly use a string- or graph-based…

Biomolecules · Quantitative Biology 2020-10-14 Vitali Nesterov , Mario Wieser , Volker Roth

With the accelerated development of Industry 4.0, intelligent manufacturing systems increasingly require efficient task allocation and scheduling in multi-robot systems. However, existing methods rely on domain expertise and face challenges…

Artificial Intelligence · Computer Science 2025-03-19 Mingming Peng , Zhendong Chen , Jie Yang , Jin Huang , Zhengqi Shi , Qihao Liu , Xinyu Li , Liang Gao

In machine learning and molecular design, there exist two approaches: discriminative and generative. In the discriminative approach dubbed forward design, the goal is to map a set of features/molecules to their respective electronics…

Chemical Physics · Physics 2019-04-24 Alain Tchagang , Julio Valdés

A major challenge in materials design is how to efficiently search the vast chemical design space to find the materials with desired properties. One effective strategy is to develop sampling algorithms that can exploit both explicit…

Machine Learning · Computer Science 2020-06-30 Yabo Dan , Yong Zhao , Xiang Li , Shaobo Li , Ming Hu , Jianjun Hu

We briefly summarize the kernel regression approach, as used recently in materials modelling, to fitting functions, particularly potential energy surfaces, and highlight how the linear algebra framework can be used to both predict and train…

Computational Physics · Physics 2019-02-05 Michele Ceriotti , Michael J. Willatt , Gábor Csányi

The reverse engineering of a complex mixture, regardless of its nature, has become significant today. Being able to quickly assess the potential toxicity of new commercial products in relation to the environment presents a genuine…

Artificial Intelligence · Computer Science 2023-11-01 Pedro Marote , Marie Martin , Anne Bonhomme , Pierre Lantéri , Yohann Clément

A method which casts the chemical source term computation into an artificial neural network (ANN)-inspired form is presented. This approach is well-suited for use on emerging supercomputing platforms that rely on graphical processing units…

Chemical Physics · Physics 2021-05-11 Shivam Barwey , Venkat Raman