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The design of crystal materials plays a critical role in areas such as new energy development, biomedical engineering, and semiconductors. Recent advances in data-driven methods have enabled the generation of diverse crystal structures.…

Artificial Intelligence · Computer Science 2025-12-12 Chao Huang , Jiahui Chen , Chen Chen , Chen Chen , Chunyan Chen , Renjie Su , Shiyu Du

The generation of plausible crystal structures is often the first step in predicting the structure and properties of a material from its chemical composition. Quickly generating and predicting inorganic crystal structures is important for…

Materials Science · Physics 2024-02-13 Luis M. Antunes , Keith T. Butler , Ricardo Grau-Crespo

Crystal structure prediction has been a subject of topical interest, but remains a substantial challenge, especially for complex structures as it deals with the global minimization of the extremely rugged high-dimensional potential energy…

Materials Science · Physics 2022-01-26 Xuecheng Shao , Jian Lv , Peng Liu , Sen Shao , Pengyue Gao , Hanyu Liu , Yanchao Wang , Yanming Ma

Crystal structure prediction (CSP) is emerging as a powerful method for the computational design of metal-organic frameworks (MOFs). In this article we employ CSP to perform high-throughput exploration of the crystal energy landscape of…

Crystal structure prediction algorithms have become powerful tools for materials discovery in recent years, however, they are usually limited to relatively small systems. The main challenge is that the number of local minima grows…

Materials Science · Physics 2022-02-09 Hao Gao , Junjie Wang , Yu Han , Jian Sun

Crystal structure prediction is a long-standing challenge in materials science, with most data-driven methods developed for inorganic systems. This leaves an important gap for organic crystals, which are central to pharmaceuticals,…

Materials Science · Physics 2026-02-25 Mohammadmahdi Vahediahmar , Matthew A. McDonald , Feng Liu

Computational prediction of stable crystal structures has a profound impact on the large-scale discovery of novel functional materials. However, predicting the crystal structure solely from a material's composition or formula is a promising…

Materials Science · Physics 2024-04-09 Yuqi Song , Rongzhi Dong , Lai Wei , Qin Li , Jianjun Hu

Molecular crystal structure prediction (CSP) seeks the most stable periodic structure given the chemical composition of a molecule and pressure-temperature conditions. Modern CSP solvers use global optimization methods to search for…

Optimization and Control · Mathematics 2023-02-21 Miloslav Torda , John Y. Goulermas , Roland Púček , Vitaliy Kurlin

Crystal structure predictions based on the combination of first-principles calculations and machine learning have achieved significant success in materials science. However, most of these approaches are limited to predicting specific…

Materials Science · Physics 2025-01-28 Zongguo Wang , Ziyi Chen , Yang Yuan , Yangang Wang

Existing Genetic Algorithms for crystal structure and polymorph prediction can suffer from stagnation during evolution, with a consequent loss of efficiency and accuracy. An improved Genetic Algorithm (GA) is introduced herein which…

Materials Science · Physics 2008-05-13 N. L. Abraham , M. I. J. Probert

Organic molecular crystals underpin technologies ranging from pharmaceuticals to organic electronics, yet predicting solid-state packing of molecules remains challenging because candidate generation is combinatorial and stability is only…

A multitude of measures have been proposed to quantify the similarity between protein 3-D structure. Among these measures, contact map overlap (CMO) maximization deserved sustained attention during past decade because it offers a fine…

Quantitative Methods · Quantitative Biology 2009-04-20 Rumen Andonov , Nicola Yanev , Noël Malod-Dognin

We study Crystal Structure Prediction, one of the major problems in computational chemistry. This is essentially a continuous optimization problem, where many different, simple and sophisticated, methods have been proposed and applied. The…

Computational Engineering, Finance, and Science · Computer Science 2020-03-30 Dmytro Antypov , Argyrios Deligkas , Vladimir Gusev , Matthew J. Rosseinsky , Paul G. Spirakis , Michail Theofilatos

First-principles based crystal structure prediction (CSP) methods have revealed an essential tool for the discovery of new materials. However, in solids close to displacive phase transitions, which are common in ferroelectrics,…

Materials Science · Physics 2026-04-17 Hao Gao , Yue-Wen Fang , Ion Errea

Structure is the most basic and important property of crystalline solids; it determines directly or indirectly most materials characteristics. However, predicting crystal structure of solids remains a formidable and not fully solved…

Materials Science · Physics 2021-01-04 Haotong Liang , Valentin Stanev , A. Gilad Kusne , Ichiro Takeuchi

Reliable and robust methods of predicting the crystal structure of a compound, based only on its chemical composition, is crucial to the study of materials and their applications. Despite considerable ongoing research efforts, crystal…

Materials Science · Physics 2017-07-26 Qi-Jun Hong , Joseph Yasi , Axel van de Walle

We present a genetic algorithm (GA) for structural search that combines the speed of structure exploration by classical potentials with the accuracy of density functional theory (DFT) calculations in an adaptive and iterative way. This…

Materials Science · Physics 2015-11-06 S. Q. Wu , M. Ji , C. Z. Wang , M. C. Nguyen , X. Zhao , K. Umemoto , R. M. Wentzcovitch , K. M. Ho

We developed a density functional theory-free approach for crystal structure prediction via combing graph network (GN) and Bayesian optimization (BO). GN is adopted to establish the correlation model between crystal structure and formation…

Materials Science · Physics 2020-11-24 Guanjian Cheng , Xin-Gao Gong , Wan-Jian Yin

In this letter we propose a new methodology for crystal structure prediction, which is based on the evolutionary algorithm USPEX and the machine-learning interatomic potentials actively learning on-the-fly. Our methodology allows for an…

Materials Science · Physics 2019-03-06 Evgeny V. Podryabinkin , Evgeny V. Tikhonov , Alexander V. Shapeev , Artem R. Oganov

The recently developed evolutionary algorithm USPEX proved to be a tool that enables accurate and reliable prediction of structures for a given chemical composition. Here we extend this method to predict the crystal structure of polymers by…

Materials Science · Physics 2019-01-03 Qiang Zhu , Vinit Sharma , Artem R Oganov , Rampi Ramprasad