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Objective: In this paper, we develop a personalized real-time risk scoring algorithm that provides timely and granular assessments for the clinical acuity of ward patients based on their (temporal) lab tests and vital signs; the proposed…

Artificial Intelligence · Computer Science 2016-10-28 Ahmed M. Alaa , Jinsung Yoon , Scott Hu , Mihaela van der Schaar

Estimating how a treatment affects units individually, known as heterogeneous treatment effect (HTE) estimation, is an essential part of decision-making and policy implementation. The accumulation of large amounts of data in many domains,…

Machine Learning · Computer Science 2022-06-28 Christopher Tran , Elena Zheleva

While recommender systems (RSs) traditionally rely on extensive individual user data, regulatory and technological shifts necessitate reliance on aggregated user information. This shift significantly impacts the recommendation process,…

Information Retrieval · Computer Science 2025-02-27 Gur Keinan , Omer Ben-Porat

A key challenge in building effective regression models for large and diverse populations is accounting for patient heterogeneity. An example of such heterogeneity is in health system risk modeling efforts where different combinations of…

Methodology · Statistics 2022-12-26 Jared D. Huling , Menggang Yu

We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy…

Machine Learning · Statistics 2018-12-06 Ruidi Chen , Ioannis Paschalidis

This research presents an examination of categorizing the severity states of patients based on their electronic health records during a certain time range using multiple machine learning and deep learning approaches. The suggested method…

Machine Learning · Computer Science 2022-09-30 A. N. M. Sajedul Alam , Rimi Reza , Asir Abrar , Tanvir Ahmed , Salsabil Ahmed , Shihab Sharar , Annajiat Alim Rasel

Treatment effect heterogeneity refers to the systematic variation in treatment effects across subgroups. There is an increasing need for clinical trials that aim to investigate treatment effect heterogeneity and estimate subgroup-specific…

Methodology · Statistics 2026-03-06 Xianglin Zhao , Shirin Golchi , Jean-Philippe Gouin , Kaberi Dasgupta

The aim of clinical effectiveness research using repositories of electronic health records is to identify what health interventions 'work best' in real-world settings. Since there are several reasons why the net benefit of intervention may…

Methodology · Statistics 2020-06-19 Jie Zhu , Blanca Gallego

A treatment regime formalizes personalized medicine as a function from individual patient characteristics to a recommended treatment. A high-quality treatment regime can improve patient outcomes while reducing cost, resource consumption,…

Methodology · Statistics 2015-04-30 Yichi Zhang , Eric B. Laber , Anastasios Tsiatis , Marie Davidian

Broadening eligibility criteria in cancer trials has been advocated to represent the true patient population more accurately. While the advantages are clear in terms of generalizability and recruitment, novel dose-finding designs are needed…

Applications · Statistics 2023-01-12 Rebecca B. Silva , Bin Cheng , Richard D. Carvajal , Shing M. Lee

Identifying patient subgroups with different treatment responses is an important task to inform medical recommendations, guidelines, and the design of future clinical trials. Existing approaches for treatment effect estimation primarily…

Methodology · Statistics 2025-12-10 Vincent Jeanselme , Chang Ho Yoon , Fabian Falck , Brian Tom , Jessica Barrett

As the ageing population grows, older adults increasingly rely on wearable devices to monitor chronic conditions. However, conventional health data representations (HDRs) often present accessibility challenges, particularly for critical…

Human-Computer Interaction · Computer Science 2025-09-16 Peterson Jean , Emma Murphy , Enda Bates

Radiology reports provide detailed descriptions of medical imaging integrated with patients' medical histories, while report writing is traditionally labor-intensive, increasing radiologists' workload and the risk of diagnostic errors.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Fuying Wang , Shenghui Du , Lequan Yu

There is a mounting crisis in delivering affordable healthcare in the US. For decades, key decision makers in the public and private sectors have considered cost-effectiveness in healthcare a top priority. Their actions have focused on…

Current machine learning models aiming to predict sepsis from Electronic Health Records (EHR) do not account for the heterogeneity of the condition, despite its emerging importance in prognosis and treatment. This work demonstrates the…

Quantitative Methods · Quantitative Biology 2020-11-24 Zina Ibrahim , Honghan Wu , Ahmed Hamoud , Lukas Stappen , Richard Dobson , Andrea Agarossi

When devising a course of treatment for a patient, doctors often have little quantitative evidence on which to base their decisions, beyond their medical education and published clinical trials. Stanford Health Care alone has millions of…

Depression and anxiety are critical public health issues affecting millions of people around the world. To identify individuals who are vulnerable to depression and anxiety, predictive models have been built that typically utilize data from…

Social and Information Networks · Computer Science 2020-01-14 Shikang Liu , Fatemeh Vahedian , David Hachen , Omar Lizardo , Christian Poellabauer , Aaron Striegel , Tijana Milenkovic

We study a fundamental model of resource allocation in which a finite number of resources must be assigned in an online manner to a heterogeneous stream of customers. The customers arrive randomly over time according to known stochastic…

Optimization and Control · Mathematics 2018-05-16 Clifford Stein , Van-Anh Truong , Xinshang Wang

Generative Recommenders (GRs), exemplified by the Hierarchical Sequential Transduction Unit (HSTU), have emerged as a powerful paradigm for modeling long user interaction sequences. However, we observe that their "flat-sequence" assumption…

Information Retrieval · Computer Science 2026-03-03 Zerui Chen , Heng Chang , Tianying Liu , Chuantian Zhou , Yi Cao , Jiandong Ding , Ming Liu , Bing Qin

We propose Causal Interaction Trees for identifying subgroups of participants that have enhanced treatment effects using observational data. We extend the Classification and Regression Tree algorithm by using splitting criteria that focus…

Methodology · Statistics 2021-12-08 Jiabei Yang , Issa J. Dahabreh , Jon A. Steingrimsson
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