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Deep learning-based approaches, such as AlphaFold2 (AF2), have significantly advanced protein tertiary structure prediction, achieving results comparable to real biological experimental methods. While AF2 has shown limitations in predicting…

Biomolecules · Quantitative Biology 2025-01-23 Zhongju Yuan , Tao Shen , Sheng Xu , Leiye Yu , Ruobing Ren , Siqi Sun

Federated Learning (FL) enables multiple resource-constrained edge devices with varying levels of heterogeneity to collaboratively train a global model. However, devices with limited capacity can create bottlenecks and slow down model…

Machine Learning · Computer Science 2025-04-08 Afsaneh Mahanipour , Hana Khamfroush

The analysis of speech measures in individuals with amyotrophic lateral sclerosis (ALS) can provide essential information for early diagnosis and tracking disease progression. However, current methods for extracting speech and pause…

Sound · Computer Science 2022-08-24 Saeid Alavi Naeini , Leif Simmatis , Yana Yunusova , Babak Taati

We consider the problem of testing whether pairs of univariate random variables are associated. Few tests of independence exist that are consistent against all dependent alternatives and are distribution free. We propose novel tests that…

Methodology · Statistics 2014-12-09 Ruth Heller , Yair Heller , Shachar Kaufman , Malka Gorfine

Activation functions (AFs) play a pivotal role in the performance of neural networks. The Rectified Linear Unit (ReLU) is currently the most commonly used AF. Several replacements to ReLU have been suggested but improvements have proven…

Neural and Evolutionary Computing · Computer Science 2022-06-27 Raz Lapid , Moshe Sipper

The sequence length along the time axis is often the dominant factor of the computation in speech processing. Works have been proposed to reduce the sequence length for lowering the computational cost in self-supervised speech models.…

Computation and Language · Computer Science 2023-05-10 Hsuan-Jui Chen , Yen Meng , Hung-yi Lee

The effectiveness of modern deep learning models is predicated on the availability of large-scale, human-annotated datasets, a process that is notoriously expensive and time-consuming. While Active Learning (AL) offers a strategic solution…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Yuxi Liu , Catherine Lalman , Yimin Yang

Large language models (LLMs) often benefit from verbalized reasoning at inference time, but it remains unclear which aspects of task difficulty these extra reasoning tokens address. To investigate this question, we formalize a framework…

Artificial Intelligence · Computer Science 2025-04-03 Celine Lee , Alexander M. Rush , Keyon Vafa

This paper proposes an active learning (AL) algorithm to solve regression problems based on inverse-distance weighting functions for selecting the feature vectors to query. The algorithm has the following features: (i) supports both…

Machine Learning · Computer Science 2022-12-15 Alberto Bemporad

Variable selection properties of procedures utilizing penalized-likelihood estimates is a central topic in the study of high dimensional linear regression problems. Existing literature emphasizes the quality of ranking of the variables by…

Statistics Theory · Mathematics 2022-04-28 Asaf Weinstein , Weijie J. Su , Małgorzata Bogdan , Rina F. Barber , Emmanuel J. Candès

One of the most intriguing results of single molecule experiments on proteins and nucleic acids is the discovery of functional heterogeneity: the observation that complex cellular machines exhibit multiple, biologically active…

Biomolecules · Quantitative Biology 2022-10-12 Michael Hinczewski , Changbong Hyeon , D. Thirumalai

The alignment of large language models (LLMs) aims to ensure their outputs adhere to human values, ethical standards, and legal norms. Traditional alignment methods often rely on resource-intensive fine-tuning (FT), which may suffer from…

Computation and Language · Computer Science 2025-09-11 Birong Pan , Yongqi Li , Weiyu Zhang , Wenpeng Lu , Mayi Xu , Shen Zhou , Yuanyuan Zhu , Ming Zhong , Tieyun Qian

Existing large language models (LLMs) evaluations use fixed-difficulty benchmarks that cannot adapt as models improve, and rarely isolate specific cognitive processes. We introduce Working Memory Fidelity-Active Manipulation (WMF-AM), a…

Artificial Intelligence · Computer Science 2026-05-05 Dengzhe Hou , Lingyu Jiang , Deng Li , Zirui Li , Fangzhou Lin , Kazunori D Yamada

Autoformalization addresses the scarcity of data for Automated Theorem Proving (ATP) by translating mathematical problems from natural language into formal statements. Efforts in recent work shift from directly prompting large language…

Artificial Intelligence · Computer Science 2025-10-09 Qi Guo , Jianing Wang , Jianfei Zhang , Deyang Kong , Xiangzhou Huang , Xiangyu Xi , Wei Wang , Jingang Wang , Xunliang Cai , Shikun Zhang , Wei Ye

One way to interpret trained deep neural networks (DNNs) is by inspecting characteristics that neurons in the model respond to, such as by iteratively optimising the model input (e.g., an image) to maximally activate specific neurons.…

Machine Learning · Computer Science 2019-07-02 Saumitra Mishra , Daniel Stoller , Emmanouil Benetos , Bob L. Sturm , Simon Dixon

We introduce a new concept, the APN-defect, which can be thought of as measuring the distance of a given function $G:\mathbb{F}_{2^n} \rightarrow \mathbb{F}_{2^n}$ to the set of almost perfect nonlinear (APN) functions. This concept is…

Information Theory · Computer Science 2024-06-12 Nurdagül Anbar , Tekgül Kalaycı , Alev Topuzoğlu

Classifier-free guidance (CFG) has become an essential component of modern conditional diffusion models. Although highly effective in practice, the underlying mechanisms by which CFG enhances quality, detail, and prompt alignment are not…

Machine Learning · Computer Science 2025-06-25 Seyedmorteza Sadat , Tobias Vontobel , Farnood Salehi , Romann M. Weber

Interest in functional time series has spiked in the recent past with papers covering both methodology and applications being published at a much increased pace. This article contributes to the research in this area by proposing a new…

Methodology · Statistics 2019-11-21 Alexander Aue , Anne van Delft

We analytically investigate size and power properties of a popular family of procedures for testing linear restrictions on the coefficient vector in a linear regression model with temporally dependent errors. The tests considered are…

Statistics Theory · Mathematics 2015-05-12 David Preinerstorfer

Testing independence is of significant interest in many important areas of large-scale inference. Using extreme-value form statistics to test against sparse alternatives and using quadratic form statistics to test against dense alternatives…

Statistics Theory · Mathematics 2015-12-31 Danning Li , Lingzhou Xue