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Multispectral computed tomography (CT) enables advanced material characterization by acquiring energy-resolved projection data. However, since the incoming X-ray flux is be distributed across multiple narrow energy bins, the photon count…

Short-scan FDK reconstruction is widely used in preclinical cone-beam micro-CT because it reduces scan time and radiation dose, and because the large volume sizes typical of micro-CT make iterative methods impractical for routine use. Short…

Medical Physics · Physics 2026-04-28 Falk L Wiegmann , Nancy L Ford

Existing methods in nanoscale connectomics are at present too slow to map entire mammalian brains. As an emerging approach, expansion microscopy (ExM) has enormous promise, yet it still suffers from throughput limitations. Mapping the human…

Quantitative Methods · Quantitative Biology 2026-01-21 Logan Thrasher Collins

We introduce a revised derivation of the bitwise Markov Chain Monte Carlo (MCMC) multiple-input multiple-output (MIMO) detector. The new approach resolves the previously reported high SNR stalling problem of MCMC without the need for…

Information Theory · Computer Science 2017-07-13 Jonathan C. Hedstrom , Chung Him , Yuen , Rong-Rong Chen , Behrouz Farhang-Boroujeny

Phase-contrast and dark-field imaging are relatively new X-ray imaging modalities that provide additional information to conventional attenuation-based imaging. However, this new information comes at the price of a more complex acquisition…

X-ray tomography is a reliable tool for determining the inner structure of 3D object with penetrating X-rays. However, traditional reconstruction methods such as FDK require dense angular sampling in the data acquisition phase leading to…

X-ray Computed Tomography (CT) reconstruction from a sparse number of views is a useful way to reduce either the radiation dose or the acquisition time, for example in fixed-gantry CT systems, however this results in an ill-posed inverse…

Data Structures and Algorithms · Computer Science 2020-11-04 Alessandro Perelli , Michael Lexa , Ali Can , Mike E. Davies

Cross-grating phase microscopy (CGM) is a quantitative phase microscopy technique based on the association of a 2-dimensional diffraction grating (cross-grating) and a regular camera sensor, separated by a millimetric distance. This simple…

Optics · Physics 2024-11-04 Baptiste Marthy , Guillaume Baffou

X-ray single particle imaging involves the measurement of a large number of noisy diffraction patterns of isolated objects in random orientations. The missing information about these patterns is then computationally recovered in order to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Kartik Ayyer

X-ray computed tomography (XCT) is a key tool in non-destructive evaluation of additively manufactured (AM) parts, allowing for internal inspection and defect detection. Despite its widespread use, obtaining high-resolution CT scans can be…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Haley Duba-Sullivan , Obaidullah Rahman , Singanallur Venkatakrishnan , Amirkoushyar Ziabari

We present an optical metrology system for characterization of topography of micro/nano-structures on a surface or embedded in a semi-transparent material. Based on the principles of scatterometry, where the intensity of scattered light is…

Instrumentation and Detectors · Physics 2016-01-15 Morten Hannibal Madsen , Poul-Erik Hansen

Computed tomography (CT) has been used worldwide as a non-invasive test to assist in diagnosis. However, the ionizing nature of X-ray exposure raises concerns about potential health risks such as cancer. The desire for lower radiation doses…

Image and Video Processing · Electrical Eng. & Systems 2024-07-01 Yucheng Lu , Zhixin Xu , Moon Hyung Choi , Jimin Kim , Seung-Won Jung

Cone-beam computed tomography (CBCT) has been widely used in medical imaging and industrial nondestructive testing, but the presence of scattered radiation will cause significant reduction of image quality. In this article, a robust scatter…

Medical Physics · Physics 2016-08-03 Kuidong Huang , Zhe Xu , Dinghua Zhang , Hua Zhang , Wenlong Shi

X-ray Computed Laminography (CL) is essential for non-destructive inspection of plate-like structures in applications such as microchips and composite battery materials, where traditional computed tomography (CT) struggles due to geometric…

Computer Vision and Pattern Recognition · Computer Science 2025-09-18 Chu Chen , Ander Biguri , Jean-Michel Morel , Raymond H. Chan , Carola-Bibiane Schönlieb , Jizhou Li

Low dose computed tomography (LDCT) has attracted more and more attention in routine clinical diagnosis assessment, therapy planning, etc., which can reduce the dose of X-ray radiation to patients. However, the noise caused by low X-ray…

Image and Video Processing · Electrical Eng. & Systems 2021-07-06 Zhicheng Zhang , Lequan Yu , Xiaokun Liang , Wei Zhao , Lei Xing

This paper presents a method for improved analysis of objects with an axial symmetry using X-ray Computed Tomography (CT). Cylindrical coordinates about an axis fixed to the object form the most natural base to check certain characteristics…

Image and Video Processing · Electrical Eng. & Systems 2020-10-06 Wannes Goethals , Marjolein Heyndrickx , Matthieu Boone

In scanning electron microscopy, the achievable image quality is often limited by a maximum feasible acquisition time per dataset. Particularly with regard to three-dimensional or large field-of-view imaging, a compromise must be found…

Computer Vision and Pattern Recognition · Computer Science 2018-01-15 Patrick Trampert , Faysal Bourghorbel , Pavel Potocek , Maurice Peemen , Christian Schlinkmann , Tim Dahmen , Philipp Slusallek

Multi-energy CT has long demonstrated its ability to enhance image quality with material decomposition. Yet, it has largely been limited to applications that already have high contrast. More recently, x-ray phase-contrast (XPC) imaging has…

Medical Physics · Physics 2025-08-19 Giavanna Jadick , Patrick La Rivière

X-ray computed tomography (CT) is one of widely used diagnostic tools for medical and dental tomographic imaging of the human body. However, the standard filtered backprojection reconstruction method requires the complete knowledge of the…

Numerical Analysis · Mathematics 2016-02-24 Jae Kyu Choi , Bin Dong , Xiaoqun Zhang

While drastic improvements in CT technology have occurred in the past 25 years, spatial resolution is one area where progress has been limited until recently. New photon counting CT systems, are capable of much better spatial resolution…

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