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The regulation of the cell state is a complex process involving several components. These complex dynamics can be modeled using Boolean networks, allowing us to explain the existence of different cell states and the transition between them.…

Molecular Networks · Quantitative Biology 2010-01-28 Elke K. Markert , Nils Baas , Arnold J. Levine , Alexei Vazquez

We provide the first classification of different types of Random Boolean Networks (RBNs). We study the differences of RBNs depending on the degree of synchronicity and determinism of their updating scheme. For doing so, we first define…

Computational Complexity · Computer Science 2007-05-23 Carlos Gershenson

This paper studies synchronization in coupled nonlinear dynamic networks with unknown parameters. Adaptation can be added to one or several elements in the network, while preserving the global synchronization conditions derived in…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Wei Wang , Jean-Jacques E. Slotine

There is an obvious need for improving the performance and accuracy of a Bayesian network as new data is observed. Because of errors in model construction and changes in the dynamics of the domains, we cannot afford to ignore the…

Artificial Intelligence · Computer Science 2013-02-08 Nir Friedman , Moises Goldszmidt

Boolean networks are one of the most studied discrete models in the context of the study of gene expression. In order to define the dynamics associated to a Boolean network, there are several \emph{update schemes} that range from parallel…

Formal Languages and Automata Theory · Computer Science 2019-01-29 Eric Goles , Pedro Montealegre , Martín Ríos Wilson

A new probabilistic network construction system, DYNASTY, is proposed for diagnostic reasoning given variables whose probabilities change over time. Diagnostic reasoning is formulated as a sequential stochastic process, and is modeled using…

Artificial Intelligence · Computer Science 2013-03-26 Gregory M. Provan

A Boolean network is a finite state discrete time dynamical system. At each step, each variable takes a value from a binary set. The value update rule for each variable is a local function which depends only on a selected subset of…

Dynamical Systems · Mathematics 2017-08-10 Zuguang Gao , Xudong Chen , Tamer Başar

Boolean networks have been used in a variety of settings, as models for general complex systems as well as models of specific systems in diverse fields, such as biology, engineering, and computer science. Traditionally, their properties as…

Dynamical Systems · Mathematics 2024-02-02 Matthew Wheeler , Claus Kadelka , Alan Veliz-Cuba , David Murrugarra , Reinhard Laubenbacher

We compare asynchronous vs. synchronous update of discrete dynamical networks and find that a simple time delay in the nodes may induce a reproducible deterministic dynamics even in the case of asynchronous update in random order. In…

Molecular Networks · Quantitative Biology 2007-05-23 Konstantin Klemm , Stefan Bornholdt

Random Boolean networks (RBNs) are models of genetic regulatory networks. It is useful to describe RBNs as self-organizing systems to study how changes in the nodes and connections affect the global network dynamics. This article reviews…

Adaptation and Self-Organizing Systems · Physics 2010-09-24 Carlos Gershenson

Dialectical frameworks are a unifying model of formal argumentation, where argumentative relations between arguments are represented by assigning acceptance conditions to atomic arguments. Their generality allow them to cover a number of…

Artificial Intelligence · Computer Science 2024-07-03 Jesse Heyninck , Matthias Knorr , João Leite

Boolean networks may be viewed as idealizations of biological genetic networks, where each node is represented by an on-off switch which is a function of the binary output from some other nodes. We evolve connectivity in a single Boolean…

Biological Physics · Physics 2016-09-08 Stefan Bornholdt , Kim Sneppen

We study the stability of orbits in large Boolean networks with given complex topology. We impose no restrictions on the form of the update rules, which may be correlated with local topological properties of the network. While recent past…

Physics and Society · Physics 2014-09-05 Shane Squires , Andrew Pomerance , Michelle Girvan , Edward Ott

Canalization is a classic concept in Developmental Biology that is thought to be an important feature of evolving systems. In a Boolean network it is a form of network robustness in which a subset of the input signals control the behavior…

Molecular Networks · Quantitative Biology 2015-05-28 Matthew D. Reichl , Kevin E. Bassler

We formulate the predicted-updates dynamic model, one of the first beyond-worst-case models for dynamic algorithms, which generalizes a large set of well-studied dynamic models including the offline dynamic, incremental, and decremental…

Data Structures and Algorithms · Computer Science 2023-11-29 Quanquan C. Liu , Vaidehi Srinivas

The dynamical organization in the presence of noise of a Boolean neural network with random connections is analyzed. For low levels of noise, the system reaches a stationary state in which the majority of its elements acquire the same…

Disordered Systems and Neural Networks · Physics 2007-05-23 Cristian Huepe , Maximino Aldana

Boolean networks have been proposed as potentially useful models for genetic control. An important aspect of these networks is the stability of their dynamics in response to small perturbations. Previous approaches to stability have assumed…

Molecular Networks · Quantitative Biology 2015-05-13 Andrew Pomerance , Edward Ott , Michelle Girvan , Wolfgang Losert

Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions (from molecules in gene regulatory…

Molecular Networks · Quantitative Biology 2023-10-20 Jordan C. Rozum , Colin Campbell , Eli Newby , Fatemeh Sadat Fatemi Nasrollahi , Reka Albert

We describe systems using Kauffman and similar networks. They are directed funct ioning networks consisting of finite number of nodes with finite number of discr ete states evaluated in synchronous mode of discrete time. In this paper we…

Disordered Systems and Neural Networks · Physics 2009-11-13 Andrzej Gecow

We propose new activity-dependent adaptive Boolean networks inspired by the cis-regulatory mechanism in gene regulatory networks. We analytically show that our model can be solved for stationary in-degree distribution for a wide class of…

Adaptation and Self-Organizing Systems · Physics 2017-12-08 Taichi Haruna