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Clinical trials with time-to-event endpoints, such as overall survival (OS) or progression-free survival (PFS), are fundamental for evaluating new treatments, particularly in immuno-oncology. However, modern therapies, such as…

Methodology · Statistics 2025-09-10 James Salsbury , Jeremy Oakley , Steven Julious , Lisa Hampson

This paper presents a real time, data driven decision support framework for epidemic control. We combine a compartmental epidemic model with sequential Bayesian inference and reinforcement learning (RL) controllers that adaptively choose…

Methodology · Statistics 2025-11-25 Giacomo Iannucci , Petros Barmpounakis , Alexandros Beskos , Nikolaos Demiris

Project scheduling in manufacturing environments often requires flexibility in terms of the selection and the exact length of alternative production activities. Moreover, the simultaneous scheduling of multiple lots is mandatory in many…

Artificial Intelligence · Computer Science 2020-10-26 Viktoria A. Hauder , Andreas Beham , Sebastian Raggl , Sophie N. Parragh , Michael Affenzeller

Monitoring key elements of disease dynamics (e.g., prevalence, case counts) is of great importance in infectious disease prevention and control, as emphasized during the COVID-19 pandemic. To facilitate this effort, we propose a new…

Methodology · Statistics 2024-10-10 Lin Ge , Yuzi Zhang , Lance A. Waller , Robert H. Lyles

Under the Dynamic Resource Allocation (DRA) model, an administrator has the mission to allocate dynamically a limited budget of resources to the nodes of a network in order to reduce a diffusion process (DP) (e.g. an epidemic). The standard…

Systems and Control · Electrical Eng. & Systems 2019-09-24 Mathilde Fekom , Nicolas Vayatis , Argyris Kalogeratos

Emerging in December 2019, the COVID-19 pandemic caused widespread health, economic, and social disruptions. Rapid global transmission overwhelmed healthcare systems, resulting in high infection rates, hospitalisations, and fatalities. To…

Populations and Evolution · Quantitative Biology 2025-10-08 Zacharias Komodromos , Kleanthis Malialis , Panayiotis Kolios

There is a constant need for many healthcare programs to timely address problems with infection prevention and control (IP&C). For example, pathogens can be transmitted among patients with cystic fibrosis (CF) in both the inpatient and…

Methodology · Statistics 2022-07-27 Xiaotong Jiang , William Stoudemire , Marianne S. Muhlebach , Michael R. Kosorok

We present a data-driven approach for distributionally robust chance constrained optimization problems (DRCCPs). We consider the case where the decision maker has access to a finite number of samples or realizations of the uncertainty. The…

Optimization and Control · Mathematics 2018-10-11 Ashish R. Hota , Ashish Cherukuri , John Lygeros

We study critical systems that allocate scarce resources to satisfy basic needs, such as homeless services that provide housing. These systems often support communities disproportionately affected by systemic racial, gender, or other…

Computers and Society · Computer Science 2022-12-06 Nathanael Jo , Bill Tang , Kathryn Dullerud , Sina Aghaei , Eric Rice , Phebe Vayanos

In the advent of the novel coronavirus epidemic since December 2019, governments and authorities have been struggling to make critical decisions under high uncertainty at their best efforts. Composite Monte-Carlo (CMC) simulation is a…

Artificial Intelligence · Computer Science 2020-03-24 Simon James Fong , Gloria Li , Nilanjan Dey , Ruben Gonzalez Crespo , Enrique Herrera-Viedma

Machine learning is increasingly used to select which individuals receive limited-resource interventions in domains such as human services, education, development, and more. However, it is often not apparent what the right quantity is for…

Machine Learning · Computer Science 2025-03-20 Vibhhu Sharma , Bryan Wilder

The nodes in communication networks are possibly and most likely equipped with different recovery resources, which allow them to recover from a virus with different rates. In this paper, we aim to understand know how to allocate the limited…

Physics and Society · Physics 2014-09-01 Bo Qu , Alan Hanjalic , Huijuan Wang

Blood transfusion is one of the most crucial and commonly administered therapeutics worldwide. The need for more accurate and efficient ways to manage blood demand and supply is an increasing concern. Building a technology-based, robust…

Applications · Statistics 2021-03-11 Na Li , Fei Chiang , Douglas G. Down , Nancy M. Heddle

Calibration of a SIR (Susceptibles-Infected-Recovered) model with official international data for the COVID-19 pandemics provides a good example of the difficulties inherent the solution of inverse problems. Inverse modeling is set up in a…

Populations and Evolution · Quantitative Biology 2020-06-09 Mauro Giudici , Alessandro Comunian , Romina Gaburro

Because of the rapid spread of COVID-19 to almost every part of the globe, huge volumes of data and case studies have been made available, providing researchers with a unique opportunity to find trends and make discoveries like never…

Machine Learning · Computer Science 2021-10-20 Sarwan Ali , Yijing Zhou , Murray Patterson

As machine learning models become increasingly integrated into healthcare, structural inequities and social biases embedded in clinical data can be perpetuated or even amplified by data-driven models. In survival analysis, censoring and…

Resource allocation under uncertainty is a classical problem in city-scale cyber-physical systems. Consider emergency response as an example; urban planners and first responders optimize the location of ambulances to minimize expected…

Multiagent Systems · Computer Science 2021-12-22 Geoffrey Pettet , Ayan Mukhopadhyay , Mykel J. Kochenderfer , Abhishek Dubey

In this paper we provide a mathematical programming based decision tool to optimally reallocate and share equipments between different units in emergency situations under lack of resources. The approach is motivated by the COVID-19 pandemic…

Optimization and Control · Mathematics 2024-09-11 Víctor Blanco , Ricardo Gázquez , Marina Leal

In this paper we propose a method for sparse dynamic allocation of resources to bound the risk of spreading processes, such as epidemics and wildfires, using convex optimization and dynamic programming techniques. Here, risk is defined as…

Systems and Control · Electrical Eng. & Systems 2021-10-18 Vera L. J. Somers , Ian R. Manchester

In this paper, we introduce a new control-theoretic paradigm for mitigating the spread of a virus. To this end, our discrete-time controller, aims to reduce the number of new daily deaths, and consequently, the cumulative number of deaths.…

Populations and Evolution · Quantitative Biology 2020-08-17 Kevin Burke , B. Ross Barmish
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