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Groups of eukaryotic cilia and flagella are capable of coordinating their beating over large scales, routinely exhibiting collective dynamics in the form of metachronal waves. The origin of this behaviour -- possibly influenced by both…
We derive a continuum mechanical model to capture the morphological changes occurring at the pretumoral stage of epithelial tissues. The proposed model aims to investigate the competition between the bulk elasticity of the epithelium and…
Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to…
A phenomenological model of self-organization explaining the emergence of a complexity with features that apparently satisfy the specific criteria usually required for recognizing the appearance of life in laboratory is presented. The…
The complex physicochemical structures and chemical reactions in living organism have some common features: (1) The life processes take place in the cytosol in the cells, which, from a physicochemical point of view is an emulsion of…
In order to better understand the mechanisms underlying the physiology of vision, it is a necessary prerequisite to know the embryological bases of eye development and associated tissues. Eye formation starts during the fourth week of human…
Many of the intriguing properties of blood originate from its cellular nature. Bulk effects, such as viscosity, depend on the local shear rates and on the size of the vessels. While empirical descriptions of bulk rheology are available for…
The recent discovery of a lateral organization in cell membranes due to small structures called 'rafts' has motivated a lot of biological and physico-chemical studies. A new experiment on a model system has shown a spectacular budding…
We prove results on existence and uniqueness of solutions of a system of equations modeling the evolution of a generalized bioconvective flow. The mathematical model considered in the present work describes the convective motion generated…
Cytasters have been underestimated in terms of their potential relevance to embryonic development and evolution. From the perspective discussed herein, structures such as the multiciliated cells of comb rows and balancers supporting…
The fundamental biological processes of development of tissues and organs in multicellular organisms is governed by various signaling molecules, which are called morphogens. It is known that spatial and temporal variations in concentration…
Left-right symmetry breaking is critical to vertebrate embryonic development; in many species this process begins with cilia-driven flow in a structure termed the `node'. Primary `whirling' cilia, tilted towards the posterior, transport…
Tissue fluidity regulates many critical biological processes, including embryonic development, wound healing, and cancer metastasis. In confluent epithelia, where cell packing fraction is effectively fixed, the prevailing paradigm…
Flagellar-driven locomotion plays a critical role in bacterial attachment and colonization of surfaces, contributing to the risks of contamination and infection. Tremendous attempts to uncover the underlying principles governing bacterial…
Organismal phenotypes emerge from a complex set of genotypic interactions. While technological advances in sequencing provide a quantitative description of an organism's genotype, characterization of an organism's physical phenotype lags…
Embryonic healing in epithelial tissues is distinct from adult wound healing, as it lacks inflammatory responses or immune cell recruitments, making it ideal to test models of wound healing driven primarily by epithelial dynamics. Many…
We study a physical model for the formation of bud-like invaginations on fluid membranes under tension, and apply this model to caveolae formation. We demonstrate that budding can be driven by membrane-bound inclusions (proteins) provided…
Bicontinuous Pickering emulsions (bijels) are a physically interesting class of soft materials with many potential applications including catalysis, microfluidics and tissue engineering. They are created by arresting the spinodal…
Morphogenesis, the process of growth and shape formation in biological tissues, is driven by complex interactions between mechanical, biochemical, and genetic factors. Traditional models of biological growth often rely on the concept of…
Biofilms are microbial collectives that occupy a diverse array of surfaces. The function and evolution of biofilms are strongly influenced by the spatial arrangement of different strains and species within them, but how spatiotemporal…