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Life science is entering a new era of petabyte-level sequencing data. Converting such big data to biological insights represents a huge challenge for computational analysis. To this end, we developed DeepMetabolism, a biology-guided deep…

Genomics · Quantitative Biology 2017-05-10 Weihua Guo , You Xu , Xueyang Feng

A full-fledged data exploration system must combine different access modalities with a powerful concept of guiding the user in the exploration process, by being reactive and anticipative both for data discovery and for data linking. Such…

Multiplexed immunofluorescence provides an unprecedented opportunity for studying specific cell-to-cell and cell microenvironment interactions. We employ graph neural networks to combine features obtained from tissue morphology with…

Graph mining to extract interesting components has been studied in various guises, e.g., communities, dense subgraphs, cliques. However, most existing works are based on notions of frequency and connectivity and do not capture subjective…

Social and Information Networks · Computer Science 2016-08-15 Hao Wu , Maoyuan Sun , Jilles Vreeken , Nikolaj Tatti , Chris North , Naren Ramakrishnan

The rapid growth of publicly available textual resources, such as lexicons and domain-specific corpora, presents challenges in efficiently identifying relevant resources. While repositories are emerging, they often lack advanced search and…

Databases · Computer Science 2025-08-01 Anaïs Ollagnier , Aline Menin

Temporal (or time-evolving) networks are commonly used to model complex systems and the evolution of their components throughout time. Although these networks can be analyzed by different means, visual analytics stands out as an effective…

Human-Computer Interaction · Computer Science 2022-10-06 Claudio D. G. Linhares , Jean R. Ponciano , Diogenes S. Pedro , Luis E. C. Rocha , Agma J. M. Traina , Jorge Poco

Visual design is an essential application of state-of-the-art multi-modal AI systems. Improving these systems requires high-quality vision-language data at scale. Despite the abundance of internet image and text data, knowledge-rich and…

Machine Learning · Computer Science 2026-03-16 Zixin Wen , Yifu Cai , Kyle Lee , Sam Estep , Josh Sunshine , Aarti Singh , Yuejie Chi , Wode Ni

Understanding the response of an output variable to multi-dimensional inputs lies at the heart of many data exploration endeavours. Topology-based methods, in particular Morse theory and persistent homology, provide a useful framework for…

Graphics · Computer Science 2022-08-16 Yarden Livnat , Dan Maljovec , Attila Gyulassy , Dr Baptiste Mouginot , Valerio Pascucci

Effective data visualization is a key part of the discovery process in the era of big data. It is the bridge between the quantitative content of the data and human intuition, and thus an essential component of the scientific path from data…

Discovering valuable insights from data through meaningful associations is a crucial task. However, it becomes challenging when trying to identify representative patterns in quantitative databases, especially with large datasets, as…

Databases · Computer Science 2024-10-31 Lamine Diop , Marc Plantevit

Large-scale vector mapping is important for transportation, city planning, and survey and census. We propose GraphMapper, a unified framework for end-to-end vector map extraction from satellite images. Our key idea is a novel unified…

Computer Vision and Pattern Recognition · Computer Science 2022-11-15 Lei Wang , Min Dai , Jianan He , Jingwei Huang , Mingwei Sun

Biological phenotypes are products of complex evolutionary processes in which selective forces influence multiple biological trait measurements in unknown ways. Phylogenetic factor analysis disentangles these relationships across the…

With the emergence of graph databases, the task of frequent subgraph discovery has been extensively addressed. Although the proposed approaches in the literature have made this task feasible, the number of discovered frequent subgraphs is…

Databases · Computer Science 2013-08-16 Wajdi Dhifli , Mohamed Moussaoui , Rabie Saidi , Engelbert Mephu Nguifo

Motivation: Molecular interaction networks summarize complex biological processes as graphs, whose structure is informative of biological function at multiple scales. Simultaneously, omics technologies measure the variation or activity of…

Quantitative Methods · Quantitative Biology 2020-12-24 Ramin Hasibi , Tom Michoel

We present here a browser-based application for visualizing patterns of connectivity in 3D stacked data matrices with large numbers of pairwise relations. Visualizing a connectivity matrix, looking for trends and patterns, and dynamically…

Neurons and Cognition · Quantitative Biology 2018-01-04 David J. Caldwell , Jing Wu , Kaitlyn Casimo , Jeffrey G. Ojemann , Rajesh P. N. Rao

Intermediate feature representations represent the backbone for the expressivity and adaptability of deep neural networks. However, their geometric structure remains poorly understood. In this submission, we provide indirect insights into…

Machine Learning · Computer Science 2026-05-13 Elias B. Krey , Nils Neukirch , Nils Strodthoff

Current molecular generative models primarily focus on improving drug-target binding affinity and specificity, often neglecting the system-level phenotypic effects elicited by compounds. Transcriptional profiles, as molecule-level readouts…

Chemical Physics · Physics 2025-09-29 Ran Song , Hui Liu

In today's world of big data, computational analysis has become a key driver of biomedical research. Recent exponential growth in the volume of available omics data has reshaped the landscape of contemporary biology, creating demand for a…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-12-09 Jaqueline J. Brito , Thiago Mosqueiro , Jeremy Rotman , Victor Xue , Douglas J. Chapski , Juan De la Hoz , Paulo Matias , Lana Martin , Alex Zelikovsky , Matteo Pellegrinni , Serghei Mangul

The central nervous system is composed of many individual units -- from cells to areas -- that are connected with one another in a complex pattern of functional interactions that supports perception, action, and cognition. One natural and…

Neurons and Cognition · Quantitative Biology 2017-04-03 Ann E. Sizemore , Danielle S. Bassett

Many visualization techniques have been created to explain the behavior of computer vision models, but they largely consist of static diagrams that convey limited information. Interactive visualizations allow users to more easily interpret…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Devon Ulrich , Ruth Fong
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