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Multimodal protein language models deliver strong performance on mutation-effect prediction, but training such models from scratch demands substantial computational resources. In this paper, we propose a fine-tuning framework called…

Quantitative Methods · Quantitative Biology 2026-02-02 Junde Xu , Yapin Shi , Lijun Lang , Taoyong Cui , Zhiming Zhang , Guangyong Chen , Jiezhong Qiu , Pheng-Ann Heng

AI accelerator processing capabilities and memory constraints largely dictate the scale in which machine learning workloads (e.g., training and inference) can be executed within a desirable time frame. Training a state of the art,…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-10-12 Michael Benington , Leo Phan , Chris Pierre Paul , Evan Shoemaker , Priyanka Ranade , Torstein Collett , Grant Hodgson Perez , Christopher Krieger

Large Language Models (LLMs) continue to demonstrate superior performance with increasing scale, yet training models with billions to trillions of parameters requires staggering computational resources, e.g. a one-trillion-parameter…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-11 Ajay Navilarekal Rajgopal , Nikolai Solmsdorf

LLMs are typically trained in high-resource languages, and tasks in lower-resourced languages tend to underperform the higher-resource language counterparts for in-context learning. Despite the large body of work on prompting settings, it…

Computation and Language · Computer Science 2025-06-25 Christopher Toukmaji , Jeffrey Flanigan

Training large language models (LLMs) is known to be challenging because of the huge computational and memory capacity requirements. To address these issues, it is common to use a cluster of GPUs with 3D parallelism, which splits a model…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-05-29 Jinkyu Yim , Jaeyong Song , Yerim Choi , Jaebeen Lee , Jaewon Jung , Hongsun Jang , Jinho Lee

Large language models (LLMs), especially generative pre-trained transformers (GPTs), have recently demonstrated outstanding ability in information comprehension and problem-solving. This has motivated many studies in applying LLMs to…

Machine Learning · Computer Science 2024-05-21 Han Zhang , Akram Bin Sediq , Ali Afana , Melike Erol-Kantarci

The meanings of words and phrases depend not only on where they are used (contexts) but also on who use them (writers). Pretrained language models (PLMs) are powerful tools for capturing context, but they are typically pretrained and…

Computation and Language · Computer Science 2023-09-15 Daisuke Oba , Naoki Yoshinaga , Masashi Toyoda

Large language models are deep learning models with a large number of parameters. The models made noticeable progress on a large number of tasks, and as a consequence allowing them to serve as valuable and versatile tools for a diverse…

Software Engineering · Computer Science 2023-04-11 Maxim Vidgof , Stefan Bachhofner , Jan Mendling

When adapting large language models (LLMs) to a specific downstream task, two primary approaches are commonly employed: (1) prompt engineering, often with in-context few-shot learning, leveraging the model's inherent generalization…

Machine Learning · Computer Science 2025-12-24 Jorg Bornschein , Clare Lyle , Yazhe Li , Amal Rannen-Triki , Xu Owen He , Razvan Pascanu

With the wide adoption of language models for IR -- and specifically RAG systems -- the latency of the underlying LLM becomes a crucial bottleneck, since the long contexts of retrieved passages lead large prompts and therefore, compute…

Information Retrieval · Computer Science 2026-04-06 Cornelius Kummer , Lena Jurkschat , Michael Färber , Sahar Vahdati

Widely used language models (LMs) are typically built by scaling up a two-stage training pipeline: a pre-training stage that uses a very large, diverse dataset of text and a fine-tuning (sometimes, 'alignment') stage that uses targeted…

Computation and Language · Computer Science 2023-10-20 Eric Mitchell , Rafael Rafailov , Archit Sharma , Chelsea Finn , Christopher D. Manning

Chemical Language Models (CLMs) pre-trained on large scale molecular data are widely used for molecular property prediction. However, the common belief that increasing training resources such as model size, dataset size, and training…

Machine Learning · Computer Science 2026-05-14 Tatsuya Sagawa , Ryosuke Kojima

The potential of large language models (LLMs) to mitigate the time- and cost- related challenges associated with inductive thematic analysis (ITA) has been extensively explored in the literature. However, the use of LLMs to support ITA has…

Human-Computer Interaction · Computer Science 2025-04-01 Muhammad Talal Khalid , Ann-Perry Witmer

Large Language Models are expressive tools that enable complex tasks of text understanding within Computational Social Science. Their versatility, while beneficial, poses a barrier for establishing standardized best practices within the…

Computers and Society · Computer Science 2024-08-05 Anders Giovanni Møller , Luca Maria Aiello

Abbreviation expansion is a strategy used to speed up communication by limiting the amount of typing and using a language model to suggest expansions. Here we look at personalizing a Large Language Model's (LLM) suggestions based on prior…

Computation and Language · Computer Science 2023-12-25 Katrin Tomanek , Shanqing Cai , Subhashini Venugopalan

Scaling language models with more data, compute and parameters has driven significant progress in natural language processing. For example, thanks to scaling, GPT-3 was able to achieve strong results on in-context learning tasks. However,…

Using Large Language Models (LLMs) for Process Mining (PM) tasks is becoming increasingly essential, and initial approaches yield promising results. However, little attention has been given to developing strategies for evaluating and…

Databases · Computer Science 2024-07-01 Alessandro Berti , Humam Kourani , Hannes Hafke , Chiao-Yun Li , Daniel Schuster

We propose a new finetuning method to provide pre-trained large language models (LMs) the ability to scale test-time compute through the diffusion framework. By increasing the number of diffusion steps, we show our finetuned models achieve…

Computation and Language · Computer Science 2025-06-04 Edoardo Cetin , Tianyu Zhao , Yujin Tang

Large language models (LLMs) have shown remarkable capabilities in language understanding and generation. However, such impressive capability typically comes with a substantial model size, which presents significant challenges in deployment…

Computation and Language · Computer Science 2025-06-26 Guinan Su , Li Shen , Lu Yin , Shiwei Liu , Yanwu Yang , Jonas Geiping

Autonomous tuning of particle accelerators is an active and challenging field of research with the goal of enabling novel accelerator technologies cutting-edge high-impact applications, such as physics discovery, cancer research and…

Computation and Language · Computer Science 2024-05-16 Jan Kaiser , Annika Eichler , Anne Lauscher