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Many biochemical applications such as molecular property prediction require models to generalize beyond their training domains (environments). Moreover, natural environments in these tasks are structured, defined by complex descriptors such…

Machine Learning · Computer Science 2020-10-08 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Domain generalization in medical image classification is an important problem for trustworthy machine learning to be deployed in healthcare. We find that existing approaches for domain generalization which utilize ground-truth abnormality…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Jupinder Parmar , Khaled Saab , Brian Pogatchnik , Daniel Rubin , Christopher Ré

Domain generalization (DG) is about training models that generalize well under domain shift. Previous research on DG has been conducted mostly in single-source or multi-source settings. In this paper, we consider a third, lesser-known…

Machine Learning · Computer Science 2024-06-13 Han Gao , Kaican Li , Weiyan Xie , Zhi Lin , Yongxiang Huang , Luning Wang , Caleb Chen Cao , Nevin L. Zhang

Estimation of density functions supported on general domains arises when the data is naturally restricted to a proper subset of the real space. This problem is complicated by typically intractable normalizing constants. Score matching…

Methodology · Statistics 2020-09-25 Shiqing Yu , Mathias Drton , Ali Shojaie

Recent domain generalization (DG) approaches typically use the hypothesis learned on source domains for inference on the unseen target domain. However, such a hypothesis can be arbitrarily far from the optimal one for the target domain,…

Machine Learning · Computer Science 2023-05-25 Yi-Fan Zhang , Jindong Wang , Jian Liang , Zhang Zhang , Baosheng Yu , Liang Wang , Dacheng Tao , Xing Xie

Traditional domain generalization methods often rely on domain alignment to reduce inter-domain distribution differences and learn domain-invariant representations. However, domain shifts are inherently difficult to eliminate, which limits…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Yuheng Xu , Taiping Zhang

Domain generalization (DG) aims to tackle the distribution shift between training domains and unknown target domains. Generating new domains is one of the most effective approaches, yet its performance gain depends on the distribution…

Machine Learning · Computer Science 2023-05-17 Rui Dai , Yonggang Zhang , Zhen Fang , Bo Han , Xinmei Tian

As deep learning-based systems have become an integral part of everyday life, limitations in their generalization ability have begun to emerge. Machine learning algorithms typically rely on the i.i.d. assumption, meaning that their training…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Aristotelis Ballas , Christos Diou

Domain Generalization (DG) aims to develop classifiers that can generalize to new, unseen data distributions, a critical capability when collecting new domain-specific data is impractical. A common DG baseline minimizes the empirical risk…

Machine Learning · Computer Science 2024-12-11 Piotr Teterwak , Kuniaki Saito , Theodoros Tsiligkaridis , Kate Saenko , Bryan A. Plummer

Geographic distribution shift arises when the distribution of locations on Earth in a training dataset is different from what is seen at inference time. Using standard empirical risk minimization (ERM) in this setting can lead to uneven…

Machine Learning · Computer Science 2026-02-10 Ruth Crasto , Esther Rolf

Domain generalization (DG) focuses on transferring domain-invariant knowledge from multiple source domains (available at train time) to an, a priori, unseen target domain(s). This requires a class to be expressed in multiple domains for the…

Machine Learning · Computer Science 2023-06-02 Kimathi Kaai , Saad Hossain , Sirisha Rambhatla

Despite the rapid development of machine learning algorithms for domain generalization (DG), there is no clear empirical evidence that the existing DG algorithms outperform the classic empirical risk minimization (ERM) across standard…

Machine Learning · Computer Science 2024-03-19 Rui Qiao , Bryan Kian Hsiang Low

Domain generalization (DG) strives to address distribution shifts across diverse environments to enhance model's generalizability. Current DG approaches are confined to acquiring robust representations with continuous features, specifically…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Shaocong Long , Qianyu Zhou , Xikun Jiang , Chenhao Ying , Lizhuang Ma , Yuan Luo

In this study, we address the gradient-based domain generalization problem, where predictors aim for consistent gradient directions across different domains. Existing methods have two main challenges. First, minimization of gradient…

Machine Learning · Computer Science 2025-07-22 Khoi Do , Duong Nguyen , Nam-Khanh Le , Quoc-Viet Pham , Binh-Son Hua , Won-Joo Hwang

Researchers have been facing a difficult problem that data generation mechanisms could be influenced by internal or external factors leading to the training and test data with quite different distributions, consequently traditional…

Machine Learning · Statistics 2021-10-14 Anqi Wu

Domain Generalization (DG) research has gained considerable traction as of late, since the ability to generalize to unseen data distributions is a requirement that eludes even state-of-the-art training algorithms. In this paper we observe…

Machine Learning · Computer Science 2025-07-22 Aristotelis Ballas , Christos Diou

Learning guarantees often rely on assumptions of i.i.d. data, which will likely be violated in practice once predictors are deployed to perform real-world tasks. Domain adaptation approaches thus appeared as a useful framework yielding…

Machine Learning · Computer Science 2021-06-29 Joao Monteiro , Xavier Gibert , Jianqiao Feng , Vincent Dumoulin , Dar-Shyang Lee

Machine learning models often generalize poorly to out-of-distribution (OOD) data as a result of relying on features that are spuriously correlated with the label during training. Recently, the technique of Invariant Risk Minimization (IRM)…

Machine Learning · Computer Science 2023-01-18 Dongsung Huh , Avinash Baidya

We investigate the power of censoring techniques, first developed for learning {\em fair representations}, to address domain generalization. We examine {\em adversarial} censoring techniques for learning invariant representations from…

Machine Learning · Computer Science 2020-06-23 Zhun Deng , Frances Ding , Cynthia Dwork , Rachel Hong , Giovanni Parmigiani , Prasad Patil , Pragya Sur

Domain Randomization (DR) is known to require a significant amount of training data for good performance. We argue that this is due to DR's strategy of random data generation using a uniform distribution over simulation parameters, as a…

Computer Vision and Pattern Recognition · Computer Science 2021-08-31 Rawal Khirodkar , Kris M. Kitani