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This paper proposes a method for semiparametric regression analysis of large-scale data which are distributed over multiple hosts. This enables modeling of nonlinear relationships and both the batch approach, where analysis starts after all…
Data sparsity is a key challenge limiting the power of AI tools across various domains. The problem is especially pronounced in domains that require active user input rather than measurements derived from automated sensors. It is a critical…
Estimating the marginal and joint densities of the long-term average intakes of different dietary components is an important problem in nutritional epidemiology. Since these variables cannot be directly measured, data are usually collected…
Wearable devices permit the continuous monitoring of biological processes, such as blood glucose metabolism, and behavior, such as sleep quality and physical activity. The continuous monitoring often occurs in epochs of 60 seconds over…
The US Census Bureau will deliberately corrupt data sets derived from the 2020 US Census, enhancing the privacy of respondents while potentially reducing the precision of economic analysis. To investigate whether this trade-off is…
Nonparametric methods have been very popular in the last couple of decades in time series and regression, but no such development has taken place for spatial models. A rather obvious reason for this is the curse of dimensionality. For…
Electronic health records (EHR) are characterized as non-stationary, heterogeneous, noisy, and sparse data; therefore, it is challenging to learn the regularities or patterns inherent within them. In particular, sparseness caused mostly by…
As we gain access to a greater depth and range of health-related information about individuals, three questions arise: (1) Can we build better models to predict individual-level risk of ill health? (2) How much data do we need to…
Single subject prediction of brain disorders from neuroimaging data has gained increasing attention in recent years. Yet, for some heterogeneous disorders such as major depression disorder (MDD) and autism spectrum disorder (ASD), the…
Detection limit (DL) has become an increasingly ubiquitous issue in statistical analyses of biomedical studies, such as cytokine, metabolite and protein analysis. In regression analysis, if an explanatory variable is left-censored due to…
While non-parametric models, such as neural networks, are sufficient in the load forecasting, separate estimates of fixed and shiftable loads are beneficial to a wide range of applications such as distribution system operational planning,…
Analysis of survival data with biased samples caused by left-truncation or length-biased sampling has received extensive interest. Many inference methods have been developed for various survival models. These methods, however, break down…
Traditionally, the regime of mental healthcare has followed an episodic psychotherapy model wherein patients seek care from a provider through a prescribed treatment plan developed over multiple provider visits. Recent advances in wearable…
Nonparametric two-sample testing is a classical problem in inferential statistics. While modern two-sample tests, such as the edge count test and its variants, can handle multivariate and non-Euclidean data, contemporary gargantuan datasets…
In many longitudinal settings, time-varying covariates may not be measured at the same time as responses and are often prone to measurement error. Naive last-observation-carried-forward methods incur estimation biases, and existing…
Assessment of multistate disease progression is commonplace in biomedical research, such as, in periodontal disease (PD). However, the presence of multistate current status endpoints, where only a single snapshot of each subject's…
Measurement error arises commonly in clinical research settings that rely on data from electronic health records or large observational cohorts. In particular, self-reported outcomes are typical in cohort studies for chronic diseases such…
We introduce phase-diagram analysis, a standard tool in compressed sensing, to the X-ray CT community as a systematic method for determining how few projections suffice for accurate sparsity-regularized reconstruction. In compressed sensing…
When treating depression, clinicians are interested in determining the optimal treatment for a given patient, which is challenging given the amount of treatments available. To advance individualized treatment allocation, integrating data…
Mobile technology (e.g., mobile phones and wearable devices) provides scalable methods for collecting physiological and behavioral biomarkers in patients' naturalistic settings, as well as opportunities for therapeutic advancements and…