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Learning representation from unlabeled time series data is a challenging problem. Most existing self-supervised and unsupervised approaches in the time-series domain do not capture low and high-frequency features at the same time. Further,…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Vandan Gorade , Azad Singh , Deepak Mishra

Live-cell imaging of multiple subcellular structures is essential for understanding subcellular dynamics. However, the conventional multi-color sequential fluorescence microscopy suffers from significant imaging delays and limited number of…

Subcellular Processes · Quantitative Biology 2025-01-13 Mingyang Chen , Luhong Jin , Xuwei Xuan , Defu Yang , Yun Cheng , Ju Zhang

Many modern time-series datasets contain large numbers of output response variables sampled for prolonged periods of time. For example, in neuroscience, the activities of 100s-1000's of neurons are recorded during behaviors and in response…

Machine Learning · Computer Science 2022-03-15 Rui Meng , Kristofer Bouchard

Modern text-to-image generation models produce high-quality images that are both photorealistic and faithful to the text prompts. However, this quality comes at significant computational cost: nearly all of these models are iterative and…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Sadeep Jayasumana , Daniel Glasner , Srikumar Ramalingam , Andreas Veit , Ayan Chakrabarti , Sanjiv Kumar

In life sciences, fluorescent labeling techniques are used to study molecular structures and interactions of cells. However, this type of cell imaging has its own limitations, one of which is that the process of staining the cells could be…

Image and Video Processing · Electrical Eng. & Systems 2020-05-07 Eunjae Kim

Fluorescence lifetime imaging microscopy (FLIM) provides detailed information about molecular interactions and biological processes. A major bottleneck for FLIM is image resolution at high acquisition speeds, due to the engineering and…

Image and Video Processing · Electrical Eng. & Systems 2024-04-23 Valentin Kapitány , Areeba Fatima , Vytautas Zickus , Jamie Whitelaw , Ewan McGhee , Robert Insall , Laura Machesky , Daniele Faccio

Multi-photon microscopy has played a significant role in biological imaging since it allows to observe living tissues with improved penetration depth and excellent sectioning effect. Multi-photon microscopy relies on multi-photon…

Quantitative analysis of the dynamics of tiny cellular and sub-cellular structures, known as particles, in time-lapse cell microscopy sequences requires the development of a reliable multi-target tracking method capable of tracking numerous…

Computer Vision and Pattern Recognition · Computer Science 2015-07-24 Seyed Hamid Rezatofighi , Stephen Gould , Ba Tuong Vo , Ba-Ngu Vo , Katarina Mele , Richard Hartley

Traditional methods for biological shape inference, such as deep learning (DL) and active contour models, face important limitations in 3D. DL approaches require large annotated datasets, which are often impractical to obtain, while active…

Biological Physics · Physics 2025-08-04 Sacha Ichbiah , Anshuman Sinha , Fabrice Delbary , Hervé Turlier

Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique in biomedical research that uses the fluorophore decay rate to provide additional contrast in fluorescence microscopy. However, at present, the calculation, analysis,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Cara Ravasio , Scott S. Howard

The ability to automatically estimate the quality and coverage of the samples produced by a generative model is a vital requirement for driving algorithm research. We present an evaluation metric that can separately and reliably measure…

Machine Learning · Statistics 2019-10-31 Tuomas Kynkäänniemi , Tero Karras , Samuli Laine , Jaakko Lehtinen , Timo Aila

Multiscale models provide a unique tool for studying complex processes that study events occurring at different scales across space and time. In the context of biological systems, such models can simulate mechanisms happening at the…

Quantitative Methods · Quantitative Biology 2024-06-27 Marco Ruscone , Andrea Checcoli , Randy Heiland , Emmanuel Barillot , Paul Macklin , Laurence Calzone , Vincent Noël

We present novel approaches involving generative adversarial networks and diffusion models in order to synthesize high quality, live and spoof fingerprint images while preserving features such as uniqueness and diversity. We generate live…

Computer Vision and Pattern Recognition · Computer Science 2024-03-22 W. Tang , D. Figueroa , D. Liu , K. Johnsson , A. Sopasakis

We report, for the first time, a multi-confocal Fluorescence Correlation Spectroscopy (mFCS) technique which allows parallel measurements at different locations, by combining a Spatial Light Modulator (SLM), with an Electron Multiplying-CCD…

Labelling data is expensive and time consuming especially for domains such as medical imaging that contain volumetric imaging data and require expert knowledge. Exploiting a larger pool of labeled data available across multiple centers,…

Computer Vision and Pattern Recognition · Computer Science 2020-09-03 Daiqing Li , Amlan Kar , Nishant Ravikumar , Alejandro F Frangi , Sanja Fidler

The human microbiome is a complex ecological system, and describing its structure and function under different environmental conditions is important from both basic scientific and medical perspectives. Viewed through a biostatistical lens,…

Applications · Statistics 2017-11-17 Kris Sankaran , Susan P. Holmes

Time series analysis is crucial for understanding dynamics of complex systems. Recent advances in foundation models have led to task-agnostic Time Series Foundation Models (TSFMs) and Large Language Model-based Time Series Models (TSLLMs),…

Machine Learning · Computer Science 2025-03-17 Xu Liu , Taha Aksu , Juncheng Liu , Qingsong Wen , Yuxuan Liang , Caiming Xiong , Silvio Savarese , Doyen Sahoo , Junnan Li , Chenghao Liu

We present a method for generating alpha mattes using a limited data source. We pretrain a novel transformerbased model (StyleMatte) on portrait datasets. We utilize this model to provide image-mask pairs for the StyleGAN3-based network…

Computer Vision and Pattern Recognition · Computer Science 2023-05-24 Sergej Chicherin , Karen Efremyan

StyleGAN is a state-of-art generative adversarial network architecture that generates random 2D high-quality synthetic facial data samples. In this paper, we recap the StyleGAN architecture and training methodology and present our…

Neural and Evolutionary Computing · Computer Science 2020-03-25 Viktor Varkarakis , Shabab Bazrafkan , Peter Corcoran

Fluorescence microscopy is a widely used method among cell biologists for studying the localization and co-localization of fluorescent protein. For microbial cell biologists, these studies often include tedious and time-consuming manual…

Computer Vision and Pattern Recognition · Computer Science 2020-09-29 Jonathan Reiner , Guy Azran , Gal Hyams