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We introduce a parallel algorithmic architecture for metagenomic sequence assembly, termed MetaPar, which allows for significant reductions in assembly time and consequently enables the processing of large genomic datasets on computers with…

Quantitative Methods · Quantitative Biology 2013-11-18 Minji Kim , Jonathan G. Ligo , Amin Emad , Farzad Farnoud , Olgica Milenkovic , Venugopal V. Veeravalli

Metagenomic studies have increasingly utilized sequencing technologies in order to analyze DNA fragments found in environmental samples.One important step in this analysis is the taxonomic classification of the DNA fragments. Conventional…

Genomics · Quantitative Biology 2020-02-11 Andreas Georgiou , Vincent Fortuin , Harun Mustafa , Gunnar Rätsch

Metagenomics has led to significant advancements in many fields. Metagenomic analysis commonly involves the key tasks of determining the species present in a sample and their relative abundances. These tasks require searching large…

At the last step of short read mapping, the candidate locations of the reads on the reference genome are verified to compute their differences from the corresponding reference segments using sequence alignment algorithms. Calculating the…

Genomics · Quantitative Biology 2024-07-04 Zülal Bingöl , Mohammed Alser , Onur Mutlu , Ozcan Ozturk , Can Alkan

Metagenomics is an emerging field of molecular biology concerned with analyzing the genomes of environmental samples comprising many different diverse organisms. Given the nature of metagenomic data, one usually has to sequence the genomic…

Genomics · Quantitative Biology 2013-11-20 Jonathan G. Ligo , Minji Kim , Amin Emad , Olgica Milenkovic , Venugopal V. Veeravalli

Genomic and metagenomic fields, generating huge sets of short genomic sequences, brought their own share of high performance problems. To extract relevant pieces of information from the huge data sets generated by current sequencing…

Data Structures and Algorithms · Computer Science 2016-05-27 Camille Marchet , Antoine Limasset , Lucie Bittner , Pierre Peterlongo

Minimizing data storage poses a significant challenge in large-scale metagenomic projects. In this paper, we present a new method for improving the encoding of FASTQ files generated by metagenomic sequencing. This method incorporates…

Information Theory · Computer Science 2024-01-04 Diogo Pratas , Armando J. Pinho

Metagenomics characterizes the taxonomic diversity of microbial communities by sequencing DNA directly from an environmental sample. One of the main challenges in metagenomics data analysis is the binning step, where each sequenced read is…

Quantitative Methods · Quantitative Biology 2015-05-27 Kévin Vervier , Pierre Mahé , Maud Tournoud , Jean-Baptiste Veyrieras , Jean-Philippe Vert

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

Motivation: Accurate data analysis and quality control is critical for metagenomic studies. Though many tools exist to analyze metagenomic data there is no consistent framework to integrate and run these tools across projects. Currently,…

Quantitative Methods · Quantitative Biology 2020-09-28 David C Danko , Chris Mason

Metagenomics has led to significant advances in many fields. Metagenomic analysis commonly involves the key tasks of determining the species present in a sample and their relative abundances. These tasks require searching large metagenomic…

Over the years, many different indexing techniques and search algorithms have been proposed, including CSS-trees, CSB+ trees, k-ary binary search, and fast architecture sensitive tree search. There have also been papers on how best to set…

Databases · Computer Science 2017-06-22 Florian Gross

The ability to quickly and accurately identify microbial species in a sample, known as metagenomic profiling, is critical across various fields, from healthcare to environmental science. This paper introduces a novel method to profile…

Genomics · Quantitative Biology 2025-04-10 Riselda Kodra , Hadjer Benmeziane , Irem Boybat , William Andrew Simon

Motivation: Read mapping is a computationally expensive process and a major bottleneck in genomics analyses. The performance of read mapping is mainly limited by the performance of three key computational steps: Index Querying, Seed…

Hardware Architecture · Computer Science 2023-10-02 Julien Eudine , Mohammed Alser , Gagandeep Singh , Can Alkan , Onur Mutlu

Traditionally, we usually utilize the method of shotgun to cut a DNA sequence into pieces and we have to reconstruct the original DNA sequence from the pieces, those are widely used method for DNA assembly. Emerging DNA sequence…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-04-15 Yukun Zhong , ZhiWei He , XianHong Wang , XiongBin Cao

Read mapping is a fundamental, yet computationally-expensive step in many genomics applications. It is used to identify potential matches and differences between fragments (called reads) of a sequenced genome and an already known genome…

A basic problem in metagenomics is to assign a sequenced read to the correct species in the reference collection. In typical applications in genomic epidemiology and viral metagenomics the reference collection consists of set of species…

Data Structures and Algorithms · Computer Science 2020-06-11 Dustin Cobas , Veli Mäkinen , Massimiliano Rossi

Deep learning compiler frameworks are gaining ground as a more portable back-end for deep learning applications on increasingly diverse hardware. However, they face the daunting challenge of matching performance offered by hand-tuned…

Machine Learning · Computer Science 2021-02-10 Jaehun Ryu , Hyojin Sung

The marine environment is one of the most important sources for microbial biodiversity on the planet. These microbes are drivers for many biogeochemical processes, and their enormous genetic potential is still not fully explored or…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-04-15 Espen Mikal Robertsen , Tim Kahlke , Inge Alexander Raknes , Edvard Pedersen , Erik Kjærner Semb , Martin Ernstsen , Lars Ailo Bongo , Nils Peder Willassen

Motivation: High throughput DNA sequencing (HTS) technologies generate an excessive number of small DNA segments -- called short reads -- that cause significant computational burden. To analyze the entire genome, each of the billions of…

Genomics · Quantitative Biology 2020-09-29 Mohammed Alser , Hasan Hassan , Hongyi Xin , Oğuz Ergin , Onur Mutlu , Can Alkan
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