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Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

Electronic health records (EHRs) are longitudinal records of a patient's interactions with healthcare systems. A patient's EHR data is organized as a three-level hierarchy from top to bottom: patient journey - all the experiences of…

Machine Learning · Computer Science 2020-09-29 Xueping Peng , Guodong Long , Tao Shen , Sen Wang , Jing Jiang , Chengqi Zhang

The pivotal shift from traditional paper-based records to sophisticated Electronic Health Records (EHR), enabled systematic collection and analysis of patient data through descriptive statistics, providing insight into patterns and trends…

Artificial Intelligence · Computer Science 2025-02-18 Muhammet Alkan , Hester Huijsdens , Yola Jones , Fani Deligianni

Risk prediction is central to both clinical medicine and public health. While many machine learning models have been developed to predict mortality, they are rarely applied in the clinical literature, where classification tasks typically…

Machine Learning · Statistics 2017-12-05 Maggie Makar , Marzyeh Ghassemi , David Cutler , Ziad Obermeyer

This paper reports our preliminary work on medical incident prediction in general, and fall risk prediction in specific, using machine learning. Data for the machine learning are generated only from the particular subset of the electronic…

Machine Learning · Computer Science 2021-09-16 Atsushi Yanagisawa , Chintaka Premachandra , Hiruharu Kawanaka , Atsushi Inoue , Takeo Hata , Eiichiro Ueda

Many diagnostic errors occur because clinicians cannot easily access relevant information in patient Electronic Health Records (EHRs). In this work we propose a method to use LLMs to identify pieces of evidence in patient EHR data that…

Hypertension is a major risk factor for stroke, cardiovascular disease, and end-stage renal disease, and its prevalence is expected to rise dramatically. Effective hypertension management is thus critical. A particular priority is…

Computers and Society · Computer Science 2019-07-02 Ramin Mohammadi , Sarthak Jain , Stephen Agboola , Ramya Palacholla , Sagar Kamarthi , Byron C. Wallace

Electronic Health Records (EHRs) are commonly used by the machine learning community for research on problems specifically related to health care and medicine. EHRs have the advantages that they can be easily distributed and contain many…

Machine Learning · Computer Science 2020-06-08 Kieran Chin-Cheong , Thomas Sutter , Julia E. Vogt

Understanding deep learning model behavior is critical to accepting machine learning-based decision support systems in the medical community. Previous research has shown that jointly using clinical notes with electronic health record (EHR)…

Machine Learning · Computer Science 2022-12-07 Severin Husmann , Hugo Yèche , Gunnar Rätsch , Rita Kuznetsova

Data poisoning attacks aim to manipulate the model produced by a learning algorithm by adversarially modifying the training set. We consider differential privacy as a defensive measure against this type of attack. We show that such learners…

Machine Learning · Computer Science 2019-07-08 Yuzhe Ma , Xiaojin Zhu , Justin Hsu

With the broad application of deep neural networks (DNNs), backdoor attacks have gradually attracted attention. Backdoor attacks are insidious, and poisoned models perform well on benign samples and are only triggered when given specific…

Machine Learning · Computer Science 2022-07-12 Chang Yue , Peizhuo Lv , Ruigang Liang , Kai Chen

Genomic foundation models trained on DNA sequences have demonstrated remarkable capabilities across diverse biological tasks, from variant effect prediction to genome design. These models are typically trained on massive, publicly sourced…

Genomics · Quantitative Biology 2026-03-31 Charalampos Koilakos , Ioannis Mouratidis , Ilias Georgakopoulos-Soares

Healthcare AI systems face major vulnerabilities to data poisoning that current defenses and regulations cannot adequately address. We analyzed eight attack scenarios in four categories: architectural attacks on convolutional neural…

Cryptography and Security · Computer Science 2026-01-26 Farhad Abtahi , Fernando Seoane , Iván Pau , Mario Vega-Barbas

Backdoor attacks are an insidious security threat against machine learning models. Adversaries can manipulate the predictions of compromised models by inserting triggers into the training phase. Various backdoor attacks have been devised…

Computation and Language · Computer Science 2023-05-29 Xuanli He , Jun Wang , Benjamin Rubinstein , Trevor Cohn

This paper investigates the critical issue of data poisoning attacks on AI models, a growing concern in the ever-evolving landscape of artificial intelligence and cybersecurity. As advanced technology systems become increasingly prevalent…

Cryptography and Security · Computer Science 2025-03-13 Halima I. Kure , Pradipta Sarkar , Ahmed B. Ndanusa , Augustine O. Nwajana

Generating synthetic Electronic Health Records (EHRs) offers significant potential for data augmentation, privacy-preserving data sharing, and improving machine learning model training. We propose a novel tokenization strategy tailored for…

Machine Learning · Computer Science 2024-11-21 Hojjat Karami , David Atienza , Anisoara Ionescu

In this work, we investigate the concept of biometric backdoors: a template poisoning attack on biometric systems that allows adversaries to stealthily and effortlessly impersonate users in the long-term by exploiting the template update…

Cryptography and Security · Computer Science 2020-11-06 Giulio Lovisotto , Simon Eberz , Ivan Martinovic

Deep neural networks (DNNs) are vulnerable to backdoor attack, which does not affect the network's performance on clean data but would manipulate the network behavior once a trigger pattern is added. Existing defense methods have greatly…

Machine Learning · Computer Science 2025-04-08 Min Liu , Alberto Sangiovanni-Vincentelli , Xiangyu Yue

Data poisoning causes misclassification of test time target examples by injecting maliciously crafted samples in the training data. Existing defenses are often effective only against a specific type of targeted attack, significantly degrade…

Machine Learning · Computer Science 2022-10-19 Yu Yang , Tian Yu Liu , Baharan Mirzasoleiman

The performance of a machine learning-based malware classifier depends on the large and updated training set used to induce its model. In order to maintain an up-to-date training set, there is a need to continuously collect benign and…

Cryptography and Security · Computer Science 2020-11-02 Tzvika Shapira , David Berend , Ishai Rosenberg , Yang Liu , Asaf Shabtai , Yuval Elovici