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The prediction of physicochemical properties from molecular structures is a crucial task for artificial intelligence aided molecular design. A growing number of Graph Neural Networks (GNNs) have been proposed to address this challenge.…

Machine Learning · Computer Science 2020-11-17 Shuo Zhang , Yang Liu , Lei Xie

Due to the wide range of timescales that are present in macromolecular systems, hierarchical multiscale strategies are necessary for their computational study. Coarse-graining (CG) allows to establish a link between different system…

Nuclear materials are often demanded to function for extended time in extreme environments, including high radiation fluxes and transmutation, high temperature and temperature gradients, stresses, and corrosive coolants. They also have a…

Materials Science · Physics 2022-11-18 Dane Morgan , Ghanshyam Pilania , Adrien Couet , Blas P. Uberuaga , Cheng Sun , Ju Li

In ultracold-atom experiments, data often comes in the form of images which suffer information loss inherent in the techniques used to prepare and measure the system. This is particularly problematic when the processes of interest are…

Quantum Gases · Physics 2022-06-03 Shangjie Guo , Sophia M. Koh , Amilson R. Fritsch , I. B. Spielman , Justyna P. Zwolak

Understanding and predicting polymer solubility in various solvents is critical for applications ranging from recycling to pharmaceutical formulation. This work presents a deep learning framework that predicts polymer solubility, expressed…

Machine Learning · Computer Science 2025-12-11 Andrew Reinhard

Modern deep learning models excel at pattern recognition but remain fundamentally limited by their reliance on spurious correlations, leading to poor generalization and a demand for massive datasets. We argue that a key ingredient for…

Machine Learning · Computer Science 2025-09-17 Mohamed Zayaan S

Deep learning based methods have been widely applied to predict various kinds of molecular properties in the pharmaceutical industry with increasingly more success. Solvation free energy is an important index in the field of organic…

Chemical Physics · Physics 2021-05-06 Ramin Ansari , Amirata Ghorbani

Molecular representation is a critical element in our understanding of the physical world and the foundation for modern molecular machine learning. Previous molecular machine learning models have employed strings, fingerprints, global…

Machine Learning · Computer Science 2025-05-28 Daniil A. Boiko , Thiago Reschützegger , Benjamin Sanchez-Lengeling , Samuel M. Blau , Gabe Gomes

Molecular Dynamics (MD) simulation is a powerful tool for understanding the dynamics and structure of matter. Since the resolution of MD is atomic-scale, achieving long time-scale simulations with femtosecond integration is very expensive.…

Machine Learning · Computer Science 2022-04-27 Zijie Li , Kazem Meidani , Prakarsh Yadav , Amir Barati Farimani

Interpreting the impedance response of perovskite solar cells (PSCs) is challenging due to the complex coupling of ionic and electronic motion. While drift-diffusion (DD) modelling is a reliable method, its mathematical complexity makes…

Applied Physics · Physics 2026-02-03 Mahmoud Nabil , Isel Grau-García , Ricardo Grau-Crespo , Said Hamad , Juan A. Anta

Machine learning (ML) is a promising approach for predicting small molecule properties in drug discovery. Here, we provide a comprehensive overview of various ML methods introduced for this purpose in recent years. We review a wide range of…

Biomolecules · Quantitative Biology 2023-08-25 Nikolai Schapin , Maciej Majewski , Alejandro Varela , Carlos Arroniz , Gianni De Fabritiis

As machine learning techniques are applied to a widening range of applications, high throughput machine learning (ML) inference servers have become critical for online service applications. Such ML inference servers pose two challenges:…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-06 Seungbeom Choi , Sunho Lee , Yeonjae Kim , Jongse Park , Youngjin Kwon , Jaehyuk Huh

Machine learning has been increasingly applied in climate modeling on system emulation acceleration, data-driven parameter inference, forecasting, and knowledge discovery, addressing challenges such as physical consistency, multi-scale…

State-of-the-art deep learning models have been extensively utilized to reconstruct small-scale structures from coarse-grained data in turbulent flows. However, their application has predominantly been restricted to structured uniform…

Fluid Dynamics · Physics 2026-03-03 Priyabrat Dash , Konduri Aditya , Christos E. Frouzakis , Mathis Bode

Molecular dynamics (MD) has become a powerful tool for studying biophysical systems, due to increasing computational power and availability of software. Although MD has made many contributions to better understanding these complex…

Computational Physics · Physics 2019-09-27 Yihang Wang , Joao Marcelo Lamim Ribeiro , Pratyush Tiwary

Coarse-grained (CG) modeling simplifies molecular systems by mapping groups of atoms into representative units. However, traditional CG approaches rely on fixed mapping rules, which limit their ability to handle diverse chemical systems and…

Computational Physics · Physics 2025-09-26 Zhixuan Zhong , Linbo Ma , Jian Jiang

Machine learning (ML) can be used to construct surrogate models for the fast prediction of a property of interest. ML can thus be applied to chemical projects, where the usual experimentation or calculation techniques can take hours or days…

Simulating the dynamics of ions near polarizable nanoparticles (NPs) using coarse-grained models is extremely challenging due to the need to solve the Poisson equation at every simulation timestep. Recently, a molecular dynamics (MD) method…

Computational Physics · Physics 2019-11-01 JCS Kadupitiya , Geoffrey C. Fox , Vikram Jadhao

Sequence modelling approaches for epigenetic profile prediction have recently expanded in terms of sequence length, model size, and profile diversity. However, current models cannot infer on many experimentally feasible tissue and assay…

Genomics · Quantitative Biology 2023-08-24 Jacob Deasy , Ron Schwessinger , Ferran Gonzalez , Stephen Young , Kim Branson

Accurate and efficient climate simulations are crucial for understanding Earth's evolving climate. However, current general circulation models (GCMs) face challenges in capturing unresolved physical processes, such as cloud and convection.…

Atmospheric and Oceanic Physics · Physics 2026-01-27 Xin Wang , Jianda Chen , Juntao Yang , Jeff Adie , Simon See , Kalli Furtado , Chen Chen , Troy Arcomano , Romit Maulik , Wei Xue , Gianmarco Mengaldo
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