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Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

Neuroblastoma (NB), a leading cause of childhood cancer mortality, exhibits significant histopathological variability, necessitating precise subtyping for accurate prognosis and treatment. Traditional diagnostic methods rely on subjective…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Huangwei Chen , Yifei Chen , Zhenyu Yan , Mingyang Ding , Chenlei Li , Zhu Zhu , Feiwei Qin

We study multimodal survival analysis integrating clinical text, tabular covariates, and genomic profiles using locally deployable large language models (LLMs). As many institutions face tight computational and privacy constraints, this…

Machine Learning · Computer Science 2026-03-24 Moritz Gögl , Christopher Yau

Early detection of skin cancers like melanoma is crucial to ensure high chances of survival for patients. Clinical application of Deep Learning (DL)-based Decision Support Systems (DSS) for skin cancer screening has the potential to improve…

Computer Vision and Pattern Recognition · Computer Science 2021-03-10 Adriano Lucieri , Andreas Dengel , Sheraz Ahmed

Survival risk stratification is an important step in clinical decision making for breast cancer management. We propose a novel deep learning approach for this purpose by integrating histopathological imaging, genetic and clinical data. It…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Raktim Kumar Mondol , Ewan K. A. Millar , Arcot Sowmya , Erik Meijering

Due to its predominantly asymptomatic or mildly symptomatic progression, lung cancer is often diagnosed in advanced stages, resulting in poorer survival rates for patients. As with other cancers, early detection significantly improves the…

Cancer is the uncontrollable cell division of abnormal cells inside the human body, which can spread to other body organs. It is one of the non-communicable diseases (NCDs) and NCDs accounts for 71% of total deaths worldwide whereas lung…

Image and Video Processing · Electrical Eng. & Systems 2021-12-28 Neha Baranwal , Preethi Doravari , Renu Kachhoria

While deep learning methods are increasingly being applied to tasks such as computer-aided diagnosis, these models are difficult to interpret, do not incorporate prior domain knowledge, and are often considered as a "black-box." The lack of…

Computer Vision and Pattern Recognition · Computer Science 2018-06-05 Shiwen Shen , Simon X. Han , Denise R. Aberle , Alex A. T. Bui , Willliam Hsu

Machine learning models have utilized semantic features, deep features, or both to assess lung nodule malignancy. However, their reliance on manual annotation during inference, limited interpretability, and sensitivity to imaging variations…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Luoting Zhuang , Seyed Mohammad Hossein Tabatabaei , Ramin Salehi-Rad , Linh M. Tran , Denise R. Aberle , Ashley E. Prosper , William Hsu

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with early and accurate diagnosis playing a pivotal role in improving patient outcomes. Automated detection of pulmonary nodules in computed tomography…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Abhinav Roy , Bhavesh Gyanchandani , Aditya Oza

Nasopharyngeal Carcinoma (NPC) is a malignant epithelial cancer arising from the nasopharynx. Survival prediction is a major concern for NPC patients, as it provides early prognostic information to plan treatments. Recently, deep survival…

Image and Video Processing · Electrical Eng. & Systems 2022-09-20 Mingyuan Meng , Bingxin Gu , Lei Bi , Shaoli Song , David Dagan Feng , Jinman Kim

The introduction of lung cancer screening programs will produce an unprecedented amount of chest CT scans in the near future, which radiologists will have to read in order to decide on a patient follow-up strategy. According to the current…

Several deep learning algorithms have been developed to predict survival of cancer patients using whole slide images (WSIs).However, identification of image phenotypes within the WSIs that are relevant to patient survival and disease…

Image and Video Processing · Electrical Eng. & Systems 2022-11-30 Xingyu Li , Jitendra Jonnagaddala , Min Cen , Hong Zhang , Xu Steven Xu

As advancements in technology and medicine are being made, many countries are still unable to access quality medical care due to cost and lack of qualified medical personnel. This discrepancy in healthcare has caused many preventable…

Image and Video Processing · Electrical Eng. & Systems 2022-10-12 Kyler Larsen

Gene expression profiles obtained through DNA microarray have proven successful in providing critical information for cancer detection classifiers. However, the limited number of samples in these datasets poses a challenge to employ complex…

Machine Learning · Computer Science 2024-08-20 Arya Hadizadeh Moghaddam , Mohsen Nayebi Kerdabadi , Cuncong Zhong , Zijun Yao

Respiratory diseases remain major global health challenges, and traditional auscultation is often limited by subjectivity, environmental noise, and inter-clinician variability. This study presents an explainable multimodal deep learning…

Sound · Computer Science 2025-12-02 S M Asiful Islam Saky , Md Rashidul Islam , Md Saiful Arefin , Shahaba Alam

Accurate survival prediction is critical in oncology for prognosis and treatment planning. Traditional approaches often rely on a single data modality, limiting their ability to capture the complexity of tumor biology. To address this…

Machine Learning · Computer Science 2025-07-11 Alba Garrido , Alejandro Almodóvar , Patricia A. Apellániz , Juan Parras , Santiago Zazo

Objectives: Lung cancer poses a significant global health challenge, necessitating improved prognostic methods for personalized treatment. This study introduces a censor-aware semi-supervised learning (SSL) framework that integrates…

Medical Physics · Physics 2025-06-16 Arman Gorji , Ali Fathi Jouzdani , Nima Sanati , Ren Yuan , Arman Rahmim , Mohammad R. Salmanpour

Cardiovascular disease (CVD) is a leading cause of death in the lung cancer screening population. Chest CT scans made in lung cancer screening are suitable for identification of participants at risk of CVD. Existing methods analyzing CT…

Computer Vision and Pattern Recognition · Computer Science 2018-10-05 Sanne G. M. van Velzen , Majd Zreik , Nikolas Lessmann , Max A. Viergever , Pim A. de Jong , Helena M. Verkooijen , Ivana Išgum

Deep learning, as a promising new area of machine learning, has attracted a rapidly increasing attention in the field of medical imaging. Compared to the conventional machine learning methods, deep learning requires no hand-tuned feature…

Quantitative Methods · Quantitative Biology 2016-11-29 He Yang , Hengyong Yu , Ge Wang
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