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The dynamics of gene transcription is tightly regulated in eukaryotes. Recent experiments have revealed various kinds of transcriptional dynamics, such as RNA polymerase II pausing, that involves regulation at the transcription initiation…

Cell Behavior · Quantitative Biology 2015-08-11 Yucheng Hu , John Lowengrub

Replication and transcription are two important processes in living systems. To execute such processes, various proteins work far away from equilibrium in a staggered way. Motivated by this, aspects of hysteresis during unzipping of DNA…

Soft Condensed Matter · Physics 2013-03-14 Garima Mishra , Poulomi Sadhukhan , Somendra M Bhattacharjee , Sanjay Kumar

Time lags occur in a vast range of real-world dynamical systems due to finite reaction times or propagation speeds. Here we derive an analytical approach to determine the asymptotic stability of synchronous states in networks of coupled…

Dynamical Systems · Mathematics 2020-07-08 Reyk Börner , Paul Schultz , Benjamin Ünzelmann , Deli Wang , Frank Hellmann , Jürgen Kurths

Time delays pose an important challenge in networked control systems, which are now ubiquitous. Focusing on switched systems, we introduce a framework that provides an upper bound for errors caused by switching delays. Our framework is…

Systems and Control · Computer Science 2017-12-27 Kengo Kido , Sean Sedwards , Ichiro Hasuo

Abstract-In this manuscript, model predictive control for class of discrete fuzzy large-scale systems subjected to bounded time-varying delay and disturbances is studied. The considered method is Razumikhin for time-varying delay…

Systems and Control · Electrical Eng. & Systems 2021-08-26 Mohammad Sarbaz , Iman Zamani , Mohammad Manthouri , Asier Ibeas

This chapter presents a dynamical systems point of view of the study of systems with delays. The focus is on how advanced tools from bifurcation theory, as implemented for example in the package DDE-BIFTOOL, can be applied to the study of…

Dynamical Systems · Mathematics 2021-08-06 Bernd Krauskopf , Jan Sieber

Delay is an important and ubiquitous aspect of many biochemical processes. For example, delay plays a central role in the dynamics of genetic regulatory networks as it stems from the sequential assembly of first mRNA and then protein.…

Molecular Networks · Quantitative Biology 2015-06-18 Chinmaya Gupta , José Manuel López , Robert Azencott , Matthew R Bennett , Krešimir Josić , William Ott

The Frimmer-Novotny model to simulate two-level systems by coupled oscillators is extended by incorporating a constant time delay in the coupling. The effects of the introduced delay on system dynamics and two-level modeling are then…

Distributed systems in which concurrent proposals are mutually exclusive face a fundamental stability constraint under network delay. In open systems where global state progression is event-driven rather than round-driven, propagation delay…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-31 Bin Chen , Dechuang Huang

For a wide class of second order nonlinear non-autonomous models, we illustrate that combining proportional state control with the feedback that is proportional to the derivative of the chaotic signal, allows to stabilize unstable motions…

Dynamical Systems · Mathematics 2016-06-10 Leonid Berezansky , Elena Braverman , Lev Idels

Delayed feedback control is an easy realizable control method which generates control force by comparing the current and the delayed version of the system states. In this paper, a new form of the delayed feedback structure is introduced.…

Systems and Control · Computer Science 2019-02-08 Zahed Dastan , Mahsan Tavakoli-Kakhki

Delay coordinates are a widely used technique to pass from observations of a dynamical system to a representation of the dynamical system as an embedding in Euclidean space. Current proofs show that delay coordinates of a given dynamical…

Dynamical Systems · Mathematics 2018-06-21 Raymundo Navarrete , Divakar Viswanath

Significant variations of delays among connecting neurons cause an inevitable disadvantage of asynchronous brain dynamics compared to synchronous deep learning. However, this study demonstrates that this disadvantage can be converted into a…

Biological Physics · Physics 2024-10-16 Yuval Meir , Ofek Tevet , Yarden Tzach , Shiri Hodassman , Ido Kanter

Learning how complex dynamical systems evolve over time is a key challenge in system identification. For safety critical systems, it is often crucial that the learned model is guaranteed to converge to some equilibrium point. To this end,…

Machine Learning · Computer Science 2021-12-13 Andreas Schlaginhaufen , Philippe Wenk , Andreas Krause , Florian Dörfler

Frequency responses of multi-degree-of-freedom mechanical systems with weak forcing and damping can be studied as perturbations from their conservative limit. Specifically, recent results show how bifurcations near resonances can be…

Dynamical Systems · Mathematics 2020-11-11 Mattia Cenedese , George Haller

A variety of biomolecular systems rely on exploratory dynamics to reach target locations or states within a cell. Without a mechanism to remotely sense and move directly towards a target, the system must sample over many paths, often…

Biological Physics · Physics 2025-09-01 Elena F Koslover , Milo M Lin , Rob Phillips

We study the dynamics of a piecewise-linear second-order delay differential equation that is representative of feedback systems with relays (switches) that actuate after a fixed delay. The system under study exhibits strong…

Dynamical Systems · Mathematics 2023-06-13 Lucas Illing , Pierce Ryan , Andreas Amann

In systems of coupled oscillators, the effects of complex signaling can be captured by time delays and phase shifts. Here, we show how time delays and phase shifts lead to different oscillator dynamics and how synchronization rates can be…

Adaptation and Self-Organizing Systems · Physics 2018-03-30 David J. Jörg , Luis G. Morelli , Saúl Ares , Frank Jülicher

Biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adaptation kinetics, fold-change detection, entrainment, and…

Quantitative Methods · Quantitative Biology 2026-01-05 Eduardo D. Sontag

In this paper, we study both the oscillation and the stability of impulsive differential equations when not only the continuous argument but also the impulse condition involves delay. The results obtained in the present paper improve and…

Classical Analysis and ODEs · Mathematics 2010-07-12 Basak Karpuz