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The neural plausibility of backpropagation has long been disputed, primarily for its use of non-local weight transport $-$ the biologically dubious requirement that one neuron instantaneously measure the synaptic weights of another. Until…

Neurons and Cognition · Quantitative Biology 2020-06-26 Daniel Kunin , Aran Nayebi , Javier Sagastuy-Brena , Surya Ganguli , Jonathan M. Bloom , Daniel L. K. Yamins

The development of biologically-plausible learning algorithms is important for understanding learning in the brain, but most of them fail to scale-up to real-world tasks, limiting their potential as explanations for learning by real brains.…

Neural and Evolutionary Computing · Computer Science 2022-02-01 Maxence Ernoult , Fabrice Normandin , Abhinav Moudgil , Sean Spinney , Eugene Belilovsky , Irina Rish , Blake Richards , Yoshua Bengio

We consider artificial neurons which will update their weight coefficients with an internal rule based on backpropagation, rather than using it as an external training procedure. To achieve this we include the backpropagation error estimate…

Neural and Evolutionary Computing · Computer Science 2018-08-07 M. N. Nazarov

The Backpropagation algorithm relies on the abstraction of using a neural model that gets rid of the notion of time, since the input is mapped instantaneously to the output. In this paper, we claim that this abstraction of ignoring time,…

Machine Learning · Computer Science 2020-06-19 Alessandro Betti , Marco Gori

Current algorithms for deep learning probably cannot run in the brain because they rely on weight transport, where forward-path neurons transmit their synaptic weights to a feedback path, in a way that is likely impossible biologically. An…

Machine Learning · Computer Science 2020-01-13 Mohamed Akrout , Collin Wilson , Peter C. Humphreys , Timothy Lillicrap , Douglas Tweed

Hebbian plasticity is a powerful principle that allows biological brains to learn from their lifetime experience. By contrast, artificial neural networks trained with backpropagation generally have fixed connection weights that do not…

Neural and Evolutionary Computing · Computer Science 2016-10-20 Thomas Miconi

In both machine learning and in computational neuroscience, plasticity in functional neural networks is frequently expressed as gradient descent on a cost. Often, this imposes symmetry constraints that are difficult to reconcile with local…

Neurons and Cognition · Quantitative Biology 2026-04-09 Timo Gierlich , Andreas Baumbach , Akos F. Kungl , Kevin Max , Mihai A. Petrovici

Physics-informed deep learning has emerged as a promising alternative for solving partial differential equations. However, for complex problems, training these networks can still be challenging, often resulting in unsatisfactory accuracy…

Machine Learning · Computer Science 2025-09-18 Wenqian Chen , Amanda A. Howard , Panos Stinis

This work studies approximation based on single-hidden-layer feedforward and recurrent neural networks with randomly generated internal weights. These methods, in which only the last layer of weights and a few hyperparameters are optimized,…

Probability · Mathematics 2021-02-17 Lukas Gonon , Lyudmila Grigoryeva , Juan-Pablo Ortega

Herein the topics of (natural) gradient descent, data decorrelation, and approximate methods for backpropagation are brought into a common discussion. Natural gradient descent illuminates how gradient vectors, pointing at directions of…

Machine Learning · Computer Science 2025-08-26 Nasir Ahmad

Training deep neural networks typically relies on backpropagating high dimensional error signals a computationally intensive process with little evidence supporting its implementation in the brain. However, since most tasks involve…

Machine Learning · Computer Science 2026-01-15 Maher Hanut , Jonathan Kadmon

Machine learning methods are commonly used to solve inverse problems, wherein an unknown signal must be estimated from few indirect measurements generated via a known acquisition procedure. In particular, neural networks perform well…

Machine Learning · Computer Science 2025-12-05 Hannah Laus , Suzanna Parkinson , Vasileios Charisopoulos , Felix Krahmer , Rebecca Willett

The biological plausibility of the backpropagation algorithm has long been doubted by neuroscientists. Two major reasons are that neurons would need to send two different types of signal in the forward and backward phases, and that pairs of…

Machine Learning · Computer Science 2018-08-16 Benjamin Scellier , Anirudh Goyal , Jonathan Binas , Thomas Mesnard , Yoshua Bengio

Backpropagation with gradient descent is a common optimization strategy employed by most neural network architectures in machine learning. However, finding optimal hyperparameters to guide training has proven challenging. While it is widely…

Machine Learning · Computer Science 2026-05-20 Vy Bui , Hang Yu , Karthik Kantipudi , Ziv Yaniv , Stefan Jaeger

In this paper, we develop a new optimization framework for the least squares learning problem via fully connected neural networks or physics-informed neural networks. The gradient descent sometimes behaves inefficiently in deep learning…

Machine Learning · Computer Science 2025-05-01 Yaru Liu , Yiqi Gu , Michael K. Ng

Representations are fundamental to artificial intelligence. The performance of a learning system depends on the type of representation used for representing the data. Typically, these representations are hand-engineered using domain…

Machine Learning · Computer Science 2017-04-28 Vivek Veeriah , Shangtong Zhang , Richard S. Sutton

Backpropagation is the default learning rule for artificial neural networks and is often treated as the settled approach whenever differentiability is available. In this work, we revisit this convention through a theoretical lens of sample…

Machine Learning · Statistics 2026-05-28 Yibo Jacky Zhang , Zeyu Tang , Sanmi Koyejo

Stochastic gradient descent (SGD), a widely used algorithm in deep-learning neural networks has attracted continuing studies for the theoretical principles behind its success. A recent work reports an anomaly (inverse) relation between the…

Adaptation and Self-Organizing Systems · Physics 2023-08-16 Xia Xiong , Yong-Cong Chen , Chunxiao Shi , Ping Ao

It is well understood that neural networks with carefully hand-picked weights provide powerful function approximation and that they can be successfully trained in over-parametrized regimes. Since over-parametrization ensures zero training…

Machine Learning · Computer Science 2024-05-21 G. Welper

Neural networks are popular state-of-the-art models for many different tasks.They are often trained via back-propagation to find a value of the weights that correctly predicts the observed data. Although back-propagation has shown good…

Machine Learning · Statistics 2020-12-29 Simón Rodríguez Santana , Daniel Hernández-Lobato