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Glioblastoma, the most aggressive primary brain tumor, poses a severe clinical challenge due to its diffuse microscopic infiltration, which remains largely undetected on standard MRI. As a result, current radiotherapy planning employs a…

We developed a deep ensemble learning model with a radiomics spatial encoding execution for improved glioma segmentation accuracy using multi-parametric MRI (mp-MRI). This model was developed using 369 glioma patients with a 4-modality…

Quantitative Methods · Quantitative Biology 2023-03-21 Yang Chen , Zhenyu Yang , Jingtong Zhao , Justus Adamson , Yang Sheng , Fang-Fang Yin , Chunhao Wang

Central nervous system (CNS) tumors come with the vastly heterogeneous histologic, molecular and radiographic landscape, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics…

Quantitative Methods · Quantitative Biology 2020-06-30 Andreas Mang , Spyridon Bakas , Shashank Subramanian , Christos Davatzikos , George Biros

Glioblastoma, a highly aggressive brain tumor, poses major challenges due to its poor prognosis and high morbidity rates. Partial differential equation-based models offer promising potential to enhance therapeutic outcomes by simulating…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Zeineb Haouari , Jonas Weidner , Yeray Martin-Ruisanchez , Ivan Ezhov , Aswathi Varma , Daniel Rueckert , Bjoern Menze , Benedikt Wiestler

In this paper, we use the Bayesian inversion approach to study the data assimilation problem for a family of tumor growth models described by porous-medium type equations. The models contain uncertain parameters and are indexed by a…

Numerical Analysis · Mathematics 2024-02-14 Yu Feng , Liu Liu , Zhennan Zhou

Brain tumor growth is unique to each glioma patient and extends beyond what is visible in imaging scans, infiltrating surrounding brain tissue. Understanding these hidden patient-specific progressions is essential for effective therapies.…

Purpose: We aimed to develop a data-driven multiomics approach integrating radiomics, dosiomics, and delta features to predict treatment response at an earlier stage (intra-treatment) for brain metastases (BMs) patients treated with PULSAR.…

Survival prediction models can potentially be used to guide treatment of glioblastoma patients. However, currently available MR imaging biomarkers holding prognostic information are often challenging to interpret, have difficulties…

Image and Video Processing · Electrical Eng. & Systems 2021-09-28 Sveinn Pálsson , Stefano Cerri , Hans Skovgaard Poulsen , Thomas Urup , Ian Law , Koen Van Leemput

Accurate and interpretable classification of brain tumors from magnetic resonance imaging (MRI) is critical for effective diagnosis and treatment planning. This study presents an ensemble-based deep learning framework that combines…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Melika Filvantorkaman , Mohsen Piri , Maral Filvan Torkaman , Ashkan Zabihi , Hamidreza Moradi

Recent advances in deep learning have significantly improved brain tumour segmentation techniques; however, the results still lack confidence and robustness as they solely consider image data without biophysical priors or pathological…

Image and Video Processing · Electrical Eng. & Systems 2024-10-10 Lipei Zhang , Yanqi Cheng , Lihao Liu , Carola-Bibiane Schönlieb , Angelica I Aviles-Rivero

Glioma, an aggressive brain malignancy characterized by rapid progression and its poor prognosis, poses significant challenges for accurate evolution prediction. These challenges are exacerbated by sparse, irregularly acquired longitudinal…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Aghiles Kebaili , Romain Modzelewski , Jérôme Lapuyade-Lahorgue , Maxime Fontanilles , Sébastien Thureau , Su Ruan

The accurate classification of brain tumors from MRI scans is essential for effective diagnosis and treatment planning. This paper presents a weighted ensemble learning approach that combines deep learning and traditional machine learning…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Ha Anh Vu

Segmentation of brain tumor from magnetic resonance imaging (MRI) is a vital process to improve diagnosis, treatment planning and to study the difference between subjects with tumor and healthy subjects. In this paper, we exploit a…

Image and Video Processing · Electrical Eng. & Systems 2021-04-05 Mobarakol Islam , V Jeya Maria Jose , Hongliang Ren

Brain tumors are abnormal cell growths in the central nervous system (CNS), and their timely detection is critical for improving patient outcomes. This paper proposes an automatic and efficient deep-learning framework for brain tumor…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Ahta-Shamul Hoque Emran , Hafija Akter , Abdullah Al Shiam , Abu Saleh Musa Miah , Anichur Rahman , Fahmid Al Farid , Hezerul Abdul Karim

Physical models in the form of partial differential equations serve as important priors for many under-constrained problems. One such application is tumor treatment planning, which relies on accurately estimating the spatial distribution of…

To improve patient survival and treatment outcomes, early diagnosis of brain tumors is an essential task. It is a difficult task to evaluate the magnetic resonance imaging (MRI) images manually. Thus, there is a need for digital methods for…

Computer Vision and Pattern Recognition · Computer Science 2021-01-05 Ginni Garg , Ritu Garg

Understanding the dynamics of brain tumor progression is essential for optimal treatment planning. Cast in a mathematical formulation, it is typically viewed as evaluation of a system of partial differential equations, wherein the…

Quantitative Methods · Quantitative Biology 2020-01-13 Ivan Ezhov , Jana Lipkova , Suprosanna Shit , Florian Kofler , Nore Collomb , Benjamin Lemasson , Emmanuel Barbier , Bjoern Menze

Segmentation of brain tumors is a critical step in treatment planning, yet manual segmentation is both time-consuming and subjective, relying heavily on the expertise of radiologists. In Sub-Saharan Africa, this challenge is magnified by…

Glioblastoma are known to infiltrate the brain parenchyma instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly. In contrast, brain…

The concept of tumor field effect implies that cancer is a systemic disease with its impact way beyond the visible tumor confines. For instance, in Glioblastoma (GBM), an aggressive brain tumor, the increase in intracranial pressure due to…