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Reliable cell segmentation and classification from biomedical images is a crucial step for both scientific research and clinical practice. A major challenge for more robust segmentation and classification methods is the large variations in…

Cell Behavior · Quantitative Biology 2017-10-31 Mo Zhang , Xiang Li , Mengjia Xu , Quanzheng Li

Separating and labeling each instance of a nucleus (instance-aware segmentation) is the key challenge in segmenting single cell nuclei on fluorescence microscopy images. Deep Neural Networks can learn the implicit transformation of a…

Computer Vision and Pattern Recognition · Computer Science 2021-08-11 Florian Kromp , Lukas Fischer , Eva Bozsaky , Inge Ambros , Wolfgang Doerr , Sabine Taschner-Mandl , Peter Ambros , Allan Hanbury

Understanding the morphological structure of medical images and precisely segmenting the region of interest or abnormality is an important task that can assist in diagnosis. However, the unique properties of medical imaging make clear…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Sungmin Kang , Jaeha Song , Jihie Kim

Biomedical image segmentation is crucial for accurately diagnosing and analyzing various diseases. However, Convolutional Neural Networks (CNNs) and Transformers, the most commonly used architectures for this task, struggle to effectively…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Rong Zhou , Zhengqing Yuan , Zhiling Yan , Weixiang Sun , Kai Zhang , Yiwei Li , Yanfang Ye , Xiang Li , Lifang He , Lichao Sun

We propose a novel transformer model, capable of segmenting medical images of varying modalities. Challenges posed by the fine grained nature of medical image analysis mean that the adaptation of the transformer for their analysis is still…

Image and Video Processing · Electrical Eng. & Systems 2023-01-31 Athanasios Tragakis , Chaitanya Kaul , Roderick Murray-Smith , Dirk Husmeier

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

Due to cellular heterogeneity, cell nuclei classification, segmentation, and detection from pathological images are challenging tasks. In the last few years, Deep Convolutional Neural Networks (DCNN) approaches have been shown…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Md Zahangir Alom , Chris Yakopcic , Tarek M. Taha , Vijayan K. Asari

Cell instance segmentation in cytology images has significant importance for biology analysis and cancer screening, while remains challenging due to 1) the extensive overlapping translucent cell clusters that cause the ambiguous boundaries,…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Hao Jiang , Rushan Zhang , Yanning Zhou , Yumeng Wang , Hao Chen

There is large consent that successful training of deep networks requires many thousand annotated training samples. In this paper, we present a network and training strategy that relies on the strong use of data augmentation to use the…

Computer Vision and Pattern Recognition · Computer Science 2015-05-19 Olaf Ronneberger , Philipp Fischer , Thomas Brox

Nuclei detection and segmentation in hematoxylin and eosin-stained (H&E) tissue images are important clinical tasks and crucial for a wide range of applications. However, it is a challenging task due to nuclei variances in staining and…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Fabian Hörst , Moritz Rempe , Lukas Heine , Constantin Seibold , Julius Keyl , Giulia Baldini , Selma Ugurel , Jens Siveke , Barbara Grünwald , Jan Egger , Jens Kleesiek

Identify the cells' nuclei is the important point for most medical analyses. To assist doctors finding the accurate cell' nuclei location automatically is highly demanded in the clinical practice. Recently, fully convolutional neural…

Computer Vision and Pattern Recognition · Computer Science 2019-11-25 Tianyang Zhang , Rui Ma

Medical image segmentation plays a crucial role in clinical diagnosis and treatment planning. Although models based on convolutional neural networks (CNNs) and Transformers have achieved remarkable success in medical image segmentation…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Jiashu Xu

Deep learning has revolutionized medical and biological imaging, particularly in segmentation tasks. However, segmenting biological cells remains challenging due to the high variability and complexity of cell shapes. Addressing this…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Tianhao Zhang , Heather J. McCourty , Berardo M. Sanchez-Tafolla , Anton Nikolaev , Lyudmila S. Mihaylova

Feature foundation models - usually vision transformers - offer rich semantic descriptors of images, useful for downstream tasks such as (interactive) segmentation and object detection. For computational efficiency these descriptors are…

Computer Vision and Pattern Recognition · Computer Science 2025-09-01 Ronan Docherty , Antonis Vamvakeros , Samuel J. Cooper

Cell detection in microscopy images is important to study how cells move and interact with their environment. Most recent deep learning-based methods for cell detection use convolutional neural networks (CNNs). However, inspired by the…

Image and Video Processing · Electrical Eng. & Systems 2022-06-15 Royden Wagner , Karl Rohr

Medical image segmentation is an important step in medical image analysis, especially as a crucial prerequisite for efficient disease diagnosis and treatment. The use of deep learning for image segmentation has become a prevalent trend. The…

Image and Video Processing · Electrical Eng. & Systems 2023-08-11 Wenjian Yao , Jiajun Bai , Wei Liao , Yuheng Chen , Mengjuan Liu , Yao Xie

The automated analysis of microscopy images is a challenge in the context of single-cell tracking and quantification. This work has as goals the study of the performance of deep learning for segmenting microscopy images and the improvement…

Quantitative Methods · Quantitative Biology 2022-10-05 André O. Françani

Studying cell morphology changes in time is critical to understanding cell migration mechanisms. In this work, we present a deep learning-based workflow to segment cancer cells embedded in 3D collagen matrices and imaged with phase-contrast…

Computer Vision and Pattern Recognition · Computer Science 2021-12-17 Estibaliz Gómez-de-Mariscal , Hasini Jayatilaka , Özgün Çiçek , Thomas Brox , Denis Wirtz , Arrate Muñoz-Barrutia

This paper proposes to use Fast Fourier Transformation-based U-Net (a refined fully convolutional networks) and perform image convolution in neural networks. Leveraging the Fast Fourier Transformation, it reduces the image convolution costs…

Computer Vision and Pattern Recognition · Computer Science 2020-10-12 Varsha Nair , Moitrayee Chatterjee , Neda Tavakoli , Akbar Siami Namin , Craig Snoeyink

Accurately segmenting and individualizing cells in SEM images is a highly promising technique for elucidating tissue architecture in oncology. While current AI-based methods are effective, errors persist, necessitating time-consuming manual…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Florian Robert , Alexia Calovoulos , Laurent Facq , Fanny Decoeur , Etienne Gontier , Christophe F. Grosset , Baudouin Denis de Senneville
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