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The dynamics of single cell migration on flat surfaces is usually modeled by a Langevin-like problem consisting of ballistic motion for short periods and random walk. for long periods. Conversely, recent studies have revealed a previously…

Vector Auto-Regressive (VAR) models capture lead-lag temporal dynamics of multivariate time series data. They have been widely used in macroeconomics, financial econometrics, neuroscience and functional genomics. In many applications, the…

Methodology · Statistics 2021-10-15 Peiliang Bai , Yue Bai , Abolfazl Safikhani , George Michailidis

This paper studies the problem of separating phase-amplitude components in sample paths of a spherical process (longitudinal data on a unit two-sphere). Such separation is essential for efficient modeling and statistical analysis of…

Methodology · Statistics 2016-03-24 Zhengwu Zhang , Eric Klassen , Anuj Srivastava

Among the main actors of organism development there are morphogens, which are signaling molecules diffusing in the developing organism and acting on cells to produce local responses. Growth is thus determined by the distribution of such…

Optimization and Control · Mathematics 2016-09-21 Francesco Rossi , Nastassia Pouradier Duteil , Nir Yakoby , Benedetto Piccoli

Eukaryotic cell motility involves a complex network of interactions between biochemical components and mechanical processes. The cell employs this network to polarize and induce shape changes that give rise to membrane protrusions and…

Cell Behavior · Quantitative Biology 2022-01-03 E. Moreno , S. Flemming , F. Font , M. Holschneider , C. Beta , S. Alonso

Synchronization of mobile oscillators occurs in numerous contexts, including physical, chemical, biological and engineered systems. In vertebrate embryonic development, a segmental body structure is generated by a population of mobile…

Pattern Formation and Solitons · Physics 2024-06-18 Koichiro Uriu , Luis G. Morelli

This paper introduces a novel computational framework for modeling and analyzing the spatiotemporal shape variability of tree-like 4D structures whose shapes deform and evolve over time. Tree-like 3D objects, such as botanical trees and…

Computational Geometry · Computer Science 2025-09-24 Tahmina Khanam , Hamid Laga , Mohammed Bennamoun , Guanjin Wang , Ferdous Sohel , Farid Boussaid , Guan Wang , Anuj Srivastava

Collective migration dominates many phenomena, from cell movement in living systems to abiotic self-propelling particles. Focusing on the early stages of tumor evolution, we enunciate the principles involved in cell dynamics and highlight…

Cell Behavior · Quantitative Biology 2018-05-02 Abdul N Malmi-Kakkada , Xin Li , Himadri S. Samanta , Sumit Sinha , D. Thirumalai

Spatiotemporal imaging has applications in e.g. cardiac diagnostics, surgical guidance, and radiotherapy monitoring, In this paper, we explain the temporal motion by identifying the underlying dynamics, only based on the sequential images.…

Medical Physics · Physics 2024-10-16 Niklas Gunnarsson , Peter Kimstrand , Jens Sjölund , Thomas B. Schön

The initiation of directional cell motion requires symmetry breaking that can happen both with or without external stimuli. During cell crawling, forces generated by the cytoskeleton and their transmission through mechanosensitive adhesions…

Cell Behavior · Quantitative Biology 2023-06-02 Yuzhu Chen , David Saintillan , Padmini Rangamani

Understanding how neuronal networks reorganize in response to external stimuli and give rise to behavior is a central challenge in neuroscience and artificial intelligence. However, existing methods often fail to capture the evolving…

Neurons and Cognition · Quantitative Biology 2025-06-02 Moein Khajehnejad , Forough Habibollahi , Ahmad Khajehnejad , Chris French , Brett J. Kagan , Adeel Razi

In this paper, we write the time-varying parameter (TVP) regression model involving K explanatory variables and T observations as a constant coefficient regression model with KT explanatory variables. In contrast with much of the existing…

Econometrics · Economics 2021-10-01 Niko Hauzenberger , Florian Huber , Gary Koop , Luca Onorante

Cell polarity and movement are fundamental to many biological functions. Experimental and theoretically studies have indicated that interactions of certain proteins lead to the cell polarization which plays a key role in controlling the…

Dynamical Systems · Mathematics 2022-08-12 Shuang Liu , Li-Tien Cheng , Bo Li

This article presents an Analysis of Variance model for functional data that explicitly incorporates phase variability through a time-warping component, allowing for a unified approach to estimation and inference in presence of amplitude…

Methodology · Statistics 2013-11-11 Daniel Gervini , Patrick A. Carter

Dynamic graph-level embedding aims to capture structural evolution in networks, which is essential for modeling real-world scenarios. However, existing methods face two critical yet under-explored issues: Structural Visit Bias, where random…

Machine Learning · Computer Science 2025-08-22 Haodi Zhong , Liuxin Zou , Di Wang , Bo Wang , Zhenxing Niu , Quan Wang

In this paper, we study the statistical evolution of the large-scale structure (LSS), focusing on the joint probability distribution function (PDF) of the coarse-grained cosmic field and its role in constructing effective dynamics. As the…

Cosmology and Nongalactic Astrophysics · Physics 2021-10-20 Xin Wang

Cell migration, which can be significantly affected by intracellular signaling pathways (ICSP) and extracellular matrix (ECM), plays a crucial role in many physiological and pathological processes. The efficiency of cell migration, which is…

Biological Physics · Physics 2021-07-07 Yanping Liu , Yang Jiao , Qihui Fan , Guoqiang Li , Jingru Yao , Gao Wang , Silong Lou , Guo Chen , Jianwei Shuai , Liyu Liu

Recent deep generative models are able to provide photo-realistic images as well as visual or textual content embeddings useful to address various tasks of computer vision and natural language processing. Their usefulness is nevertheless…

Machine Learning · Computer Science 2020-01-29 Antoine Plumerault , Hervé Le Borgne , Céline Hudelot

This paper deals with flow-induced shape transitions of elastic capsules. The state of the art concerning both theory and experiments is briefly reviewed starting with dynamically induced small deformation of initially spherical capsules…

Soft Condensed Matter · Physics 2011-04-25 Reimar Finken , Steffen Kessler , Udo Seifert

Morphological trends in growing colonies of living cells are at the core of physiological and evolutionary processes. Using active gel equations, which include cell division, we show that shape changes during the growth can be regulated by…

Soft Condensed Matter · Physics 2016-07-27 Amin Doostmohammadi , Sumesh P. Thampi , Julia M. Yeomans