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Deep learning models are vulnerable to performance degradation when encountering out-of-distribution (OOD) images, potentially leading to misdiagnoses and compromised patient care. These shortcomings have led to great interest in the field…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Lars Doorenbos , Raphael Sznitman , Pablo Márquez-Neila

The high performance of denoising diffusion models for image generation has paved the way for their application in unsupervised medical anomaly detection. As diffusion-based methods require a lot of GPU memory and have long sampling times,…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Julia Wolleb , Florentin Bieder , Paul Friedrich , Peter Zhang , Alicia Durrer , Philippe C. Cattin

It is important to detect anomalous inputs when deploying machine learning systems. The use of larger and more complex inputs in deep learning magnifies the difficulty of distinguishing between anomalous and in-distribution examples. At the…

Machine Learning · Computer Science 2019-01-30 Dan Hendrycks , Mantas Mazeika , Thomas Dietterich

In this paper, we propose the Adversarial Denoising Diffusion Model (ADDM). The ADDM is based on the Denoising Diffusion Probabilistic Model (DDPM) but complementarily trained by adversarial learning. The proposed adversarial learning is…

Image and Video Processing · Electrical Eng. & Systems 2023-12-08 Jongmin Yu , Hyeontaek Oh , Jinhong Yang

Obtaining labels for medical (image) data requires scarce and expensive experts. Moreover, due to ambiguous symptoms, single images rarely suffice to correctly diagnose a medical condition. Instead, it often requires to take additional…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Diana Davletshina , Valentyn Melnychuk , Viet Tran , Hitansh Singla , Max Berrendorf , Evgeniy Faerman , Michael Fromm , Matthias Schubert

Expert interpretation of anatomical images of the human brain is the central part of neuro-radiology. Several machine learning-based techniques have been proposed to assist in the analysis process. However, the ML models typically need to…

The automatic detection of skin diseases via dermoscopic images can improve the efficiency in diagnosis and help doctors make more accurate judgments. However, conventional skin disease recognition systems may produce high confidence for…

Computer Vision and Pattern Recognition · Computer Science 2023-01-19 Zhongzheng Huang , Tao Wang , Yuanzheng Cai , Lingyu Liang

Unsupervised anomaly detection (AD) in medical images aims to identify abnormal regions without relying on pixel-level annotations, which is crucial for scalable and label-efficient diagnostic systems. In this paper, we propose a novel…

Image and Video Processing · Electrical Eng. & Systems 2026-02-05 Jiayu Huo , Jingyuan Hong , Liyun Chen

Unsupervised Anomaly detection (AD) requires building a notion of normalcy, distinguishing in-distribution (ID) and out-of-distribution (OOD) data, using only available ID samples. Recently, large gains were made on this task for the domain…

Computer Vision and Pattern Recognition · Computer Science 2022-03-22 Mohamed Yousef , Marcel Ackermann , Unmesh Kurup , Tom Bishop

We propose a deformable registration algorithm based on unsupervised learning of a low-dimensional probabilistic parameterization of deformations. We model registration in a probabilistic and generative fashion, by applying a conditional…

Computer Vision and Pattern Recognition · Computer Science 2018-07-23 Julian Krebs , Tommaso Mansi , Boris Mailhé , Nicholas Ayache , Hervé Delingette

Deep generative models have been demonstrated as problematic in the unsupervised out-of-distribution (OOD) detection task, where they tend to assign higher likelihoods to OOD samples. Previous studies on this issue are usually not…

Machine Learning · Computer Science 2024-01-04 Zezhen Zeng , Bin Liu

Anomalies are samples that significantly deviate from the rest of the data and their detection plays a major role in building machine learning models that can be reliably used in applications such as data-driven design and novelty…

Machine Learning · Statistics 2023-06-19 Amin Yousefpour , Mehdi Shishehbor , Zahra Zanjani Foumani , Ramin Bostanabad

Anomaly detection in medical images refers to the identification of abnormal images with only normal images in the training set. Most existing methods solve this problem with a self-reconstruction framework, which tends to learn an identity…

Image and Video Processing · Electrical Eng. & Systems 2021-10-06 Kang Zhou , Jing Li , Weixin Luo , Zhengxin Li , Jianlong Yang , Huazhu Fu , Jun Cheng , Jiang Liu , Shenghua Gao

Generative models are popular for medical imaging tasks such as anomaly detection, feature extraction, data visualization, or image generation. Since they are parameterized by deep learning models, they are often sensitive to distribution…

Machine Learning · Computer Science 2025-03-25 Miguel López-Pérez , Marco Miani , Valery Naranjo , Søren Hauberg , Aasa Feragen

Semantic segmentation models trained on known object classes often fail in real-world autonomous driving scenarios by confidently misclassifying unknown objects. While pixel-wise out-of-distribution detection can identify unknown objects,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-04 Marc Hölle , Walter Kellermann , Vasileios Belagiannis

Deep Learning (DL) models tend to perform poorly when the data comes from a distribution different from the training one. In critical applications such as medical imaging, out-of-distribution (OOD) detection helps to identify such data…

Image and Video Processing · Electrical Eng. & Systems 2023-06-26 Daria Frolova , Anton Vasiliuk , Mikhail Belyaev , Boris Shirokikh

The recent prevalence of deep neural networks has lead semantic segmentation networks to achieve human-level performance in the medical field when sufficient training data is provided. Such networks however fail to generalize when tasked…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Serban Stan , Mohammad Rostami

Tables are an abundant form of data with use cases across all scientific fields. Real-world datasets often contain anomalous samples that can negatively affect downstream analysis. In this work, we only assume access to contaminated data…

Machine Learning · Computer Science 2023-07-25 Guy Zamberg , Moshe Salhov , Ofir Lindenbaum , Amir Averbuch

Sarcopenia is an age-related progressive loss of muscle mass and strength that significantly impacts daily life. A commonly studied criterion for characterizing the muscle mass has been the combination of 3D imaging and manual…

Computer Vision and Pattern Recognition · Computer Science 2025-02-14 Louise Piecuch , Jeremie Huet , Antoine Frouin , Antoine Nordez , Anne-Sophie Boureau , Diana Mateus

The identification and quantification of markers in medical images is critical for diagnosis, prognosis and management of patients in clinical practice. Supervised- or weakly supervised training enables the detection of findings that are…