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In medical imaging, un-, semi-, or self-supervised pathology detection is often approached with anomaly- or out-of-distribution detection methods, whose inductive biases are not intentionally directed towards detecting pathologies, and are…

Image and Video Processing · Electrical Eng. & Systems 2022-01-25 Felix Meissen , Georgios Kaissis , Daniel Rueckert

Deep generative networks trained via maximum likelihood on a natural image dataset like CIFAR10 often assign high likelihoods to images from datasets with different objects (e.g., SVHN). We refine previous investigations of this failure at…

Machine Learning · Computer Science 2020-11-03 Robin Tibor Schirrmeister , Yuxuan Zhou , Tonio Ball , Dan Zhang

Unsupervised anomaly segmentation approaches to pathology segmentation train a model on images of healthy subjects, that they define as the 'normal' data distribution. At inference, they aim to segment any pathologies in new images as…

Image and Video Processing · Electrical Eng. & Systems 2024-06-06 Ziyun Liang , Xiaoqing Guo , J. Alison Noble , Konstantinos Kamnitsas

When neural networks process images which do not resemble the distribution seen during training, so called out-of-distribution images, they often make wrong predictions, and do so too confidently. The capability to detect…

Computer Vision and Pattern Recognition · Computer Science 2018-12-13 Marc Masana , Idoia Ruiz , Joan Serrat , Joost van de Weijer , Antonio M. Lopez

Anomaly detection in medical imaging plays a crucial role in identifying pathological regions across various imaging modalities, such as brain MRI, liver CT, and carotid ultrasound (US). However, training fully supervised segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Yuan Bi , Lucie Huang , Ricarda Clarenbach , Reza Ghotbi , Angelos Karlas , Nassir Navab , Zhongliang Jiang

Variational Auto-Encoders (VAEs) have shown great potential in the unsupervised learning of data distributions. An VAE trained on normal images is expected to only be able to reconstruct normal images, allowing the localization of anomalous…

Computer Vision and Pattern Recognition · Computer Science 2020-05-22 Leixin Zhou , Wenxiang Deng , Xiaodong Wu

This review explores anomaly localization in medical images using denoising diffusion models. After providing a brief methodological background of these models, including their application to image reconstruction and their conditioning…

Image and Video Processing · Electrical Eng. & Systems 2025-12-15 Cosmin I. Bercea , Philippe C. Cattin , Julia A. Schnabel , Julia Wolleb

Unsupervised anomaly detection in brain images is crucial for identifying injuries and pathologies without access to labels. However, the accurate localization of anomalies in medical images remains challenging due to the inherent…

Computer Vision and Pattern Recognition · Computer Science 2025-07-25 Farzad Beizaee , Gregory Lodygensky , Christian Desrosiers , Jose Dolz

The increasing complexity of medical imaging data underscores the need for advanced anomaly detection methods to automatically identify diverse pathologies. Current methods face challenges in capturing the broad spectrum of anomalies, often…

Image and Video Processing · Electrical Eng. & Systems 2024-01-22 Cosmin I. Bercea , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel

Detection of visual anomalies refers to the problem of finding patterns in different imaging data that do not conform to the expected visual appearance and is a widely studied problem in different domains. Due to the nature of anomaly…

Image and Video Processing · Electrical Eng. & Systems 2021-04-29 Dejan Stepec , Danijel Skocaj

Deep learning has now become the de facto approach to the recognition of anomalies in medical imaging. Their 'black box' way of classifying medical images into anomaly labels poses problems for their acceptance, particularly with…

Computer Vision and Pattern Recognition · Computer Science 2020-08-04 Satyananda Kashyap , Alexandros Karargyris , Joy Wu , Yaniv Gur , Arjun Sharma , Ken C. L. Wong , Mehdi Moradi , Tanveer Syeda-Mahmood

Anomaly detection without priors of the anomalies is challenging. In the field of unsupervised anomaly detection, traditional auto-encoder (AE) tends to fail based on the assumption that by training only on normal images, the model will not…

Computer Vision and Pattern Recognition · Computer Science 2024-08-15 Yajie Cui , Zhaoxiang Liu , Shiguo Lian

Segmentation masks of pathological areas are useful in many medical applications, such as brain tumour and stroke management. Moreover, healthy counterfactuals of diseased images can be used to enhance radiologists' training files and to…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Alessandro Fontanella , Grant Mair , Joanna Wardlaw , Emanuele Trucco , Amos Storkey

The detection and the quantification of anomalies in image data are critical tasks in industrial scenes such as detecting micro scratches on product. In recent years, due to the difficulty of defining anomalies and the limit of correcting…

Computer Vision and Pattern Recognition · Computer Science 2018-11-08 Masanari Kimura , Takashi Yanagihara

Existing image segmentation networks mainly leverage large-scale labeled datasets to attain high accuracy. However, labeling medical images is very expensive since it requires sophisticated expert knowledge. Thus, it is more desirable to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-04 Yuhang Ding , Xin Yu , Yi Yang

Deep learning models in medical imaging often encounter challenges when adapting to new clinical settings unseen during training. Test-time adaptation offers a promising approach to optimize models for these unseen domains, yet its…

Machine Learning · Computer Science 2024-10-28 Sameer Ambekar , Julia A. Schnabel , Cosmin I. Bercea

The detection and localization of possible diseases in crops are usually automated by resorting to supervised deep learning approaches. In this work, we tackle these goals with unsupervised models, by applying three different types of…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Davide Calabrò , Massimiliano Lupo Pasini , Nicola Ferro , Simona Perotto

Unsupervised anomaly detection and localization is crucial to the practical application when collecting and labeling sufficient anomaly data is infeasible. Most existing representation-based approaches extract normal image features with a…

Computer Vision and Pattern Recognition · Computer Science 2021-11-17 Jiawei Yu , Ye Zheng , Xiang Wang , Wei Li , Yushuang Wu , Rui Zhao , Liwei Wu

Contrastive representation learning has emerged as an outstanding approach for anomaly detection. In this work, we explore the $\ell_2$-norm of contrastive features and its applications in out-of-distribution detection. We propose a simple…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Tai Le-Gia , Jaehyun Ahn

It has recently been shown that deep learning models for anatomical segmentation in medical images can exhibit biases against certain sub-populations defined in terms of protected attributes like sex or ethnicity. In this context, auditing…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Nicolás Gaggion , Rodrigo Echeveste , Lucas Mansilla , Diego H. Milone , Enzo Ferrante