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This paper describes a method for a model-based analysis of clinical safety data called multivariate Bayesian logistic regression (MBLR). Parallel logistic regression models are fit to a set of medically related issues, or response…

Methodology · Statistics 2012-10-02 William DuMouchel

Despite their widespread applications, Large Language Models (LLMs) often struggle to express uncertainty, posing a challenge for reliable deployment in high stakes and safety critical domains like clinical diagnostics. Existing standard…

Machine Learning · Computer Science 2025-09-25 Mridul Sharma , Adeetya Patel , Zaneta D' Souza , Samira Abbasgholizadeh Rahimi , Siva Reddy , Sreenath Madathil

Distributed statistical inference has recently attracted immense attention. The asymptotic efficiency of the maximum likelihood estimator (MLE), the one-step MLE, and the aggregated estimating equation estimator are established for…

Methodology · Statistics 2020-08-14 Ping Zhou , Zhen Yu , Jingyi Ma , Maozai Tian , Ye Fan

Deep Learning (DL) methods have emerged as one of the most powerful tools for functional approximation and prediction. While the representation properties of DL have been well studied, uncertainty quantification remains challenging and…

Machine Learning · Statistics 2022-10-25 Yuexi Wang , Nicholas G. Polson , Vadim O. Sokolov

Generalized linear models (GLMs) are routinely used for modeling relationships between a response variable and a set of covariates. The simple form of a GLM comes with easy interpretability, but also leads to concerns about model…

Methodology · Statistics 2023-11-10 Davide Agnoletto , Tommaso Rigon , David B. Dunson

To facilitate robust and trustworthy deployment of large language models (LLMs), it is essential to quantify the reliability of their generations through uncertainty estimation. While recent efforts have made significant advancements by…

Computation and Language · Computer Science 2025-07-22 Rui Li , Jing Long , Muge Qi , Heming Xia , Lei Sha , Peiyi Wang , Zhifang Sui

An optimal experimental set-up maximizes the value of data for statistical inferences and predictions. The efficiency of strategies for finding optimal experimental set-ups is particularly important for experiments that are time-consuming…

Numerical Analysis · Mathematics 2020-02-04 Joakim Beck , Ben Mansour Dia , Luis F. R. Espath , Raul Tempone

Confidence sequences based on test martingales provide time-uniform uncertainty quantification for the mean of bounded IID observations without parametric distributional assumptions. Their practical efficiency, however, depends strongly on…

Machine Learning · Statistics 2026-05-12 Valentin Kilian , Stefano Cortinovis , François Caron

We propose a clustered local projection (clustered LP) method to estimate impulse response functions in a class of time-varying models where parameter variation is linked to a low-dimensional matrix of observables. We show that the…

Econometrics · Economics 2026-05-04 Ana Maria Herrera , Elena Pesavento , Alessia Scudiero

The constrained local model (CLM) proposes a paradigm that the locations of a set of local landmark detectors are constrained to lie in a subspace, spanned by a shape point distribution model (PDM). Fitting the model to an object involves…

Computer Vision and Pattern Recognition · Computer Science 2016-12-01 Hailiang Li , Kin-Man Lam , Man-Yau Chiu , Kangheng Wu , Zhibin Lei

Nowadays insurers have to account for potentially complex dependence between risks. In the field of loss reserving, there are many parametric and non-parametric models attempting to capture dependence between business lines. One common…

Methodology · Statistics 2024-10-22 Andrew Fleck , Edward Furman , Yang Shen

We develop a Bayesian framework for variable selection in linear regression with autocorrelated errors, accommodating lagged covariates and autoregressive structures. This setting occurs in time series applications where responses depend on…

Methodology · Statistics 2025-08-18 Alokesh Manna , Sujit K. Ghosh

We study the distribution of the maximum likelihood estimate (MLE) in high-dimensional logistic models, extending the recent results from Sur (2019) to the case where the Gaussian covariates may have an arbitrary covariance structure. We…

Statistics Theory · Mathematics 2023-01-05 Qian Zhao , Pragya Sur , Emmanuel J. Candès

Continual Learning (CL) strives to learn incrementally across tasks while mitigating catastrophic forgetting. A key challenge in CL is balancing stability (retaining prior knowledge) and plasticity (learning new tasks). While representative…

Machine Learning · Computer Science 2025-05-30 Mei Li , Yuxiang Lu , Qinyan Dai , Suizhi Huang , Yue Ding , Hongtao Lu

Active learning is a machine learning paradigm that aims to improve the performance of a model by strategically selecting and querying unlabeled data. One effective selection strategy is to base it on the model's predictive uncertainty,…

Machine Learning · Computer Science 2024-05-17 Seong Jin Cho , Gwangsu Kim , Junghyun Lee , Jinwoo Shin , Chang D. Yoo

Analog dynamical accelerators (DXs) are a growing sub-field in computer architecture research, offering order-of-magnitude gains in power efficiency and latency over traditional digital methods in several machine learning, optimization, and…

Machine Learning · Computer Science 2025-05-08 Matthew X. Burns , Qingyuan Hou , Michael C. Huang

State-space models have been used in many applications, including econometrics, engineering, medical research, etc. The maximum likelihood estimation (MLE) of the static parameter of general state-space models is not straightforward because…

Methodology · Statistics 2025-02-04 Yuxiong Gao , Wentao Li , Rong Chen

We introduce the Locally Linear Latent Variable Model (LL-LVM), a probabilistic model for non-linear manifold discovery that describes a joint distribution over observations, their manifold coordinates and locally linear maps conditioned on…

Machine Learning · Statistics 2015-12-02 Mijung Park , Wittawat Jitkrittum , Ahmad Qamar , Zoltan Szabo , Lars Buesing , Maneesh Sahani

The beta distribution serves as a canonical tool for modeling probabilities in statistics and machine learning. However, there is limited work on flexible and computationally convenient stochastic process extensions for modeling dependent…

Methodology · Statistics 2025-03-18 Changwoo J. Lee , Alessandro Zito , Huiyan Sang , David B. Dunson

We propose Local Momentum Tracking (LMT), a novel distributed stochastic gradient method for solving distributed optimization problems over networks. To reduce communication overhead, LMT enables each agent to perform multiple local updates…

Optimization and Control · Mathematics 2025-11-10 Kun Huang , Shi Pu