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One of the key steps in building deep learning systems for drug classification and generation is the choice of featurization for the molecules. Previous featurization methods have included molecular images, binary strings, graphs, and…

Computer Vision and Pattern Recognition · Computer Science 2020-08-11 Daniel de Marchi , Amarjit Budhiraja

Graph neural networks (GNNs) have demonstrated promising performance across various chemistry-related tasks. However, conventional graphs only model the pairwise connectivity in molecules, failing to adequately represent higher-order…

Chemical Physics · Physics 2023-12-22 Junwu Chen , Philippe Schwaller

Feature matching is a cornerstone task in computer vision, essential for applications such as image retrieval, stereo matching, 3D reconstruction, and SLAM. This survey comprehensively reviews modality-based feature matching, exploring…

Computer Vision and Pattern Recognition · Computer Science 2025-07-31 Weide Liu , Wei Zhou , Jun Liu , Ping Hu , Jun Cheng , Jungong Han , Weisi Lin

Ground-state 3D geometries of molecules are essential for many molecular analysis tasks. Modern quantum mechanical methods can compute accurate 3D geometries but are computationally prohibitive. Currently, an efficient alternative to…

Chemical Physics · Physics 2023-05-24 Zhao Xu , Yaochen Xie , Youzhi Luo , Xuan Zhang , Xinyi Xu , Meng Liu , Kaleb Dickerson , Cheng Deng , Maho Nakata , Shuiwang Ji

Drug Discovery is a fundamental and ever-evolving field of research. The design of new candidate molecules requires large amounts of time and money, and computational methods are being increasingly employed to cut these costs. Machine…

Machine Learning · Statistics 2021-05-28 Pietro Bongini , Monica Bianchini , Franco Scarselli

On-device learning has emerged as a prevailing trend that avoids the slow response time and costly communication of cloud-based learning. The ability to learn continuously and indefinitely in a changing environment, and with resource…

Machine Learning · Computer Science 2024-03-08 Xiaofan Yu , Anthony Thomas , Ivannia Gomez Moreno , Louis Gutierrez , Tajana Rosing

Molecular docking is a key computational tool utilized to predict the binding conformations of small molecules to protein targets, which is fundamental in the design of novel drugs. Despite recent advancements in geometric deep…

Biomolecules · Quantitative Biology 2023-12-01 Jiaxian Yan , Zaixi Zhang , Kai Zhang , Qi Liu

Accurate and efficient prediction of polymer properties is of key importance for polymer design. Traditional experimental tools and density function theory (DFT)-based simulations for polymer property evaluation, are both expensive and…

Materials Science · Physics 2024-10-08 Cong Shen , Yipeng Zhang , Fei Han , Kelin Xia

Hyperdimensional computing (HDC) is an emerging computing paradigm with significant promise for efficient and robust learning. In HDC, objects are encoded with high-dimensional vector symbolic sequences called hypervectors. The quality of…

Machine Learning · Computer Science 2023-11-20 Sercan Aygun , M. Hassan Najafi

Embedding invisible hyperlinks or hidden codes in images to replace QR codes has become a hot topic recently. This technology requires first localizing the embedded region in the captured photos before decoding. Existing methods that train…

Computer Vision and Pattern Recognition · Computer Science 2024-05-07 Chengxin Zhao , Hefei Ling , Sijing Xie , Nan Sun , Zongyi Li , Yuxuan Shi , Jiazhong Chen

The problem of accelerating drug discovery relies heavily on automatic tools to optimize precursor molecules to afford them with better biochemical properties. Our work in this paper substantially extends prior state-of-the-art on…

Chemical Physics · Physics 2019-10-22 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Molecular and genomic properties are critical in selecting cancer treatments to target individual tumors, particularly for immunotherapy. However, the methods to assess such properties are expensive, time-consuming, and often not routinely…

Image and Video Processing · Electrical Eng. & Systems 2022-11-29 Heather D. Couture

Searching for novel molecules with desired chemical properties is crucial in drug discovery. Existing work focuses on developing neural models to generate either molecular sequences or chemical graphs. However, it remains a big challenge to…

Biomolecules · Quantitative Biology 2021-03-22 Yutong Xie , Chence Shi , Hao Zhou , Yuwei Yang , Weinan Zhang , Yong Yu , Lei Li

Motivation Protein fold recognition is an important problem in structural bioinformatics. Almost all traditional fold recognition methods use sequence (homology) comparison to indirectly predict the fold of a tar get protein based on the…

Machine Learning · Computer Science 2017-06-06 Jie Hou , Badri Adhikari , Jianlin Cheng

Chemical representation learning has gained increasing interest due to the limited availability of supervised data in fields such as drug and materials design. This interest particularly extends to chemical language representation learning,…

Chemical Physics · Physics 2024-08-06 Jun-Hyung Park , Yeachan Kim , Mingyu Lee , Hyuntae Park , SangKeun Lee

High-dimensional data are commonly seen in modern statistical applications, variable selection methods play indispensable roles in identifying the critical features for scientific discoveries. Traditional best subset selection methods are…

Methodology · Statistics 2022-12-29 Tianzhou Ma , Hongjie Ke , Zhao Ren

In semi-supervised learning, methods that rely on confidence learning to generate pseudo-labels have been widely proposed. However, increasing research finds that when faced with noisy and biased data, the model's representation network is…

Computer Vision and Pattern Recognition · Computer Science 2024-04-29 Yanbiao Ma , Licheng Jiao , Fang Liu , Lingling Li , Shuyuan Yang , Xu Liu

Hyperdimensional computing (HDC) offers lightweight learning for energy-constrained devices by encoding data into high-dimensional vectors. However, its reliance on ultra-high dimensionality and static, randomly initialized hypervectors…

Machine Learning · Computer Science 2026-02-03 Hanne Dejonghe , Sam Leroux

Machine learning models differ in terms of accuracy, computational/memory complexity, training time, and adaptability among other characteristics. For example, neural networks (NNs) are well-known for their high accuracy due to the quality…

Machine Learning · Computer Science 2020-08-05 Mahdi Nazemi , Amirhossein Esmaili , Arash Fayyazi , Massoud Pedram

Epilepsy is a chronic neurological disorder with a significant prevalence. However, there is still no adequate technological support to enable epilepsy detection and continuous outpatient monitoring in everyday life. Hyperdimensional (HD)…

Neural and Evolutionary Computing · Computer Science 2024-04-30 Una Pale , Tomas Teijeiro , David Atienza
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