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E-variables are tools for retaining type-I error guarantee with optional stopping. We extend E-variables for sequential two-sample tests to general null hypotheses and anytime-valid confidence sequences. We provide implementations for…

Methodology · Statistics 2022-06-27 Rosanne Turner , Peter Grünwald

We develop and compare e-variables for testing whether $k$ samples of data are drawn from the same distribution, the alternative being that they come from different elements of an exponential family. We consider the GRO (growth-rate…

Methodology · Statistics 2024-01-09 Yunda Hao , Peter Grünwald , Tyron Lardy , Long Long , Reuben Adams

We provide a general condition under which e-variables in the form of a simple-vs.-simple likelihood ratio exist when the null hypothesis is a composite, multivariate exponential family. Such `simple' e-variables are easy to compute and…

Methodology · Statistics 2025-04-02 Peter Grünwald , Tyron Lardy , Yunda Hao , Shaul K. Bar-Lev , Martijn de Jong

E-variables are a relatively new approach for testing statistical hypotheses that has been experiencing major development during the last several years. In this paper we introduce the method of e-variable-approximability and use it to…

Information Theory · Computer Science 2026-03-04 Georgii Potapov , Yuri Kalnishkan

E-values have recently emerged as a robust and flexible alternative to p-values for hypothesis testing, especially under optional continuation, i.e., when additional data from further experiments are collected. In this work, we define…

Methodology · Statistics 2025-09-03 Francesca Giuffrida , Diego Garlaschelli , Peter Grünwald

E-variables are nonnegative random variables with expected value at most one under any distribution from a given null hypothesis. Every nonasymptotically valid test can be obtained by thresholding some e-variable. As such, e-variables arise…

Statistics Theory · Mathematics 2026-02-06 Martin Larsson , Aaditya Ramdas , Johannes Ruf

We develop the theory of hypothesis testing based on the e-value, a notion of evidence that, unlike the p-value, allows for effortlessly combining results from several studies in the common scenario where the decision to perform a new study…

Statistics Theory · Mathematics 2023-03-13 Peter Grünwald , Rianne de Heide , Wouter Koolen

Adaptive clinical trials rely on interim analyses, flexible stopping, and data-dependent design modifications that complicate statistical guarantees when fixed-horizon test statistics are repeatedly inspected or reused after adaptations.…

Methodology · Statistics 2026-02-09 Alexandra Sokolova , Vadim Sokolov

Conformal prediction is a powerful framework for distribution-free uncertainty quantification. The standard approach to conformal prediction relies on comparing the ranks of prediction scores: under exchangeability, the rank of a future…

Machine Learning · Statistics 2025-05-07 Etienne Gauthier , Francis Bach , Michael I. Jordan

Sequential decision making significantly speeds up research and is more cost-effective compared to fixed-n methods. We present a method for sequential decision making for stratified count data that retains Type-I error guarantee or false…

Methodology · Statistics 2023-02-23 Rosanne J. Turner , Peter D. Grünwald

Forecasting and forecast evaluation are inherently sequential tasks. Predictions are often issued on a regular basis, such as every hour, day, or month, and their quality is monitored continuously. However, the classical statistical tools…

Methodology · Statistics 2022-07-04 Sebastian Arnold , Alexander Henzi , Johanna F. Ziegel

Probability forecasts for binary events play a central role in many applications. Their quality is commonly assessed with proper scoring rules, which assign forecasts a numerical score such that a correct forecast achieves a minimal…

Methodology · Statistics 2022-07-04 Alexander Henzi , Johanna F. Ziegel

Hypothesis testing via e-variables can be framed as a sequential betting game, where a player each round picks an e-variable. A good player's strategy results in an effective statistical test that rejects the null hypothesis as soon as…

Statistics Theory · Mathematics 2025-05-30 Eugenio Clerico

We propose a sequential, anytime-valid method to test the conditional independence of a response $Y$ and a predictor $X$ given a random vector $Z$. The proposed test is based on e-statistics and test martingales, which generalize likelihood…

Methodology · Statistics 2023-02-22 Peter Grünwald , Alexander Henzi , Tyron Lardy

Categorical variables are of uttermost importance in biomedical research. When two of them are considered, it is often the case that one wants to test whether or not they are statistically dependent. We show weaknesses of classical methods…

The asymptotically optimal hypothesis testing problem with the general sources as the null and alternative hypotheses is studied under exponential-type error constraints on the first kind of error probability. Our fundamental philosophy in…

Probability · Mathematics 2007-05-23 Te Sun Han

We derive the unique e-values with optimal (relative) growth rate in the worst case for testing the mean of a bounded random variable, hereby contributing with the first application beyond the assumption of mutually absolutely continuous…

Statistics Theory · Mathematics 2026-01-19 Sebastian Arnold , Eugenio Clerico

We develop e-values and e-processes testing the null hypothesis that a distribution over nonnegative integers is monotone, and that a distribution over integers is unimodal given a certain mode. Our e-processes lead to tests of power one…

Statistics Theory · Mathematics 2026-04-23 Hongjian Wang , Aaditya Ramdas

We address the problem of testing conditional mean and conditional variance for non-stationary data. We build e-values and p-values for four types of non-parametric composite hypotheses with specified mean and variance as well as other…

Statistics Theory · Mathematics 2024-09-25 Yixuan Fan , Zhanyi Jiao , Ruodu Wang

The e-value is gaining traction as a robust alternative to p-values and Bayes factors for quantifying statistical evidence. e-values are a promising method for adaptive clinical trials due to their anytime-validity: e-values ensure type I…

Methodology · Statistics 2026-05-28 Stef Baas , Judith ter Schure , Joost van Rosmalen
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