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Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales. In this manuscript…

Molecular Networks · Quantitative Biology 2015-06-23 Jan Hasenauer , Nick Jagiella , Sabrina Hross , Fabian J. Theis

The network architecture of the human brain has become a feature of increasing interest to the neuroscientific community, largely because of its potential to illuminate human cognition, its variation over development and aging, and its…

Neurons and Cognition · Quantitative Biology 2016-11-07 Richard F. Betzel , Danielle S. Bassett

Multi-Context Systems are an expressive formalism to model (possibly) non-monotonic information exchange between heterogeneous knowledge bases. Such information exchange, however, often comes with unforseen side-effects leading to violation…

Artificial Intelligence · Computer Science 2015-03-19 Antonius Weinzierl

Multi-scale feedback systems, where information cycles through micro- and macro-scales leading to adaptation, are ubiquitous across domains, from animal societies and human organisations to electric grids and neural networks. Studies on the…

Systems and Control · Electrical Eng. & Systems 2021-06-04 Patricia Mellodge , Ada Diaconescu , Louisa Jane Di Felice

Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes to enable integrative multiscale simulations. Whereas traditional models focus on the structure…

Other Quantitative Biology · Quantitative Biology 2024-11-25 Eran Agmon

With the increasing interplay between experimental and computational approaches at multiple length scales, new research directions are emerging in materials science and computational mechanics. Such cooperative interactions find many…

Materials Science · Physics 2016-01-12 Rémi Dingreville , Richard A. Karnesky , Guillaume Puel , Jean-Hubert Schmitt

Multilevel modeling and simulation (M&S) is becoming increasingly relevant due to the benefits that this methodology offers. Multilevel models allow users to describe a system at multiple levels of detail. From one side, this can make…

Software Engineering · Computer Science 2024-03-26 Luca Serena , Moreno Marzolla , Gabriele D'Angelo , Stefano Ferretti

In most natural and engineered systems, a set of entities interact with each other in complicated patterns that can encompass multiple types of relationships, change in time, and include other types of complications. Such systems include…

Physics and Society · Physics 2014-08-28 Mikko Kivelä , Alexandre Arenas , Marc Barthelemy , James P. Gleeson , Yamir Moreno , Mason A. Porter

Biological systems, from a cell to the human brain, are inherently complex. A powerful representation of such systems, described by an intricate web of relationships across multiple scales, is provided by complex networks. Recently, several…

Quantitative Methods · Quantitative Biology 2018-02-06 M. De Domenico

When considering perceptions, the observation scale and resolution are closely related properties. There is consensus in considering resolution as the density of elementary pieces of information in a specified information space.…

Information Theory · Computer Science 2019-02-27 Gerardo Febres

Many conversational user interfaces facilitate linear conversations with turn-based dialogue, similar to face-to-face conversations between people. However, digital conversations can afford more than simple back-and-forth; they can be…

A common paradigm for scientific computing is distributed message-passing systems, and a common approach to these systems is to implement them across clusters of high-performance workstations. As multi-core architectures become increasingly…

Distributed, Parallel, and Cluster Computing · Computer Science 2012-05-01 Christine Task , Arun Chauhan

Multilayer networks represent systems in which there are several topological levels each one representing one kind of interaction or interdependency between the systems' elements. These networks have attracted a lot of attention recently…

Physics and Society · Physics 2015-04-22 Emanuele Cozzo , Guilherme Ferraz de Arruda , Francisco A. Rodrigues , Yamir Moreno

Understanding realistic complex systems requires confronting significant conceptual, theoretical and experimental limitations rooted in the persistence of views that originated in the mechanics of simple moving bodies. We define the…

Physics and Society · Physics 2024-03-06 Santiago Núñez-Corrales , Eric Jakobsson

Feedback is a most important concept in control systems, its main purpose is to deal with internal and/or external uncertainties in dynamical systems, by using the on-line observed information. Thus, a fundamental problem in control theory…

Optimization and Control · Mathematics 2007-05-23 Lei Guo

Living systems, particularly multicellular systems, often seem hopelessly complex. But recent studies have suggested that beneath this complexity, there may be unifying quantitative principles that we are only now starting to unravel. All…

Molecular Networks · Quantitative Biology 2016-03-01 Eduardo P. Olimpio , Diego R. Gomez-Alvarez , Hyun Youk

Self-organized pattern formation is vital for many biological processes. Reaction-diffusion models have advanced our understanding of how biological systems develop spatial structures, starting from homogeneity. However, biological…

At a continuous transition into a nonunique absorbing state, particle systems may exhibit nonuniversal critical behavior, in apparent violation of hyperscaling. We propose a generalized scaling theory for dynamic critical behavior at a…

Condensed Matter · Physics 2009-10-22 J. F. F. Mendes , Ronald Dickman , Malte Henkel , M. Ceu Marques

Multiple stable states - the coexistence of two or more distinct ecological configurations under identical environmental conditions - have attracted sustained interest in ecology, yet the field still lacks a unified framework connecting…

Populations and Evolution · Quantitative Biology 2026-05-08 Jennifer Paige , Denis D. Patterson , Alan Hastings

The new concept of multilevel network is introduced in order to embody some topological properties of complex systems with structures in the mesoscale which are not completely captured by the classical models. This new model, which…