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Precision measurements with quantum systems rely on our ability to trace the differences between experimental signals to variations in unknown physical parameters. In this Letter we derive the Fisher information and the ensuing Cramer-Rao…

Quantum Physics · Physics 2015-06-17 Søren Gammelmark , Klaus Mølmer

We present an innovative optical imaging system for measuring parameters of a small particle such as a macromolecule or nanoparticle at the quantum limit of sensitivity. In comparison to the conventional confocal interferometric scattering…

Quantum Physics · Physics 2025-07-14 Fabian Müller , Emre Köse , Alfred J. Meixner , Erik Schäffer , Daniel Braun

Single-molecule tracking is a powerful way to look at the dynamic organization of plasma membranes. However, there are some limitations to its use. For example, it was recently observed, using numerical simulation, that time-averaging…

Quantitative Methods · Quantitative Biology 2009-11-13 Nicolas Destainville , Laurence Salome

Bounding the optimal precision in parameter estimation tasks is of central importance for technological applications. In the regime of a small number of measurements, or that of low signal-to-noise ratios, the meaning of common frequentist…

Quantum Physics · Physics 2024-02-23 Valentin Gebhart , Manuel Gessner , Augusto Smerzi

Context. The best precision that can be achieved to estimate the location of a stellar-like object is a topic of permanent interest in the astrometric community. Aims. We analyse bounds for the best position estimation of a stellar-like…

Instrumentation and Methods for Astrophysics · Physics 2016-10-26 Alex Echeverria , Jorge F. Silva , Rene A. Mendez , Marcos Orchard

In modern radar systems, precise target localization using azimuth and velocity estimation is paramount. Traditional unbiased estimation methods have utilized gradient descent algorithms to reach the theoretical limits of the Cramer Rao…

Signal Processing · Electrical Eng. & Systems 2024-04-24 Shyam Venkatasubramanian , Sandeep Gogineni , Bosung Kang , Muralidhar Rangaswamy

Precise manipulation of single molecules has already led to remarkable insights in physics, chemistry, biology and medicine. However, widespread adoption of single-molecule techniques has been impeded by equipment cost and the laborious…

Biological Physics · Physics 2015-05-14 Ken Halvorsen , Wesley P. Wong

Cells rely on focal adhesions (FAs) to carry out a variety of important tasks, including motion, environmental sensing, and adhesion to the extracellular matrix. Although attaining a fundamental characterization of FAs is a compelling goal,…

A key limitation of sampling algorithms for approximate inference is that it is difficult to quantify their approximation error. Widely used sampling schemes, such as sequential importance sampling with resampling and Metropolis-Hastings,…

Artificial Intelligence · Computer Science 2017-05-09 Marco F. Cusumano-Towner , Vikash K. Mansinghka

In the next generation of wireless systems, Massive MIMO offers high angular resolution for localization. By virtue of large number of antennas, the Angle of Arrival (AoA) of User Terminals (UTs) can be estimated with high accuracy.…

Information Theory · Computer Science 2021-03-11 Masoud Arash , Hamed Mirghasemi , Ivan Stupia , Luc Vandendorpe

The quantum Cram\'er-Rao bound sets a fundamental limit on the accuracy of unbiased parameter estimation in quantum systems, relating the uncertainty in determining a parameter to the inverse of the quantum Fisher information. We…

This work is devoted to solve the problem of estimating the carrier frequency offset, phase offset, amplitude, and SNR between two mmWave transceivers. The Cram\'{e}r-Rao Lower Bound (CRLB) for the different parameters is provided first, as…

Information Theory · Computer Science 2017-12-19 Javier Rodríguez-Fernández , Nuria González-Prelcic , Robert W. Heath

A new approach is proposed, namely CSSF MIMO radar, which applies the technique of step frequency (SF) to compressive sensing (CS) based multi-input multi-output (MIMO) radar. The proposed approach enables high resolution range, angle and…

Information Theory · Computer Science 2015-03-17 Yao Yu , Athina P. Petropulu , H. Vincent Poor

This paper derives a general expression for the Cram\'er-Rao bound (CRB) of wireless localization algorithms using range measurements subject to bias corruption. Specifically, the a priori knowledge about which range measurements are…

Information Theory · Computer Science 2011-11-10 Tao Wang

This paper addresses the real-time state estimation problem for dynamic systems while protecting exogenous inputs against adversaries, who may be honest-but-curious third parties or external eavesdroppers. The Cram\'er-Rao lower bound…

Systems and Control · Electrical Eng. & Systems 2025-12-10 Liping Guo , Jimin Wang , Yanlong Zhao , Ji-Feng Zhang

The expectation-maximization (EM) algorithm is an iterative computational method to calculate the maximum likelihood estimators (MLEs) from the sample data. It converts a complicated one-time calculation for the MLE of the incomplete data…

Computation · Statistics 2016-08-08 Lingyao Meng

In this article we consider Bayesian parameter inference associated to partially-observed stochastic processes that start from a set B0 and are stopped or killed at the first hitting time of a known set A. Such processes occur naturally…

Computation · Statistics 2012-01-19 Ajay Jasra , Nikolas Kantas

The Fisher information matrix (FIM) has long been of interest in statistics and other areas. It is widely used to measure the amount of information and calculate the lower bound for the variance for maximum likelihood estimation (MLE). In…

Information Theory · Computer Science 2015-06-19 Shenghan Guo

We establish a simple method to assess the quantum Fisher information required for resolving two incoherent point sources with an imaging system. The resulting Cram\'er-Rao bound shows that the standard Rayleigh limit can be surpassed by…

Quantum Physics · Physics 2016-06-28 Martin Paur , Bohumil Stoklasa , Zdenek Hradil , Luis L. Sanchez-Soto , Jaroslav Rehacek

The aim of this thesis is to develop a theoretical framework to study parameter estimation of quantum channels. We study the task of estimating unknown parameters encoded in a channel in the sequential setting. A sequential strategy is the…

Quantum Physics · Physics 2022-01-06 Vishal Katariya