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Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Despite the success of deep learning in speech recognition, multi-dialect speech recognition remains a difficult problem. Although dialect-specific acoustic models are known to perform well in general, they are not easy to maintain when…

Machine Learning · Computer Science 2022-05-09 Sanghyun Yoo , Inchul Song , Yoshua Bengio

Fusing structural-functional images of the brain has shown great potential to analyze the deterioration of Alzheimer's disease (AD). However, it is a big challenge to effectively fuse the correlated and complementary information from…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Qiankun Zuo , Junren Pan , Shuqiang Wang

Automatic detection and severity level classification of dysarthria directly from acoustic speech signals can be used as a tool in medical diagnosis. In this work, the pre-trained wav2vec 2.0 model is studied as a feature extractor to build…

Audio and Speech Processing · Electrical Eng. & Systems 2023-10-18 Farhad Javanmardi , Saska Tirronen , Manila Kodali , Sudarsana Reddy Kadiri , Paavo Alku

Early and accurate detection of Alzheimer's disease (AD) remains a major challenge in medical diagnosis due to its subtle onset and progressive nature. This research introduces an explainable ensemble learning Framework designed to classify…

Machine Learning · Computer Science 2026-03-06 Nishan Mitra

We present a framework to recognize Parkinson's disease (PD) through an English pangram utterance speech collected using a web application from diverse recording settings and environments, including participants' homes. Our dataset includes…

Comparing spoken segments is a central operation to speech processing. Traditional approaches in this area have favored frame-level dynamic programming algorithms, such as dynamic time warping, because they require no supervision, but they…

Computation and Language · Computer Science 2023-08-30 Shane Settle

Most of medical developments require the ability to identify samples that are anomalous with respect to a target group or control group, in the sense they could belong to a new, previously unseen class or are not class data. In this case…

Parkinson's Disease (PD) is a progressive neurodegenerative disorder that significantly impacts both motor and non-motor functions, including speech. Early and accurate recognition of PD through speech analysis can greatly enhance patient…

Numerical Analysis · Mathematics 2024-07-24 Niloofar Fadavi , Nazanin Fadavi

The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers. However, to…

Machine Learning · Computer Science 2021-09-28 Raphael Ronge , Kwangsik Nho , Christian Wachinger , Sebastian Pölsterl

We propose a novel framework for Alzheimer's disease (AD) detection using brain MRIs. The framework starts with a data augmentation method called Brain-Aware Replacements (BAR), which leverages a standard brain parcellation to replace…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Mehmet Saygın Seyfioğlu , Zixuan Liu , Pranav Kamath , Sadjyot Gangolli , Sheng Wang , Thomas Grabowski , Linda Shapiro

Over the years, activity sensing and recognition has been shown to play a key enabling role in a wide range of applications, from sustainability and human-computer interaction to health care. While many recognition tasks have traditionally…

Human-Computer Interaction · Computer Science 2019-04-09 Dawei Liang , Edison Thomaz

Early and accessible detection of Alzheimer's disease (AD) remains a major challenge, as current diagnostic methods often rely on costly and invasive biomarkers. Speech and language analysis has emerged as a promising non-invasive and…

Audio and Speech Processing · Electrical Eng. & Systems 2026-03-06 Franziska Braun , Christopher Witzl , Florian Hönig , Elmar Nöth , Tobias Bocklet , Korbinian Riedhammer

Alzheimers Disease AD is an acute neuro disease that degenerates the brain cells and thus leads to memory loss progressively. It is a fatal brain disease that mostly affects the elderly. It steers the decline of cognitive and biological…

Machine Learning · Computer Science 2023-04-20 Nair Bini Balakrishnan , P. S. Sreeja , Jisha Jose Panackal

Transfer learning has been widely utilized to mitigate the data scarcity problem in the field of Alzheimer's disease (AD). Conventional transfer learning relies on re-using models trained on AD-irrelevant tasks such as natural image…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Kai Tzu-iunn Ong , Hana Kim , Minjin Kim , Jinseong Jang , Beomseok Sohn , Yoon Seong Choi , Dosik Hwang , Seong Jae Hwang , Jinyoung Yeo

Speech contains both acoustic and linguistic patterns that reflect cognitive decline, and therefore models describing only one domain cannot fully capture such complexity. This study investigates how early fusion (EF) of speech and its…

Audio and Speech Processing · Electrical Eng. & Systems 2026-02-02 Krystof Novotny , Laureano Moro-Velázquez , Jiri Mekyska

Recent work has begun exploring neural acoustic word embeddings---fixed-dimensional vector representations of arbitrary-length speech segments corresponding to words. Such embeddings are applicable to speech retrieval and recognition tasks,…

Computation and Language · Computer Science 2017-03-14 Wanjia He , Weiran Wang , Karen Livescu

Detection of Alzheimer's Disease (AD) from neuroimaging data such as MRI through machine learning have been a subject of intense research in recent years. Recent success of deep learning in computer vision have progressed such research…

Computer Vision and Pattern Recognition · Computer Science 2017-12-01 Marcia Hon , Naimul Khan

Background:Cognitive assessments represent the most common clinical routine for the diagnosis of Alzheimer's Disease (AD). Given a large number of cognitive assessment tools and time-limited office visits, it is important to determine a…

Quantitative Methods · Quantitative Biology 2020-11-16 Bo Peng , Xiaohui Yao , Shannon L. Risacher , Andrew J. Saykin , Li Shen , Xia Ning

Accurately classifying accents and assessing accentedness in non-native speakers are both challenging tasks due to the complexity and diversity of accent and dialect variations. In this study, embeddings from advanced pre-trained language…

Audio and Speech Processing · Electrical Eng. & Systems 2023-10-18 Shahram Ghorbani , John H. L. Hansen
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