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Many biomedical studies collect high-dimensional medical imaging data to identify biomarkers for the detection, diagnosis, and treatment of human diseases. Consequently, it is crucial to develop accurate models that can predict a wide range…

Methodology · Statistics 2025-05-05 Yue Wang , Xiao Wang , Joseph G. Ibrahim , Hongtu Zhu

In this paper, we propose methods for functional predictor selection and the estimation of smooth functional coefficients simultaneously in a scalar-on-function regression problem under high-dimensional multivariate functional data setting.…

Methodology · Statistics 2022-05-04 Ali Mahzarnia , Jun Song

In this paper, we study a smoothness regularization method for a varying coefficient model based on sparse and irregularly sampled functional data which is contaminated with some measurement errors. We estimate the one-dimensional…

Methodology · Statistics 2017-11-28 Behdad Mostafaiy

Most brain disorders are very heterogeneous in terms of their underlying biology and developing analysis methods to model such heterogeneity is a major challenge. A promising approach is to use probabilistic regression methods to estimate…

Machine Learning · Statistics 2018-12-03 Seyed Mostafa Kia , Christian F. Beckmann , Andre F. Marquand

Scalar-on-image regression aims to investigate changes in a scalar response of interest based on high-dimensional imaging data. We propose a novel Bayesian nonparametric scalar-on-image regression model that utilises the spatial coordinates…

Methodology · Statistics 2022-06-23 Mica Teo Shu Xian , Sara Wade

In this article, we propose a novel spatial global-local spike-and-slab selection prior for image-on-scalar regression. We consider a Bayesian hierarchical Gaussian process model for image smoothing, that uses a flexible Inverse-Wishart…

Methodology · Statistics 2022-12-19 Zijian Zeng , Meng Li , Marina Vannucci

We present an extension of the functional data analysis framework for univariate functions to the analysis of surfaces: functions of two variables. The spatial spline regression (SSR) approach developed can be used to model surfaces that…

Methodology · Statistics 2013-06-17 Hien D. Nguyen , Geoffrey J. McLachlan , Ian A. Wood

We address the problem of survival regression modelling with multivariate responses and nonlinear covariate effects. Our model extends the proportional hazards model by introducing several weakly-parametric elements: the marginal baseline…

Methodology · Statistics 2025-10-16 Na Lei , Mark A. Wolters , Wenqing He

Traditional functional linear regression usually takes a one-dimensional functional predictor as input and estimates the continuous coefficient function. Modern applications often generate two-dimensional covariates, which become matrices…

Methodology · Statistics 2024-11-26 Dan Yang , Jianlong Shao , Haipeng Shen , Hongtu Zhu

Motivated by recent work studying massive imaging data in the neuroimaging literature, we propose multivariate varying coefficient models (MVCM) for modeling the relation between multiple functional responses and a set of covariates. We…

Statistics Theory · Mathematics 2013-02-19 Hongtu Zhu , Runze Li , Linglong Kong

The paper considers functional linear regression, where scalar responses $Y_1,...,Y_n$ are modeled in dependence of random functions $X_1,...,X_n$. We propose a smoothing splines estimator for the functional slope parameter based on a…

Statistics Theory · Mathematics 2009-02-26 Christophe Crambes , Alois Kneip , Pascal Sarda

Structured additive distributional regression models offer a versatile framework for estimating complete conditional distributions by relating all parameters of a parametric distribution to covariates. Although these models efficiently…

Methodology · Statistics 2023-11-14 Jana Kleinemeier , Nadja Klein

Local variable selection aims to test for the effect of covariates on an outcome within specific regions. We outline a challenge that arises in the presence of non-linear effects and model misspecification. Specifically, for common…

Methodology · Statistics 2024-08-02 David Rossell , Arnold Kisuk Kseung , Ignacio Saez , Michele Guindani

We develop a Fisher-consistent redescending robust estimator for the spatial scalar-on-function regression model, where a scalar response depends on both a functional predictor and a spatial autoregressive lag. Existing estimation…

Methodology · Statistics 2026-05-04 Muge Mutis , Ufuk Beyaztas , Han Lin Shang

We propose a flexible yet interpretable model for high-dimensional data with time-varying second order statistics, motivated and applied to functional neuroimaging data. Motivated by the neuroscience literature, we factorize the covariances…

Machine Learning · Statistics 2021-07-20 Katherine Tsai , Mladen Kolar , Oluwasanmi Koyejo

As a general and robust alternative to traditional mean regression models, quantile regression avoids the assumption of normally distributed errors, making it a versatile choice when modeling outcomes such as cognitive scores that typically…

Methodology · Statistics 2026-03-19 Rongke Lyu , Marina Vannucci , Suprateek Kundu

We consider the joint inference of regression coefficients and the inverse covariance matrix for covariates in high-dimensional probit regression, where the predictors are both relevant to the binary response and functionally related to one…

Methodology · Statistics 2022-03-15 Xuan Cao , Kyoungjae Lee

The crossed random effects model is widely used, finding applications in various fields such as longitudinal studies, e-commerce, and recommender systems, among others. However, these models encounter scalability challenges, as the…

Methodology · Statistics 2025-10-21 Disha Ghandwani , Swarnadip Ghosh , Trevor Hastie , Art B. Owen

Recent evidence has shown that structural magnetic resonance imaging (MRI) is an effective tool for Alzheimer's disease (AD) prediction and diagnosis. While traditional MRI-based diagnosis uses images acquired at a single time point, a…

Applications · Statistics 2021-11-02 Xiaowu Dai

Starting from a variational formulation, we present a model for image segmentation that employs both region statistics and edge information. This combination allows for improved flexibility, making the proposed model suitable to process a…

Analysis of PDEs · Mathematics 2019-10-15 Carlos M. Paniagua Mejia