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In meta-analytic modeling, the functional relationship between a primary and surrogate endpoint is estimated using summary data from a set of completed clinical trials. Parameters in the meta-analytic model are used to assess the quality of…

Methodology · Statistics 2025-08-07 James P. Long , Abhishikta Roy , Ehsan Irajizad , Kim-Anh Do , Yu Shen

The method of surrogate data provides a framework for testing observed data against a hierarchy of alternative hypotheses. The aim of applying this method is to exclude the possibility that the data are consistent with simple linear…

Chaotic Dynamics · Physics 2007-05-23 Xiaodong Luo , Jie Zhang , Junfeng Sun , Michael Small , Irene Moroz

Surrogate models provide compact relations between user-defined input parameters and output quantities of interest, enabling the efficient evaluation of complex parametric systems in many-query settings. Such capabilities are essential in a…

Numerical Analysis · Mathematics 2026-03-16 Matteo Giacomini , Pedro Díez

Randomized experimentation (also known as A/B testing or bucket testing) is widely used in the internet industry to measure the metric impact obtained by different treatment variants. A/B tests identify the treatment variant showing the…

We propose a new approach for building recommender systems by adapting surrogate-assisted interactive genetic algorithms. A pool of user-evaluated items is used to construct an approximative model which serves as a surrogate fitness…

Neural and Evolutionary Computing · Computer Science 2019-08-09 Thomas Gabor , Philipp Altmann

Controlled experiments (A/B tests or randomized field experiments) are the de facto standard to make data-driven decisions when implementing changes and observing customer responses. The methodology to analyze such experiments should be…

Applications · Statistics 2020-03-06 Shafi Kamalbasha , Manuel J. A. Eugster

When developing a new networking algorithm, it is established practice to run a randomized experiment, or A/B test, to evaluate its performance. In an A/B test, traffic is randomly allocated between a treatment group, which uses the new…

Networking and Internet Architecture · Computer Science 2021-10-04 Bruce Spang , Veronica Hannan , Shravya Kunamalla , Te-Yuan Huang , Nick McKeown , Ramesh Johari

Online A/B testing is widely used in the internet industry to inform decisions on new feature roll-outs. For online marketplaces (such as advertising markets), standard approaches to A/B testing may lead to biased results when buyers…

A common dilemma encountered by many upon implementing an optimization method or experiment, whether it be a reinforcement learning algorithm, or A/B testing, is deciding on what metric to optimize for. Very often short-term metrics, which…

Applications · Statistics 2019-06-17 Yoni Schamroth , Liron Gat Kahlon , Boris Rabinovich , David Steinberg

Adaptive designs are increasingly used in clinical trials and online experiments to improve participant outcomes by dynamically updating treatment allocation as data accumulate. In practice, experimenters often consider multiple candidate…

Methodology · Statistics 2026-04-08 Wenxin Zhang , Aaron Hudson , Maya Petersen , Mark van der Laan

Surrogate markers are most commonly studied within the context of randomized clinical trials. However, the need for alternative outcomes extends beyond these settings and may be more pronounced in real-world public health and social science…

Methodology · Statistics 2025-04-23 Rebecca Knowlton , Layla Parast

A/B test, a simple type of controlled experiment, refers to the statistical procedure of experimenting to compare two treatments applied to test subjects. For example, many IT companies frequently conduct A/B tests on their users who are…

Methodology · Statistics 2026-05-12 Qiong Zhang , Lulu Kang

A challenge that machine learning practitioners in the industry face is the task of selecting the best model to deploy in production. As a model is often an intermediate component of a production system, online controlled experiments such…

Machine Learning · Statistics 2021-05-31 Zhenwen Dai , Praveen Chandar , Ghazal Fazelnia , Ben Carterette , Mounia Lalmas-Roelleke

A/B testing methodology is generally performed by private companies to increase user engagement and satisfaction about online features. Their usage is far from being transparent and may undermine user autonomy (e.g. polarizing individual…

Social and Information Networks · Computer Science 2024-05-03 Matteo Ottaviani , Stefan M. Herzog , Pietro Leonardo Nickl , Philipp Lorenz-Spreen

In the past decade, the technology industry has adopted online randomized controlled experiments (a.k.a. A/B testing) to guide product development and make business decisions. In practice, A/B tests are often implemented with increasing…

Methodology · Statistics 2023-03-27 Kevin Han , Shuangning Li , Jialiang Mao , Han Wu

A/B testing, or controlled experiments, is the gold standard approach to causally compare the performance of algorithms on online platforms. However, conventional Bernoulli randomization in A/B testing faces many challenges such as…

Machine Learning · Computer Science 2023-02-13 Yongkang Guo , Yuan Yuan , Jinshan Zhang , Yuqing Kong , Zhihua Zhu , Zheng Cai

A/B testing, also known as controlled experiment, bucket testing or splitting testing, has been widely used for evaluating a new feature, service or product in the data-driven decision processes of online websites. The goal of A/B testing…

Applications · Statistics 2016-10-26 Bai Jiang , Xiaolin Shi , Hongwei Shang , Zhigeng Geng , Alyssa Glass

We study ratio metrics in A/B testing at the presence of correlation among observations coming from the same user and provides practical guidance especially when two metrics contradict each other. We propose new estimating methods to…

Applications · Statistics 2020-07-24 Keyu Nie , Yinfei Kong , Ted Tao Yuan , Pauline Berry Burke

The primary benefit of identifying a valid surrogate marker is the ability to use it in a future trial to test for a treatment effect with shorter follow-up time or less cost. However, previous work has demonstrated potential heterogeneity…

Methodology · Statistics 2022-09-20 Layla Parast , Tianxi Cai , Lu Tian

Candidate binary endpoints are often considered as surrogates for time-to-event (TTE) clinical endpoints, primarily because they can be assessed at earlier time points. To be submitted for regulatory approval candidate binary endpoints need…

Applications · Statistics 2026-03-23 Renee Y. Ge , Azadeh Shohoudi , Malini Iyengar , Quefeng Li , Judy Li