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This work shows promising results using multiple instance learning on salivary gland tumours in classifying cancers on whole slide images. Utilising CTransPath as a patch-level feature extractor and CLAM as a feature aggregator, an F1 score…

Image and Video Processing · Electrical Eng. & Systems 2024-08-23 John Charlton , Ibrahim Alsanie , Syed Ali Khurram

Weakly supervised instance labeling using only image-level labels, in lieu of expensive fine-grained pixel annotations, is crucial in several applications including medical image analysis. In contrast to conventional instance segmentation…

Computer Vision and Pattern Recognition · Computer Science 2019-07-31 Jayaraman J. Thiagarajan , Satyananda Kashyap , Alexandros Karagyris

Convolutional neural networks (CNN) have achieved state of the art performance on both classification and segmentation tasks. Applying CNNs to microscopy images is challenging due to the lack of datasets labeled at the single cell level. We…

Computer Vision and Pattern Recognition · Computer Science 2017-05-25 Oren Z. Kraus , Lei Jimmy Ba , Brendan Frey

Medical images differ from natural images in significantly higher resolutions and smaller regions of interest. Because of these differences, neural network architectures that work well for natural images might not be applicable to medical…

Computer Vision and Pattern Recognition · Computer Science 2020-02-19 Yiqiu Shen , Nan Wu , Jason Phang , Jungkyu Park , Kangning Liu , Sudarshini Tyagi , Laura Heacock , S. Gene Kim , Linda Moy , Kyunghyun Cho , Krzysztof J. Geras

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). Existing approaches typically rely on frozen pre-trained models to extract instance features, neglecting the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Yi Lin , Zhengjie Zhu , Kwang-Ting Cheng , Hao Chen

Machine learning models have become integral to many fields, but their reliability, defined as producing dependable, trustworthy, and domain-consistent predictions, remains a critical concern. Multiple Instance Learning (MIL) models…

Computer Vision and Pattern Recognition · Computer Science 2025-12-10 Hassan Keshvarikhojasteh , Marc Aubreville , Christof A. Bertram , Josien P. W. Pluim , Mitko Veta

The Multiple Instance Learning (MIL) paradigm is attracting plenty of attention in medical imaging classification, where labeled data is scarce. MIL methods cast medical images as bags of instances (e.g. patches in whole slide images, or…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Francisco M. Castro-Macías , Pablo Morales-Álvarez , Yunan Wu , Rafael Molina , Aggelos K. Katsaggelos

Multi-instance learning (MIL) is a widely-applied technique in practical applications that involve complex data structures. MIL can be broadly categorized into two types: traditional methods and those based on deep learning. These…

Artificial Intelligence · Computer Science 2023-04-25 Yu-Xuan Zhang , Zhengchun Zhou , Xingxing He , Avik Ranjan Adhikary , Bapi Dutta

Predicting breast cancer recurrence risk is a critical clinical challenge. This study investigates the potential of computational pathology to stratify patients using deep learning on routine Hematoxylin and Eosin (H&E) stained whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Jinqiu Chen , Huyan Xu

Multi-instance learning (MIL) deals with tasks where data is represented by a set of bags and each bag is described by a set of instances. Unlike standard supervised learning, only the bag labels are observed whereas the label for each…

Machine Learning · Computer Science 2021-04-27 Weijia Zhang , Jiuyong Li , Lin Liu

Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes…

Computer Vision and Pattern Recognition · Computer Science 2022-07-20 Marvin Teichmann , Andre Aichert , Hanibal Bohnenberger , Philipp Ströbel , Tobias Heimann

Multi-label image classification presents a challenging task in many domains, including computer vision and medical imaging. Recent advancements have introduced graph-based and transformer-based methods to improve performance and capture…

Computer Vision and Pattern Recognition · Computer Science 2024-04-15 Ahmad Sajedi , Samir Khaki , Yuri A. Lawryshyn , Konstantinos N. Plataniotis

When applying multi-instance learning (MIL) to make predictions for bags of instances, the prediction accuracy of an instance often depends on not only the instance itself but also its context in the corresponding bag. From the viewpoint of…

Computer Vision and Pattern Recognition · Computer Science 2022-04-25 Tiancheng Lin , Hongteng Xu , Canqian Yang , Yi Xu

Multiple Instance Learning (MIL) has emerged as a promising paradigm for Whole Slide Image (WSI) diagnosis, offering effective learning with limited annotations. However, existing MIL frameworks overlook diagnostic priorities and fail to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Sungrae Hong , Jiwon Jeong , Jisu Shin , Donghee Han , Sol Lee , Kyungeun Kim , Mun Yong Yi

Multi-instance learning (MIL) is a form of weakly supervised learning where a single class label is assigned to a bag of instances while the instance-level labels are not available. Training classifiers to accurately determine the bag label…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Bin Li , Kevin W. Eliceiri

The rapid on-site evaluation (ROSE) technique can significantly ac-celerate the diagnostic workflow of pancreatic cancer by immediately analyzing the fast-stained cytopathological images with on-site pathologists. Computer-aided diagnosis…

Image and Video Processing · Electrical Eng. & Systems 2022-06-08 Tianyi Zhang , Youdan Feng , Yunlu Feng , Guanglei Zhang

Advances in medical imaging and deep learning have propelled progress in whole slide image (WSI) analysis, with multiple instance learning (MIL) showing promise for efficient and accurate diagnostics. However, conventional MIL models often…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Xianrui Li , Yufei Cui , Jun Li , Antoni B. Chan

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for…

Computer Vision and Pattern Recognition · Computer Science 2024-05-06 Diogo J. Araújo , M. Rita Verdelho , Alceu Bissoto , Jacinto C. Nascimento , Carlos Santiago , Catarina Barata

Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Enhui Chai , Sicheng Chen , Tianyi Zhang , Chad Wong , Kecheng Huang , Zeyu Liu , Fei Xia

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh