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Optical imaging of blood flow yields critical functional insights into the circulatory system, but its clinical implementation has typically been limited to shallow depths (~1 millimeter) due to light scattering in biological tissue. Here,…
Recently developed methods for rapid continuous volumetric two-photon microscopy facilitate the observation of neuronal activity in hundreds of individual neurons and changes in blood flow in adjacent blood vessels across a large volume of…
Dynamic and precise measurement of cerebral blood flow velocity is crucial in neuroscience and the diagnosis of cerebrovascular diseases. Traditional color Doppler ultrasound can only measure the velocity component along the ultrasound…
We introduce a velocimetry technique based on the Doppler-shift of surface waves propagating between an emitter and a receiver. In the limit of scale separation between the wavelength and the scale of the flow, we derive the direct…
Continuously measured arterial blood velocity can provide insight into physiological parameters and potential disease states. The efficient and effective description of the temporal profiles of arterial velocity is crucial for both clinical…
We report on wide-field imaging of pulsatile microvascular blood flow in the exposed cerebral cortex of a mouse by holographic interferometry. We recorded interferograms of laser light backscattered by the tissue, beating against an…
We combine confocal imaging, microfluidics and image analysis to record 3D-images of cells in flow. This enables us to recover the full 3D representation of several hundred living cells per minute. Whereas 3D confocal imaging has thus far…
We report a diffuse Maxwellian illumination scheme for wide-field retinal laser Doppler holography. Inserting an engineered diffuser in the illumination arm transforms a spatially concentrated near-infrared laser focus into an angularly…
We introduce a new method, (Doppler Velocity Reconstruction or DoVeR), for reconstructing two-component velocity fields from color Doppler scans. DoVeR employs the streamfunction-vorticity equation, which satisfies mass conservation while…
Diabetic retinopathy is the basic reason for visual deficiency. This paper introduces a programmed strategy to identify and dispense with the blood vessels. The location of the blood vessels is the fundamental stride in the discovery of…
Non-invasive imaging of deep blood vessels for mapping hemodynamics remains an open quest in biomedical optical imaging. Although pure optical imaging techniques offer rich optical contrast of blood and have been reported to measure blood…
Research and medicine rely on non-invasive optical techniques to image living tissue with high resolution in space and time. But so far a single data acquisition could not provide entirely diffraction-limited tomographic volumes of rapidly…
The appearance and structure of blood vessels in retinal images have an important role in diagnosis of diseases. This paper proposes a method for automatic retinal vessel segmentation. In this work, a novel preprocessing based on local…
Optical coherence tomography angiography (OCTA) can visualize vasculature structures, but provides limited information about the blood flow speeds. Here, we present a second generation variable interscan time analysis (VISTA) OCTA, which…
Optical coherence tomography angiography (OCTA) is an imaging technique that allows for non-invasive investigation of the microvasculature in the retina. OCTA uses laser light reflectance to measure moving blood cells. Hereby, it visualizes…
The reliable segmentation of retinal vasculature can provide the means to diagnose and monitor the progression of a variety of diseases affecting the blood vessel network, including diabetes and hypertension. We leverage the power of…
We present recent advances in the instrumentation and analysis methods for quantitative imaging of concentrated colloidal suspensions under flow. After a brief review of colloidal imaging, we describe various flow geometries for two and and…
Optical coherence tomography angiography (OCTA) is a novel noninvasive imaging modality for visualization of retinal blood flow in the human retina. Using specific OCTA imaging biomarkers for the identification of pathologies, automated…
We report on the direct measurements of fluid flow vorticity using a spatially shaped beam with a superposition of Laguerre-Gaussian modes that reports on the rotational Doppler shift from microparticles intersecting the beam focus.…
Heterodyne Holography is a variant of Digital Holography, where the optical frequencies of signal and reference arms can be freely adjusted by acousto-optic modulators. Heterodyne Holography is an extremely versatile and reliable…