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We predict the Fried physical frailty phenotype health deficits (FPFP5: slow gait, weakness, weight loss, low activity, and exhaustion) using two measures of frailty: frailty index (FI) or frailty phenotype (FP). The FP theorizes that the…

Quantitative Methods · Quantitative Biology 2025-01-07 Glen Pridham , Kenneth Rockwood , Andrew Rutenberg

Principal component analysis (PCA) is a key tool in the field of data dimensionality reduction that is useful for various data science problems. However, many applications involve heterogeneous data that varies in quality due to noise…

Machine Learning · Statistics 2023-11-14 Javier Salazar Cavazos , Jeffrey A. Fessler , Laura Balzano

Functional data analysis, which handles data arising from curves, surfaces, volumes, manifolds and beyond in a variety of scientific fields, is a rapidly developing area in modern statistics and data science in the recent decades. The…

Methodology · Statistics 2020-08-21 Xiaoke Zhang , Wu Xue , Qiyue Wang

Physical activity energy expenditure (PAEE) can be measured from breath-by-breath respiratory data, which can serve as a reference. Alternatively, PAEE can be predicted from the body movements, which can be measured and estimated with…

Machine Learning · Computer Science 2025-07-28 Shuhao Que , Remco Poelarends , Peter Veltink , Miriam Vollenbroek-Hutten , Ying Wang

Functional principal component analysis has been shown to be invaluable for revealing variation modes of longitudinal outcomes, which serves as important building blocks for forecasting and model building. Decades of research have advanced…

Methodology · Statistics 2024-10-07 Peijun Sang , Dehan Kong , Shu Yang

Physical activity is disrupted in many psychiatric disorders. Advances in everyday technologies (e.g. accelerometers in smart phones) opens exciting possibilities for non-intrusive acquisition of activity data. Successful exploitation of…

Quantitative Methods · Quantitative Biology 2016-12-19 Justin J. Chapman , James A. Roberts , Vinh T. Nguyen , Michael Breakspear

Multivariate functional principal component analysis (MFPCA) is a powerful dimension reduction technique for analyzing multiple functional variables simultaneously. However, existing MFPCA methods assume that all functional observations are…

In this study, we utilized statistical analysis and machine learning methods to examine whether rehabilitation exercises can improve patients post-stroke functional abilities, as well as forecast the improvement in functional abilities. Our…

Principal component analysis (PCA) frequently suffers from the disturbance of outliers and thus a spectrum of robust extensions and variations of PCA have been developed. However, existing extensions of PCA treat all samples equally even…

Machine Learning · Computer Science 2021-03-23 Rui Zhang , Hongyuan Zhang , Xuelong Li

Traditional Functional Principal Component Analysis typically focuses on densely observed univariate functional data, yet many applications, particularly in longitudinal studies, involve multivariate functional data observed sparsely and…

Methodology · Statistics 2026-03-23 Uche Mbaka , Michelle Carey

Through the quantification of physical activity energy expenditure (PAEE), health care monitoring has the potential to stimulate vital and healthy ageing, inducing behavioural changes in older people and linking these to personal health…

Signal Processing · Electrical Eng. & Systems 2022-01-12 Stylianos Paraschiakos , Cláudio Rebelo de Sá , Jeremiah Okai , Eline P. Slagboom , Marian Beekman , Arno Knobbe

Timely implementation of interventions to slow cognitive decline among older adults requires accurate monitoring to detect changes in cognitive function. Data gathered using wearable devices that can continuously monitor factors known to be…

Signal Processing · Electrical Eng. & Systems 2024-03-26 Collin Sakal , Tingyou Li , Juan Li , Xinyue Li

Factor analysis (FA) is a statistical tool for studying how observed variables with some mutual dependences can be expressed as functions of mutually independent unobserved factors, and it is widely applied throughout the psychological,…

Machine Learning · Statistics 2023-06-01 Alex Markham , Mingyu Liu , Bryon Aragam , Liam Solus

Accelerometer measurements are the prime type of sensor information most think of when seeking to measure physical activity. On the market, there are many fitness measuring devices which aim to track calories burned and steps counted…

Machine Learning · Computer Science 2017-04-14 Kevin M. Amaral , Ping Chen , Scott Crouter , Wei Ding

We present a new method based on Functional Data Analysis (FDA) for detecting associations between one or more scalar covariates and a longitudinal response, while correcting for other variables. Our methods exploit the temporal structure…

Applications · Statistics 2014-04-30 Matthew Reimherr , Dan Nicolae

We consider the problem of estimating multiple principal components using the recently-proposed Sparse and Functional Principal Components Analysis (SFPCA) estimator. We first propose an extension of SFPCA which estimates several principal…

Machine Learning · Statistics 2020-12-10 Michael Weylandt

Accelerometry data has been widely used to measure activity and the circadian rhythm of individuals across the health sciences, in particular with people with advanced dementia. Modern accelerometers can record continuous observations on a…

Parkinson's Disease (PD) is characterized by disorders in motor function such as freezing of gait, rest tremor, rigidity, and slowed and hyposcaled movements. Medication with dopaminergic medication may alleviate those motor symptoms,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-09 Terry Taewoong Um , Franz Michael Josef Pfister , Daniel Christian Pichler , Satoshi Endo , Muriel Lang , Sandra Hirche , Urban Fietzek , Dana Kulić

The analysis of multivariate functional curves has the potential to yield important scientific discoveries in domains such as healthcare, medicine, economics and social sciences. However, it is common for real-world settings to present…

Methodology · Statistics 2024-07-23 Tui Nolan , Sylvia Richardson , Hélène Ruffieux

This manuscript provides step-by-step instructions for implementing Bayesian functional regression models using Stan. Extensive simulations indicate that the inferential performance of the methods is comparable to that of state-of-the-art…

Methodology · Statistics 2026-02-27 Ziren Jiang , Ciprian Crainiceanu , Erjia Cui
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