Related papers: Modeling of cellular response after FLASH irradiat…
Recent results from animal irradiation studies have rekindled interest in the potential of ultra-high dose rate irradiation (also known as FLASH) for reducing normal tissue toxicity. However, despite mounting evidence of a "FLASH effect", a…
Objective: Radiolytic oxygen depletion (ROD) may play a role in the sparing of cells irradiated with ultra-high dose rates. Different methods have been used to quantify the effect of ROD during FLASH irradiation on cell survival, typically…
It has been postulated that the delivery of radiotherapy at ultra-high dose rates ("FLASH") reduces normal tissue toxicities by depleting them of oxygen. The fraction of normal tissue and cancer cells surviving radiotherapy depends on dose…
FLASH radiation has been reported to efficiently suppress tumor growth while sparing normal tissue, however, the mechanism of the differential tissue sparing effect is still not known. Oxygen has long been known to profoundly impact…
Background and purpose: Recent observations in animal models show that ultra-high dose rate ("FLASH") radiation treatment significantly reduces normal tissue toxicity maintaining an equivalent tumor control. The dependence of this "FLASH"…
We present a first-principles molecular dynamics (MD) simulation and expound upon a mechanism of oxygen depletion hypothesis to explain the mitigation of normal tissue injury observed in ultra-high-dose-rate (UHDR) FLASH radiotherapy. We…
FLASH radiotherapy (FLASH-RT) has shown the potential to spare normal tissue while seemingly maintaining the effectiveness of conventional radiotherapy (CONV-RT). It has been suggested that the protective effect arises from the radiolytic…
Background: Experiments have reported low normal tissue toxicities during FLASH radiation, but the mechanism has not been elaborated. Several hypotheses have been proposed to explain the mechanism. The oxygen depletion hypothesis has been…
Objective: This study aims to investigate the influence of organ architecture (specifically the distinction between serial and parallel tissue) on the protective FLASH effect when organs are irradiated with inhomogeneous dose distributions.…
Cancer treatment with radiotherapy aims to kill tumor cells and spare healthy tissue.Thus,the experimentally observed sparing of healthy tissue by the FLASH effect during irradiations with ultra-high dose rates (UHDR) enables clinicians to…
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. However, the physical conditions triggering the FLASH sparing…
Clinical applications of FLASH radiotherapy require formulas to describe how the FLASH radiation features and other related factors determine the FLASH effect. Mathematical analysis of the models can connect the theoretical hypotheses with…
FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy by delivering doses with ultra-high dose rates. FLASH-RT has the ability to suppress tumor growth while sparing normal tissues, known as the FLASH effect. Although FLASH effect…
Purpose: To investigate experimentally, if FLASH irradiation depletes oxygen within water for different radiation types such as photons, protons and carbon ions. Methods: This study presents measurements of the oxygen consumption in sealed,…
The differential sparing of normal tissues relative to tumor control observed at ultra-high dose rates, referred to as the FLASH effect, has recently gained considerable attention. The therapeutic advantages of FLASH radiotherapy are…
Objective: While FLASH radiotherapy is recognized for short-term normal tissue sparing, its durability in late-responding organs remains uncertain, limiting clinical adoption. With its clinical importance and steep dose-response, the spinal…
Radiation chemistry of model systems irradiated with ultra-high dose-rates (UHDR) is key to obtain a mechanistic understanding of the sparing of healthy tissue, which is called the FLASH effect. It is envisioned to be used for efficient…
Purpose: This study aims to investigate the impact of the beam temporal profile on the radical dynamics and inter-track interactions of FLASH radiotherapy, supporting parameter optimization for the equipment development and clinical…
Purpose: Our aim was to elucidate the critical factors responsible for inducing the FLASH effect, focusing on the role of free radicals through simulation and experimental approaches. Methods and Materials: The whole abdomen of C57BL/6 mice…
The differences in H2O2 production between conventional (CONV) and ultra-high dose rate (UHDR) irradiations in water radiolysis are still not fully understood. The lower levels of this radiolytic species, as a critical end product of water…