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The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

The ability to explain the prediction of deep learning models to end-users is an important feature to leverage the power of artificial intelligence (AI) for the medical decision-making process, which is usually considered non-transparent…

Computer Vision and Pattern Recognition · Computer Science 2023-03-09 Truong Thanh Hung Nguyen , Van Binh Truong , Vo Thanh Khang Nguyen , Quoc Hung Cao , Quoc Khanh Nguyen

Stochastic processes provide a mathematically elegant way model complex data. In theory, they provide flexible priors over function classes that can encode a wide range of interesting assumptions. In practice, however, efficient inference…

Machine Learning · Computer Science 2022-09-15 Swapnil Mishra , Seth Flaxman , Tresnia Berah , Harrison Zhu , Mikko Pakkanen , Samir Bhatt

Variational autoencoders (VAEs) are widely used deep generative models capable of learning unsupervised latent representations of data. Such representations are often difficult to interpret or control. We consider the problem of…

Machine Learning · Computer Science 2018-12-18 Jack Klys , Jake Snell , Richard Zemel

Explainable artificial intelligence (XAI) has become increasingly important in biomedical image analysis to promote transparency, trust, and clinical adoption of DL models. While several surveys have reviewed XAI techniques, they often lack…

Computer Vision and Pattern Recognition · Computer Science 2025-07-11 Getamesay Haile Dagnaw , Yanming Zhu , Muhammad Hassan Maqsood , Wencheng Yang , Xingshuai Dong , Xuefei Yin , Alan Wee-Chung Liew

Interpretability in machine learning models is important in high-stakes decisions, such as whether to order a biopsy based on a mammographic exam. Mammography poses important challenges that are not present in other computer vision tasks:…

Machine Learning · Computer Science 2021-03-24 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

Framing the investigation of diverse cancers as a machine learning problem has recently shown significant potential in multi-omics analysis and cancer research. Empowering these successful machine learning models are the high-quality…

Genomics · Quantitative Biology 2025-06-17 Ziwei Yang , Rikuto Kotoge , Xihao Piao , Zheng Chen , Lingwei Zhu , Peng Gao , Yasuko Matsubara , Yasushi Sakurai , Jimeng Sun

In this tutorial, we explore Variational Autoencoders (VAEs), an essential framework for unsupervised learning, particularly suited for high-dimensional datasets such as neuroimaging. By integrating deep learning with Bayesian inference,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-15 C. Vázquez-García , F. J. Martínez-Murcia , F. Segovia Román , Juan M. Górriz Sáez

Learning compact and interpretable representations of data is a critical challenge in scientific image analysis. Here, we introduce Affinity-VAE, a generative model that enables us to impose our scientific intuition about the similarity of…

The need for interpretable models has fostered the development of self-explainable classifiers. Prior approaches are either based on multi-stage optimization schemes, impacting the predictive performance of the model, or produce…

The extensive utilization of biometric authentication systems have emanated attackers / imposters to forge user identity based on morphed images. In this attack, a synthetic image is produced and merged with genuine. Next, the resultant…

Computer Vision and Pattern Recognition · Computer Science 2023-05-01 Rudresh Dwivedi , Ritesh Kumar , Deepak Chopra , Pranay Kothari , Manjot Singh

As machine learning systems increasingly inform critical decisions, the need for human-understandable explanations grows. Current evaluations of Explainable AI (XAI) often prioritize technical fidelity over cognitive accessibility which…

Human-Computer Interaction · Computer Science 2025-09-23 Tobias Labarta , Nhi Hoang , Katharina Weitz , Wojciech Samek , Sebastian Lapuschkin , Leander Weber

Many Machine Learning algorithms, such as deep neural networks, have long been criticized for being "black-boxes"-a kind of models unable to provide how it arrive at a decision without further efforts to interpret. This problem has raised…

Machine Learning · Statistics 2019-07-04 Yihuang Kang , I-Ling Cheng , Wenjui Mao , Bowen Kuo , Pei-Ju Lee

Learning interpretable representations of data remains a central challenge in deep learning. When training a deep generative model, the observed data are often associated with certain categorical labels, and, in parallel with learning to…

Machine Learning · Computer Science 2019-10-01 Yifan Xue , Michael Ding , Xinghua Lu

Black-box nature of Artificial Intelligence (AI) models do not allow users to comprehend and sometimes trust the output created by such model. In AI applications, where not only the results but also the decision paths to the results are…

Artificial Intelligence · Computer Science 2024-10-28 Ibrahim Kok , Feyza Yildirim Okay , Ozgecan Muyanli , Suat Ozdemir

The characterization of Tumor MicroEnvironment (TME) is challenging due to its complexity and heterogeneity. Relatively consistent TME characteristics embedded within highly specific tissue features, render them difficult to predict. The…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Fangliangzi Meng , Hongrun Zhang , Ruodan Yan , Guohui Chuai , Chao Li , Qi Liu

Developing computational tools for integrative analysis across multiple types of omics data has been of immense importance in cancer molecular biology and precision medicine research. While recent advancements have yielded integrative…

Interpretable machine learning is rapidly becoming a crucial tool for scientific discovery. Among existing approaches, variational autoencoders (VAEs) have shown promise in extracting the hidden physical features of some input data, with no…

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer

Explainable artificial intelligence (XAI) aims to develop transparent explanatory approaches for "black-box" deep learning models. However,it remains difficult for existing methods to achieve the trade-off of the three key criteria in…

Computer Vision and Pattern Recognition · Computer Science 2023-12-27 Changqi Sun , Hao Xu , Yuntian Chen , Dongxiao Zhang