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We numerically investigate how spatial variations of extensile or contractile active stress affect bulk active nematic systems in two and three dimensions. In the absence of defects, activity gradients drive flows which re-orient the…

Soft Condensed Matter · Physics 2022-06-15 Liam J Ruske , Julia M Yeomans

Active nematic models explain the topological defects and flow patterns observed in epithelial tissues, but the nature of active stress-whether it is extensile or contractile, a key parameter of the theory-is not well established…

Soft Condensed Matter · Physics 2025-11-11 Jan Rozman , Sumesh P. Thampi , Julia M. Yeomans

We study a mixture of extensile and contractile cells using a vertex model extended to include active nematic stresses. The two cell populations phase separate over time. While phase separation strengthens monotonically with an increasing…

Soft Condensed Matter · Physics 2024-10-11 Jan Rozman , Julia M. Yeomans

We model the active polar fluid as a collection of orientable objects supplied with active stresses and momentum damping coming from the viscosity of bulk fluid medium. The growth kinetics of local orientation field is studied. The effect…

Soft Condensed Matter · Physics 2023-06-13 Shambhavi Dikshit , Shradha Mishra

We numerically investigate the morphology and disclination line dynamics of active nematic droplets in three dimensions. Although our model only incorporates the simplest possible form of achiral active stress, active nematic droplets…

Soft Condensed Matter · Physics 2021-04-07 Liam J. Ruske , Julia M. Yeomans

Recent experiments in various cell types have shown that two-dimensional tissues often display local nematic order, with evidence of extensile stresses manifest in the dynamics of topological defects. Using a mesoscopic model where tissue…

Soft Condensed Matter · Physics 2021-03-30 Farzan Vafa , Mark J. Bowick , Boris I. Shraiman , M. Cristina Marchetti

Tissues of living cells are a prime example of active fluids. There is experimental evidence that tissues generate extensile active stress even though their constituting cells are contractile. Fluctuating forces that could result from…

Soft Condensed Matter · Physics 2025-07-01 Mathieu Dedenon , Karsten Kruse

We study the necking of a filament of complex fluid or soft solid subject to uniaxial tensile stretching, under conditions of constant imposed stress and force, by means of linear stability analysis and nonlinear simulations. We demonstrate…

Soft Condensed Matter · Physics 2016-11-22 David M. Hoyle , Suzanne M. Fielding

We investigate numerically, by a hybrid lattice Boltzmann method, the morphology and the dynamics of an emulsion made of a polar active gel, contractile or extensile, and an isotropic passive fluid. We focus on the case of a highly…

Soft Condensed Matter · Physics 2019-02-28 Giuseppe Negro , Livio Nicola Carenza , Pasquale Digregorio , Giuseppe Gonnella , Antonio Lamura

This study investigates the relationship between cell shape and cell-generated stresses in confluent cell layers. Using simultaneous measurements of cell shape orientation and cell-generated contractile forces in MDCK and LP-9 colonies, we…

Living cells move thanks to assemblies of actin filaments and myosin motors that range from very organized striated muscle tissue to disordered intracellular bundles. The mechanisms powering these disordered structures are debated, and all…

Biological Physics · Physics 2017-09-26 Martin Lenz

The field of active nematics has traditionally employed descriptions based on dipolar activity, with interactions that align along a single axis. However, it has been theoretically predicted that interactions with a substrate, prevalent in…

A body immersed in a nematic liquid crystal disturbs the fluid's preferred molecular configuration and increases its stored elastic energy. In an active nematic, the fluid components also generate a stress in the bulk fluid. By introducing…

Soft Condensed Matter · Physics 2025-06-17 Thomas G. J. Chandler , Saverio E. Spagnolie

We establish how active stress globally affects the morphology of disclination lines of a three dimensional active nematic liquid crystal under chaotic flow. Thanks to a defect detection algorithm based on the local nematic orientation, we…

Soft Condensed Matter · Physics 2025-06-30 Pasquale Digregorio , Cecilia Rorai , Ignacio Pagonabarraga , Federico Toschi

Point-like motile topological defects control the universal dynamics of diverse two-dimensional active nematics ranging from shaken granular rods to cellular monolayers. A comparable understanding in higher dimensions has yet to emerge. We…

How can a collection of motile cells, each generating contractile nematic stresses in isolation, become an extensile nematic at the tissue-level? Understanding this seemingly contradictory experimental observation, which occurs irrespective…

Soft Condensed Matter · Physics 2022-02-21 Andrew Killeen , Thibault Bertrand , Chiu Fan Lee

We use a computational phase-field model together with analytical analysis to study how inter-cellular active forces can mediate individual cell morphology and collective motion in a confluent cell monolayer. Contractile inter-cellular…

Soft Condensed Matter · Physics 2021-11-30 Guanming Zhang , Julia M. Yeomans

Motivated by problems arising in tear film dynamics, we present a model for the extensional flow of thin sheets of nematic liquid crystal. The rod-like molecules of these substances impart an elastic contribution to its response. We rescale…

Fluid Dynamics · Physics 2023-06-28 M. J. Taranchuk , L. J. Cummings , T. A. Driscoll , R. J. Braun

Starting from a three-dimensional description of an active nematic layer, we employ an asymptotic theory to derive a series of low-dimensional continuum models that capture the coupled dynamics of flat and curved films, including variations…

Soft Condensed Matter · Physics 2025-06-23 Mehrana R. Nejad , L. Mahadevan

While studies of active nematics in two dimensions have shed light on various aspects of the flow regimes and topology of active matter, three-dimensional properties of topological defects and chaotic flows remain unexplored. By confining a…

Soft Condensed Matter · Physics 2018-07-18 Tyler N. Shendruk , Kristian Thijssen , Julia M. Yeomans , Amin Doostmohammadi
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