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We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

Multiparametric magnetic resonance imaging (mp-MRI) has shown excellent results in the detection of prostate cancer (PCa). However, characterizing prostate lesions aggressiveness in mp-MRI sequences is impossible in clinical practice, and…

Image and Video Processing · Electrical Eng. & Systems 2022-11-28 Audrey Duran , Gaspard Dussert , Olivier Rouvière , Tristan Jaouen , Pierre-Marc Jodoin , Carole Lartizien

Despite deep convolutional neural networks boost the performance of image classification and segmentation in digital pathology analysis, they are usually weak in interpretability for clinical applications or require heavy annotations to…

Computer Vision and Pattern Recognition · Computer Science 2020-02-10 Yongxiang Huang , Albert C. S. Chung

Prostate cancer (PCa) is the most prevalent cancer among men in the United States, accounting for nearly 300,000 cases, 29\% of all diagnoses and 35,000 total deaths in 2024. Traditional screening methods such as prostate-specific antigen…

Image and Video Processing · Electrical Eng. & Systems 2025-05-27 Jarett Dewbury , Chi-en Amy Tai , Alexander Wong

Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances…

Computer Vision and Pattern Recognition · Computer Science 2018-06-08 Jian Ren , Ilker Hacihaliloglu , Eric A. Singer , David J. Foran , Xin Qi

Objective: This work addresses two key problems of skin lesion classification. The first problem is the effective use of high-resolution images with pretrained standard architectures for image classification. The second problem is the high…

Computer Vision and Pattern Recognition · Computer Science 2019-05-10 Nils Gessert , Thilo Sentker , Frederic Madesta , Rüdiger Schmitz , Helge Kniep , Ivo Baltruschat , René Werner , Alexander Schlaefer

Tissue segmentation is the mainstay of pathological examination, whereas the manual delineation is unduly burdensome. To assist this time-consuming and subjective manual step, researchers have devised methods to automatically segment…

Image and Video Processing · Electrical Eng. & Systems 2022-08-08 Yang Nan , Peng Tang , Guyue Zhang , Caihong Zeng , Zhihong Liu , Zhifan Gao , Heye Zhang , Guang Yang

Prostate cancer is one of the most common causes of cancer deaths in men. There is a growing demand for noninvasively and accurately diagnostic methods that facilitate the current standard prostate cancer risk assessment in clinical…

Image and Video Processing · Electrical Eng. & Systems 2021-12-30 Ping-Chang Lin , Teodora Szasz , Hakizumwami B. Runesha

Determining early-stage prognostic markers and stratifying patients for effective treatment are two key challenges for improving outcomes for melanoma patients. Previous studies have used tumour transcriptome data to stratify patients into…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Lucy Godson , Navid Alemi , Jeremie Nsengimana , Graham P. Cook , Emily L. Clarke , Darren Treanor , D. Timothy Bishop , Julia Newton-Bishop , Ali Gooya

The current study detects different morphologies related to prostate pathology using deep learning models; these models were evaluated on 2,121 hematoxylin and eosin (H&E) stain histology images captured using bright field microscopy, which…

Ovarian cancer remains a challenging malignancy to diagnose and manage, with prognosis heavily dependent on the stage at detection. Accurate grading and staging, primarily based on histopathological examination of biopsy tissue samples, are…

Medical Physics · Physics 2025-05-16 Ashmit K Mishra , Mousa Alrubayan , Prabhakar Pradhan

Multiple Instance Learning (MIL) has been widely applied in histopathology to classify Whole Slide Images (WSIs) with slide-level diagnoses. While the ground truth is established by expert pathologists, the slides can be difficult to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Marie Arrivat , Rémy Peyret , Elsa Angelini , Pietro Gori

Skin cancer, the most common human malignancy, is primarily diagnosed visually by physicians [1]. Classification with an automated method like CNN [2, 3] shows potential for challenging tasks [1]. By now, the deep convolutional neural…

Computer Vision and Pattern Recognition · Computer Science 2017-03-13 Wenhao Zhang , Liangcai Gao , Runtao Liu

We investigate the potential of self-supervision in improving the accuracy of deep learning models trained to classify melanoma patches. Various self-supervision techniques such as rotation prediction, missing patch prediction, and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Srivishnu Vusirikala , Suraj Rajendran

Histopathological images provide rich information for disease diagnosis. Large numbers of histopathological images have been digitized into high resolution whole slide images, opening opportunities in developing computational image analysis…

Image and Video Processing · Electrical Eng. & Systems 2020-11-06 Jiayun Li , Wenyuan Li , Anthony Sisk , Huihui Ye , W. Dean Wallace , William Speier , Corey W. Arnold

Gleason grading of prostate cancer is an important prognostic factor but suffers from poor reproducibility, particularly among non-subspecialist pathologists. Although artificial intelligence (A.I.) tools have demonstrated Gleason grading…

Prostate and zonal segmentation is a crucial step for clinical diagnosis of prostate cancer (PCa). Computer-aided diagnosis tools for prostate segmentation are based on the deep learning (DL) paradigm. However, deep neural networks are…

While data-driven approaches excel at many image analysis tasks, the performance of these approaches is often limited by a shortage of annotated data available for training. Recent work in semi-supervised learning has shown that meaningful…

Computer Vision and Pattern Recognition · Computer Science 2021-01-22 Mayank Golhar , Taylor L. Bobrow , MirMilad Pourmousavi Khoshknab , Simran Jit , Saowanee Ngamruengphong , Nicholas J. Durr

Prostate cancer (PCa) is graded by pathologists by examining the architectural pattern of cancerous epithelial tissue on hematoxylin and eosin (H&E) stained slides. Given the importance of gland morphology, automatically differentiating…

Data-driven methods have shown tremendous progress in medical image analysis. In this context, deep learning-based supervised methods are widely popular. However, they require a large amount of training data and face issues in…

Computer Vision and Pattern Recognition · Computer Science 2023-06-02 Ziang Xu , Jens Rittscher , Sharib Ali