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Big imaging data is becoming more prominent in brain sciences across spatiotemporal scales and phylogenies. We have developed a computational ecosystem that enables storage, visualization, and analysis of these data in the cloud, thusfar…

Accurate segmentation of brain tissues such as gray matter and white matter from magnetic resonance imaging is essential for studying brain anatomy, diagnosing neurological disorders, and monitoring disease progression. Traditional methods,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Chang Sun , Rui Shi , Tsukasa Koike , Tetsuro Sekine , Akio Morita , Tetsuya Sakai

Recent advances in neuroimaging have deepened our understanding of the brain's complex functional and structural organization. Among these, functional Magnetic Resonance Imaging (fMRI) - particularly resting-state fMRI (rs-fMRI) - has…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 M. Moein Esfahani , Sepehr Salem Ghahfarokhi , Mohammed Alser , Jingyu Liu , Vince Calhoun

The exponential growth of neuroscience literature presents a significant challenge for researchers seeking to efficiently access and utilize relevant information. To address this issue, we introduce the Brain Knowledge Engine (BrainKnow),…

Digital Libraries · Computer Science 2024-06-07 Cunqing Huangfu , Kang Sun , Yi Zeng , Yuwei Wang , Dongsheng Wang , Zizhe Ruan

With the wide adoption of functional magnetic resonance imaging (fMRI) by cognitive neuroscience researchers, large volumes of brain imaging data have been accumulated in recent years. Aggregating these data to derive scientific insights…

Applications · Statistics 2020-06-01 Ming Bo Cai , Michael Shvartsman , Anqi Wu , Hejia Zhang , Xia Zhu

Deep learning models usually require sufficient training data to achieve high accuracy, but obtaining labeled data can be time-consuming and labor-intensive. Here we introduce a template-based training method to train a 3D U-Net model from…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Fang-Cheng Yeh

The release of large datasets and developments in AI have led to dramatic improvements in decoding methods that reconstruct seen images from human brain activity. We evaluate the prospect of further improving recent decoding methods by…

Neurons and Cognition · Quantitative Biology 2023-12-14 Reese Kneeland , Jordyn Ojeda , Ghislain St-Yves , Thomas Naselaris

3D image segmentation is one of the most important and ubiquitous problems in medical image processing. It provides detailed quantitative analysis for accurate disease diagnosis, abnormal detection, and classification. Currently deep…

Computer Vision and Pattern Recognition · Computer Science 2019-06-19 Zhenxi Zhang , Jie Li , Zhusi Zhong , Zhicheng Jiao , Xinbo Gao

Skull stripping is usually the first step for most brain analysisprocess in magnetic resonance images. A lot of deep learn-ing neural network based methods have been developed toachieve higher accuracy. Since the 3D deep learning…

Image and Video Processing · Electrical Eng. & Systems 2019-10-25 Zhen Liu , Borui Xiao , Yuemeng Li , Yong Fan

Magnetic resonance imaging (MRI) is critically important for brain mapping in both scientific research and clinical studies. Precise segmentation of brain tumors facilitates clinical diagnosis, evaluations, and surgical planning. Deep…

Image and Video Processing · Electrical Eng. & Systems 2023-05-01 Rui Nian , Guoyao Zhang , Yao Sui , Yuqi Qian , Qiuying Li , Mingzhang Zhao , Jianhui Li , Ali Gholipour , Simon K. Warfield

Skull-stripping is the removal of background and non-brain anatomical features from brain images. While many skull-stripping tools exist, few target pediatric populations. With the emergence of multi-institutional pediatric data acquisition…

Image and Video Processing · Electrical Eng. & Systems 2025-12-05 William Kelley , Nathan Ngo , Adrian V. Dalca , Bruce Fischl , Lilla Zöllei , Malte Hoffmann

We propose a dual pathway, 11-layers deep, three-dimensional Convolutional Neural Network for the challenging task of brain lesion segmentation. The devised architecture is the result of an in-depth analysis of the limitations of current…

Computer Vision and Pattern Recognition · Computer Science 2017-01-10 Konstantinos Kamnitsas , Christian Ledig , Virginia F. J. Newcombe , Joanna P. Simpson , Andrew D. Kane , David K. Menon , Daniel Rueckert , Ben Glocker

Combining Functional MRI (fMRI) data across different subjects and datasets is crucial for many neuroscience tasks. Relying solely on shared anatomy for brain-to-brain mapping is inadequate. Existing functional transformation methods thus…

Neurons and Cognition · Quantitative Biology 2025-03-18 Navve Wasserman , Roman Beliy , Roy Urbach , Michal Irani

There are multiple scales of abstraction from which we can describe the same image, depending on whether we are focusing on fine-grained details or a more global attribute of the image. In brain mapping, learning to automatically parse…

Clinical deployment of automated brain MRI analysis faces a fundamental challenge: clinical data is heterogeneous and noisy, and high-quality labels are prohibitively costly to obtain. Self-supervised learning (SSL) can address this by…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Asbjørn Munk , Stefano Cerri , Vardan Nersesjan , Christian Hedeager Krag , Jakob Ambsdorf , Pablo Rocamora García , Julia Machnio , Peirong Liu , Suhyun Ahn , Nasrin Akbari , Yasmina Al Khalil , Kimberly Amador , Sina Amirrajab , Tal Arbel , Meritxell Bach Cuadra , Ujjwal Baid , Bhakti Baheti , Jaume Banus , Kamil Barbierik , Christoph Brune , Yansong Bu , Baptiste Callard , Yuhan Chen , Cornelius Crijnen , Corentin Dancette , Peter Drotar , Prasad Dutande , Nils D. Forkert , Saurabh Garg , Jakub Gazda , Matej Gazda , Benoît Gérin , Partha Ghosh , Weikang Gong , Pedro M. Gordaliza , Sam Hashemi , Tobias Heimann , Fucang Jia , Jiexin Jiang , Emily Kaczmarek , Chris Kang , Seung Kwan Kang , Mohammad Khazaei , Julien Khlaut , Petros Koutsouvelis , Jae Sung Lee , Yuchong Li , Mengye Lyu , Mingchen Ma , Anant Madabhushi , Klaus H. Maier-Hein , Pierre Manceron , Andrés Martínez Mora , Moona Mazher , Felix Meister , Nataliia Molchanova , Steven A. Niederer , Leonard Nürnberg , Jinah Park , Abdul Qayyum , Jonas Richiardi , Antoine Saporta , Branislav Setlak , Ning Shen , Justin Szeto , Constantin Ulrich , Puru Vaish , Vibujithan Vigneshwaran , Leroy Volmer , Zihao Wang , Siqi Wei , Anthony Winder , Jelmer M. Wolterink , Maxence Wynen , Chang Yang , Si Young Yie , Mostafa Mehdipour Ghazi , Akshay Pai , Espen Jimenez Solem , Sebastian Nørgaard Llambias , Mikael Boesen , Michael Eriksen Benros , Juan Eugenio Iglesias , Mads Nielsen

In this study, we proposed and validated a multi-atlas guided 3D fully convolutional network (FCN) ensemble model (M-FCN) for segmenting brain regions of interest (ROIs) from structural magnetic resonance images (MRIs). One major limitation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-11 Jiong Wu , Xiaoying Tang

Deep learning models generating structural brain MRIs have the potential to significantly accelerate discovery of neuroscience studies. However, their use has been limited in part by the way their quality is evaluated. Most evaluations of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-16 Jiaqi Wu , Wei Peng , Binxu Li , Yu Zhang , Kilian M. Pohl

Surface analysis of the cortex is ubiquitous in human neuroimaging with MRI, e.g., for cortical registration, parcellation, or thickness estimation. The convoluted cortical geometry requires isotropic scans (e.g., 1mm MPRAGEs) and good…

Image and Video Processing · Electrical Eng. & Systems 2023-05-04 Karthik Gopinath , Douglas N. Greve , Sudeshna Das , Steve Arnold , Colin Magdamo , Juan Eugenio Iglesias

Deep learning models have revolutionized the field of medical image analysis, offering significant promise for improved diagnostics and patient care. However, their performance can be misleadingly optimistic due to a hidden pitfall called…

Image and Video Processing · Electrical Eng. & Systems 2025-05-12 Dewinda Julianensi Rumala

Functional brain network analysis has become an indispensable tool for brain disease analysis. It is profoundly impacted by deep learning methods, which can characterize complex connections between ROIs. However, the research on foundation…

Image and Video Processing · Electrical Eng. & Systems 2025-08-08 Yifei Tang , Hongjie Jiang , Changhong Jing , Hieu Pham , Shuqiang Wang