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We study DNA self-assembly and DNA computation using a coarse-grained DNA model within the directional dynamic bonding framework {[}C. Svaneborg, Comp. Phys. Comm. 183, 1793 (2012){]}. In our model, a single nucleotide or domain is…

Soft Condensed Matter · Physics 2012-06-13 Carsten Svaneborg , Harold Fellermann , Steen Rasmussen

The oxDNA model of DNA has been applied widely to systems in biology, biophysics and nanotechnology. It is currently available via two independent open source packages. Here we present a set of clearly-documented exemplar simulations that…

Biomolecules · Quantitative Biology 2022-09-26 Aditya Sengar , Thomas E. Ouldridge , Oliver Henrich , Lorenzo Rovigatti , Petr Sulc

DNA data storage offers a high-density, long-term alternative to traditional storage systems, addressing the exponential growth of digital data. Composite DNA extends this paradigm by leveraging mixtures of nucleotides to increase storage…

Information Theory · Computer Science 2026-02-13 Busra Tegin , Tolga M Duman

A theoretical memory with limited processing power and internal connectivity at each element is proposed. This memory carries out parallel processing within itself to solve generic array problems. The applicability of this in-memory…

Distributed, Parallel, and Cluster Computing · Computer Science 2010-09-28 Chengpu Wang

The string splicing was introduced by Tom Head which stands as an abstract model for the DNA recombination under the influence of restriction enzymes. The complex chemical process of three dimensional molecules in three dimensional space…

Discrete Mathematics · Computer Science 2007-05-23 L. Jeganathan , R. Rama

Modular trapped-ion (TI) architectures offer a scalable quantum computing (QC) platform, with native transport behaviors that closely resemble the Single Instruction Multiple Data (SIMD) paradigm. We present FluxTrap, a SIMD-aware compiler…

DNA origami consists of a long scaffold strand and short staple strands that self-assemble into a target 2D or 3D shape. It is a widely used construct in nucleic acid nanotechnology, offering a cost-effective way to design and create…

Soft Condensed Matter · Physics 2024-09-23 Sarah Haggenmueller , Michael Matthies , Matthew Sample , Petr Šulc

2D display is a fast and economical way of visualizing polymorphism and comparing genomes, which is based on the separation of DNA fragments in two steps, according first to their size and then to their sequence composition. In this paper,…

Biomolecules · Quantitative Biology 2009-10-29 Ana-Maria Florescu , Marc Joyeux , Benedicte Lafay

Domain decomposition is a technique used to reduce memory overhead on large neutron transport problems. Currently, the optimal load-balanced processor allocation for these domains is typically determined through small-scale simulations of…

Computational Physics · Physics 2025-08-18 Alexander Mote , Todd Palmer , Lizhong Chen

With conventional silicon-based computing approaching its physical and efficiency limits, biocomputing emerges as a promising alternative. This approach utilises biomaterials such as DNA and neurons as an interesting alternative to data…

Emerging Technologies · Computer Science 2024-08-15 Giulio Basso , Reinhold Scherer , Michael Taynnan Barros

The brain is dynamic, associative and efficient. It reconfigures by associating the inputs with past experiences, with fused memory and processing. In contrast, AI models are static, unable to associate inputs with past experiences, and run…

Because of DNA appealing features as perfect material, including minuscule size, defined structural repeat and rigidity, programmable DNA-mediated processing is a promising computing paradigm, which employs DNAs as information storing and…

Biological Physics · Physics 2015-08-17 Jian-Jun Shu , Qi-Wen Wang , Kian-Yan Yong , Fangwei Shao , Kee Jin Lee

Geometrical Computation as a new model of computation is the counterpart of Cellular Automata that has Turing computing ability. In this paper we provide an algorithm to simulate Alternating Turing Machine in the context of Signal Machine…

Computational Geometry · Computer Science 2017-09-01 Dawood Hasanzadeh , Sama Goliaei

Due to its longevity and enormous information density, DNA is an attractive medium for archival storage. In this work, we study the fundamental limits and trade-offs of DNA-based storage systems by introducing a new channel model, which we…

Information Theory · Computer Science 2020-01-20 Ilan Shomorony , Reinhard Heckel

We describe a modified SIMD architecture suitable for single-chip integration of a large number of processing elements, such as 1,000 or more. Important differences from traditional SIMD designs are: a) The size of the memory per processing…

Astrophysics · Physics 2007-05-23 Junichiro Makino

Stochastic simulation can make the molecular processes of cellular control more vivid than the traditional differential-equation approach by generating typical system histories instead of just statistical measures such as the mean and…

Subcellular Processes · Quantitative Biology 2018-09-18 Kevin Y. Chen , Daniel M. Zuckerman , Philip C. Nelson

This paper discusses how to implement certain classes of quantum computer algorithms using classical discrete switching networks that are amenable to implementation in main stream CMOS transistor IC technology. The methods differ from other…

Computational Complexity · Computer Science 2009-05-14 John S. Hamel

Processing-in-memory (PIM) has shown extraordinary potential in accelerating neural networks. To evaluate the performance of PIM accelerators, we present an ISA-based simulation framework including a dedicated ISA targeting neural networks…

Hardware Architecture · Computer Science 2024-02-29 Xinyu Wang , Xiaotian Sun , Yinhe Han , Xiaoming Chen

DNA has been discussed as a potential medium for data storage. Potentially it could be denser, could consume less energy, and could be more durable than conventional storage media such as hard drives, solid-state storage, and optical media.…

Emerging Technologies · Computer Science 2023-07-04 Arnav Solanki , Zak Griffin , Purab Ranjan Sutradhar , Amlan Ganguly , Marc D. Riedel

The goal of neuro-symbolic AI is to integrate symbolic and subsymbolic AI approaches, to overcome the limitations of either. Prominent systems include Logic Tensor Networks (LTN) or DeepProbLog, which offer neural predicates and end-to-end…

Artificial Intelligence · Computer Science 2025-06-18 Stephen Roth , Lennart Baur , Derian Boer , Stefan Kramer