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The errors occurring in DNA-based storage are correlated in nature, which is a direct consequence of the synthesis and sequencing processes. In this paper, we consider the memory-$k$ nanopore channel model recently introduced by Hamoum et…

Information Theory · Computer Science 2023-03-27 Issam Maarouf , Eirik Rosnes , Alexandre Graell i Amat

Double-stranded DNA translocates through sufficiently large nanopores either in a linear, single-file fashion or in a folded hairpin conformation when captured somewhere along its length. We show that the folding state of DNA can be…

Biological Physics · Physics 2018-08-15 Niklas Ermann , Nikita Hanikel , Vivian Wang , Kaikai Chen , Ulrich F. Keyser

In the framework of convolutional neural networks that lie at the heart of deep learning, downsampling is often performed with a max-pooling operation that only retains the element with maximum activation, while completely discarding the…

Computer Vision and Pattern Recognition · Computer Science 2018-04-17 Ashwani Kumar

Nanopore sensing is a key technology for single-molecule detection and analysis. Solid-state nanopores have emerged as a versatile platform, since their fabrication allows to engineer their properties by controlling size, shape, and…

Recent years have seen a surge of interest in nanopores because such structures show a strong potential for characterizing nanoparticles, proteins, DNA, and even single molecules. These systems have been extensively studied in experiment as…

Soft Condensed Matter · Physics 2016-06-22 Georg Rempfer , Sascha Ehrhardt , Christian Holm , Joost de Graaf

Solid-state nanopores are emerging platforms for single-molecule protein sequencing due to their tolerance to hash physiology environment and compatibility with different electrical and optical detection methods. However, they suffer from…

Applied Physics · Physics 2024-01-05 Yingqi Zhao , Aliaksandr Hubarevich , Jian-An Huang , Francesco De Angelis

Featured by centralized processing and cloud based infrastructure, Cloud Radio Access Network (C-RAN) is a promising solution to achieve an unprecedented system capacity in future wireless cellular networks. The huge capacity gain mainly…

Information Theory · Computer Science 2014-12-30 Congmin Fan , Ying Jun Zhang , Xiaojun Yuan

Using molecular dynamics simulations, we show that, when subject to a periodic external electric field, a nanopore in ionic solution acts as a capacitor with memory (memcapacitor) at various frequencies and strengths of the electric field.…

Soft Condensed Matter · Physics 2010-07-20 Matt Krems , Yuriy V. Pershin , Massimiliano Di Ventra

The two strands of a DNA molecule with a repetitive sequence can pair into many different basepairing patterns. For perfectly periodic sequences, early bulk experiments of Poerschke indicate the existence of a sliding process, permitting…

Biomolecules · Quantitative Biology 2007-05-23 Richard A. Neher , Ulrich Gerland

We propose a novel molecular computing approach based on reservoir computing. In reservoir computing, a dynamical core, called a reservoir, is perturbed with an external input signal while a readout layer maps the reservoir dynamics to a…

Neural and Evolutionary Computing · Computer Science 2019-11-12 Alireza Goudarzi , Matthew R. Lakin , Darko Stefanovic

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of…

Soft Condensed Matter · Physics 2015-06-25 Johan Lagerqvist , Michael Zwolak , Massimiliano Di Ventra

Extracting the sequence information of DNA from the blocked ionic current is the crucial step of the ionic current-based nanopore sequencing approaches. The thinnest graphene nanopore, which contained only one layer of carbon atoms,…

Biological Physics · Physics 2014-01-29 Wenping Lv , Ren'an Wu

The size and shape of the receptive field determine how the network aggregates local information and affect the overall performance of a model considerably. Many components in a neural network, such as kernel sizes and strides for…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Dong-Hwan Jang , Sanghyeok Chu , Joonhyuk Kim , Bohyung Han

Time Delay Neural Networks (TDNN)-based methods are widely used in dialect identification. However, in previous work with TDNN application, subtle variant is being neglected in different feature scales. To address this issue, we propose a…

Computation and Language · Computer Science 2021-08-18 Tianlong Kong , Shouyi Yin , Dawei Zhang , Wang Geng , Xin Wang , Dandan Song , Jinwen Huang , Huiyu Shi , Xiaorui Wang

Transformers achieve unrivalled performance in modelling language, but remain inefficient in terms of memory and time complexity. A possible remedy is to reduce the sequence length in the intermediate layers by pooling fixed-length segments…

Computation and Language · Computer Science 2023-10-25 Piotr Nawrot , Jan Chorowski , Adrian Łańcucki , Edoardo M. Ponti

A device capable of performing real time classification of proteins in a clinical setting would allow for inexpensive and rapid disease diagnosis. One such candidate for this technology are nanopore devices. These devices work by measuring…

Machine Learning · Computer Science 2025-09-18 Samuel Tovey , Julian Hoßbach , Sandro Kuppel , Tobias Ensslen , Jan C. Behrends , Christian Holm

Raw nanopore signal analysis is a common approach in genomics to provide fast and resource-efficient analysis without translating the signals to bases (i.e., without basecalling). However, existing solutions cannot interpret raw signals…

We present in this paper a simple, yet efficient convolutional neural network (CNN) architecture for robust audio event recognition. Opposing to deep CNN architectures with multiple convolutional and pooling layers topped up with multiple…

Neural and Evolutionary Computing · Computer Science 2016-06-23 Huy Phan , Lars Hertel , Marco Maass , Alfred Mertins

We propose two-terminal devices for DNA sequencing which consist of a metallic graphene nanoribbon with zigzag edges (ZGNR) and a nanopore in its interior through which the DNA molecule is translocated. Using the nonequilibrium Green…

Mesoscale and Nanoscale Physics · Physics 2012-01-26 Kamal K. Saha , Marija Drndic , Branislav K. Nikolic

Monaural Singing Voice Separation (MSVS) is a challenging task and has been studied for decades. Deep neural networks (DNNs) are the current state-of-the-art methods for MSVS. However, the existing DNNs are often designed manually, which is…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-04 Weitao Yuan , Bofei Dong , Shengbei Wang , Masashi Unoki , Wenwu Wang
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