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With the prevailing efforts to combat the coronavirus disease 2019 (COVID-19) pandemic, there are still uncertainties that are yet to be discovered about its spread, future impact, and resurgence. In this paper, we present a three-stage…

Machine Learning · Statistics 2024-06-19 Oluwaseun T. Ajayi , Yu Cheng

Most existing causal structure learning methods assume data collected from one environment and independent and identically distributed (i.i.d.). In some cases, data are collected from different subjects from multiple environments, which…

Machine Learning · Computer Science 2023-02-07 Wei Chen , Yunjin Wu , Ruichu Cai , Yueguo Chen , Zhifeng Hao

Causal structure learning (CSL), a prominent technique for encoding cause-and-effect relationships among variables, through Bayesian Networks (BNs). Although recovering causal structure solely from data is a challenge, the integration of…

Machine Learning · Computer Science 2025-10-22 Lyuzhou Chen , Taiyu Ban , Xiangyu Wang , Derui Lyu , Huanhuan Chen

Understanding the factors that trigger or prevent undesirable health outcomes across patient subpopulations is essential for designing targeted interventions. While randomized controlled trials and expert-led patient interviews are standard…

Artificial Intelligence · Computer Science 2026-05-28 Shishir Adhikari , Guido Muscioni , Mark Shapiro , Plamen Petrov , Elena Zheleva

Learning-based signal processing systems increasingly support high-stakes medical decisions using heterogeneous biomedical signals, including medical images, physiological time series, and clinical records. Despite strong predictive…

Signal Processing · Electrical Eng. & Systems 2026-03-02 Surajit Das , Maxine Tan

Long-running clinical trials offer a unique opportunity to study disease progression and treatment response over time, enabling questions about how and when interventions alter patient trajectories. However, drawing causal conclusions in…

Applications · Statistics 2025-08-13 Emma Prevot , Dieter A. Häring , Thomas E. Nichols , Chris C. Holmes , Habib Ganjgahi

Introduction: For COVID-19 patients accurate prediction of disease severity and mortality risk would greatly improve care delivery and resource allocation. There are many patient-related factors, such as pre-existing comorbidities that…

Current clinical decision support systems (CDSSs) typically base their predictions on correlation, not causation. In recent years, causal machine learning (ML) has emerged as a promising way to improve decision-making with CDSSs by offering…

Human-Computer Interaction · Computer Science 2026-04-17 Domenique Zipperling , Lukas Schmidt , Benedikt Hahn , Niklas Kühl , Steven Kimbrough

Causal discovery from observational data is pivotal for deciphering complex relationships. Causal Structure Learning (CSL), which focuses on deriving causal Directed Acyclic Graphs (DAGs) from data, faces challenges due to vast DAG spaces…

Artificial Intelligence · Computer Science 2023-11-21 Taiyu Ban , Lyuzhou Chen , Derui Lyu , Xiangyu Wang , Huanhuan Chen

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable…

Machine Learning · Computer Science 2023-01-20 Pulakesh Upadhyaya , Kai Zhang , Can Li , Xiaoqian Jiang , Yejin Kim

Learning causal relationships between variables is a well-studied problem in statistics, with many important applications in science. However, modeling real-world systems remain challenging, as most existing algorithms assume that the…

Causal machine learning (ML) algorithms recover graphical structures that tell us something about cause-and-effect relationships. The causal representation praovided by these algorithms enables transparency and explainability, which is…

As the COVID-19 pandemic continues to devastate globally, one promising field of research is machine learning-driven computer vision to streamline various parts of the COVID-19 clinical workflow. These machine learning methods are typically…

Image and Video Processing · Electrical Eng. & Systems 2021-09-15 Audrey G. Chung , Maya Pavlova , Hayden Gunraj , Naomi Terhljan , Alexander MacLean , Hossein Aboutalebi , Siddharth Surana , Andy Zhao , Saad Abbasi , Alexander Wong

The importance of clinical variables in the prognosis of the disease is explained using statistical correlation or machine learning (ML). However, the predictive importance of these variables may not represent their causal relationships…

Machine Learning · Statistics 2025-06-04 Yina Hou , Shourav B. Rabbani , Liang Hong , Norou Diawara , Manar D. Samad

Causal Structure Learning (CSL), also referred to as causal discovery, amounts to extracting causal relations among variables in data. CSL enables the estimation of causal effects from observational data alone, avoiding the need to perform…

Machine Learning · Computer Science 2025-02-12 Fabrizio Russo , Francesca Toni

Learning the causal structure behind data is invaluable for improving generalization and obtaining high-quality explanations. We propose a novel framework, Invariant Structure Learning (ISL), that is designed to improve causal structure…

Machine Learning · Computer Science 2022-06-15 Yunhao Ge , Sercan Ö. Arik , Jinsung Yoon , Ao Xu , Laurent Itti , Tomas Pfister

Severe acute respiratory disease SARS-CoV-2 has had a found impact on public health systems and healthcare emergency response especially with respect to making decisions on the most effective measures to be taken at any given time. As…

Machine Learning · Computer Science 2023-09-19 Charithea Stylianides , Kleanthis Malialis , Panayiotis Kolios

Large-scale longitudinal molecular profiling is now firmly established in biomedical research, prompted by the need to uncover coordinated biomarker trajectories reflecting the dynamics of underlying biological mechanisms and characterise…

Methodology · Statistics 2026-03-24 Salima Jaoua , Daniel Temko , Hélène Ruffieux

Estimating personalized treatment effects from high-dimensional observational data is essential in situations where experimental designs are infeasible, unethical, or expensive. Existing approaches rely on fitting deep models on outcomes…

Machine Learning · Computer Science 2022-02-02 Andrew Jesson , Panagiotis Tigas , Joost van Amersfoort , Andreas Kirsch , Uri Shalit , Yarin Gal

Causal learning has long concerned itself with the accurate recovery of underlying causal mechanisms. Such causal modelling enables better explanations of out-of-distribution data. Prior works on causal learning assume that the high-level…

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