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Coronary angiography is considered to be a safe tool for the evaluation of coronary artery disease and perform in approximately 12 million patients each year worldwide. [1] In most cases, angiograms are manually analyzed by a cardiologist.…

Computer Vision and Pattern Recognition · Computer Science 2017-06-07 Stanislav Filippov , Arsenii Moiseev , Andronenko Andrey

Reconstructing the intricate local morphology of neurons and their long-range projecting axons can address many connectivity related questions in neuroscience. The main bottleneck in connectomics pipelines is correcting topological errors,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Anna Grim , Jayaram Chandrashekar , Uygar Sumbul

Neurons, with their elongated, tree-like dendritic and axonal structures, enable efficient signal integration and long-range communication across brain regions. By reconstructing individual neurons' morphology, we can gain valuable insights…

Computer Vision and Pattern Recognition · Computer Science 2024-11-08 Rubin Zhao , Yang Liu , Shiqi Zhang , Zijian Yi , Yanyang Xiao , Fang Xu , Yi Yang , Pencheng Zhou

Promoting the connectivity of curvilinear structures, such as neuronal processes in biomedical scans and blood vessels in CT images, remains a key challenge in semantic segmentation. Traditional pixel-wise loss functions, including…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Elyar Esmaeilzadeh , Ehsan Garaaghaji , Farzad Hallaji Azad , Doruk Oner

The throughput of electron microscopes has increased significantly in recent years, enabling detailed analysis of cell morphology and ultrastructure. Analysis of neural circuits at single-synapse resolution remains the flagship target of…

Computer Vision and Pattern Recognition · Computer Science 2019-08-07 Constantin Pape , Alex Matskevych , Adrian Wolny , Julian Hennies , Giula Mizzon , Marion Louveaux , Jacob Musser , Alexis Maizel , Detlev Arendt , Anna Kreshuk

One of the central problems in neuroscience is reconstructing synaptic connectivity in neural circuits. Synapses onto a neuron can be probed by sequentially stimulating potentially pre-synaptic neurons while monitoring the membrane voltage…

Neurons and Cognition · Quantitative Biology 2012-10-05 Tao Hu , Dmitri B. Chklovskii

In the field of Connectomics, a primary problem is that of 3D neuron segmentation. Although deep learning-based methods have achieved remarkable accuracy, errors still exist, especially in regions with image defects. One common type of…

Computer Vision and Pattern Recognition · Computer Science 2021-12-14 Jules Berman , Dmitri B. Chklovskii , Jingpeng Wu

We show dense voxel embeddings learned via deep metric learning can be employed to produce a highly accurate segmentation of neurons from 3D electron microscopy images. A "metric graph" on a set of edges between voxels is constructed from…

Computer Vision and Pattern Recognition · Computer Science 2021-08-09 Kisuk Lee , Ran Lu , Kyle Luther , H. Sebastian Seung

Trustworthiness in neural networks is crucial for their deployment in critical applications, where reliability, confidence, and uncertainty play pivotal roles in decision-making. Traditional performance metrics such as accuracy and…

Machine Learning · Computer Science 2025-09-05 Koffi Ismael Ouattara , Ioannis Krontiris , Theo Dimitrakos , Frank Kargl

Inferring a binary connectivity graph from resting-state fMRI data for a single subject requires making several methodological choices and assumptions that can significantly affect the results. In this study, we investigate the robustness…

Methodology · Statistics 2025-03-20 Alice Chevaux , Ali Fahkar , Kévin Polisano , Irène Gannaz , Sophie Achard

Due to the complicated nanoscale structures of current integrated circuits(IC) builds and low error tolerance of IC image segmentation tasks, most existing automated IC image segmentation approaches require human experts for visual…

Computer Vision and Pattern Recognition · Computer Science 2022-11-09 Zhikang Zhang , Bruno Machado Trindade , Michael Green , Zifan Yu , Christopher Pawlowicz , Fengbo Ren

Comprehensive, synapse-resolution imaging of the brain will be crucial for understanding neuronal computations and function. In connectomics, this has been the sole purview of volume electron microscopy (EM), which entails an excruciatingly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Yicong Li , Yaron Meirovitch , Aaron T. Kuan , Jasper S. Phelps , Alexandra Pacureanu , Wei-Chung Allen Lee , Nir Shavit , Lu Mi

Segmentation of microscopy images constitutes an ill-posed inverse problem due to measurement noise, weak object boundaries, and limited labeled data. Although deep neural networks provide flexible nonparametric estimators, unconstrained…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Seema K. Poudel , Sunny K. Khadka

Blood vessel segmentation and -tracing are essential tasks in many medical imaging applications. Although numerous methods exist, the prevailing segment-then-fix paradigm is fundamentally limited regarding its suitability for modeling the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-04 Rajalakshmi Palaniappan , Christoph Karg , Nemesio Navarro-Arambula , Peter Hirsch , Kristin Kraeker , Lisa Mais , Dagmar Kainmueller

We present a data-driven framework to automate the vectorization and machine interpretation of 2D engineering part drawings. In industrial settings, most manufacturing engineers still rely on manual reads to identify the topological and…

Computer Vision and Pattern Recognition · Computer Science 2023-03-15 Wentai Zhang , Joe Joseph , Yue Yin , Liuyue Xie , Tomotake Furuhata , Soji Yamakawa , Kenji Shimada , Levent Burak Kara

In this work, we propose a single deep neural network for panoptic segmentation, for which the goal is to provide each individual pixel of an input image with a class label, as in semantic segmentation, as well as a unique identifier for…

Computer Vision and Pattern Recognition · Computer Science 2019-02-08 Daan de Geus , Panagiotis Meletis , Gijs Dubbelman

Recent advancements in vision models have greatly improved their ability to handle complex chart understanding tasks, like chart captioning and question answering. However, it remains challenging to assess how these models process charts.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Soohyun Lee , Minsuk Chang , Seokhyeon Park , Jinwook Seo

Constructing latent vector representation for nodes in a network through embedding models has shown its practicality in many graph analysis applications, such as node classification, clustering, and link prediction. However, despite the…

Human-Computer Interaction · Computer Science 2018-08-29 Quan Li , Kristanto Sean Njotoprawiro , Hammad Haleem , Qiaoan Chen , Chris Yi , Xiaojuan Ma

Despite substantial progress in applying neural networks (NN) to a wide variety of areas, they still largely suffer from a lack of transparency and interpretability. While recent developments in explainable artificial intelligence attempt…

Computer Vision and Pattern Recognition · Computer Science 2021-05-04 Yunhao Ge , Yao Xiao , Zhi Xu , Meng Zheng , Srikrishna Karanam , Terrence Chen , Laurent Itti , Ziyan Wu

A central problem in neuroscience is reconstructing neuronal circuits on the synapse level. Due to a wide range of scales in brain architecture such reconstruction requires imaging that is both high-resolution and high-throughput. Existing…

Computer Vision and Pattern Recognition · Computer Science 2012-10-03 Tao Hu , Juan Nunez-Iglesias , Shiv Vitaladevuni , Lou Scheffer , Shan Xu , Mehdi Bolorizadeh , Harald Hess , Richard Fetter , Dmitri Chklovskii